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Saccharin: a green, economical and efficient catalyst for the one-pot, multi-component synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole

Journal of the Iranian Chemical Society volume 13, pages 1549–1560 (2016)Cite this article

Abstract

In this method, we have reported the catalytic ability of saccharin as a green, eco-friendly catalyst for the multi-component efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and 1H-pyrazolo [1,2-b]phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole with excellent yields and short reaction times. This present methodology has notable benefits such as green, inexpensive and non-toxic catalyst, one-pot, environmental benign nature, solvent-free conditions, simplicity of operation with no necessity of chromatographic purification steps and eco-friendly.

Graphical Abstract

We have studied the catalytic ability of saccharin as a green, economical and environmentally benign nature for the multi-component efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-ones derivatives, 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole with excellent yields and short reaction times. Green catalyst, mild, non-toxic, inexpensive, simple operational procedures, one-pot, high catalytic activity, eco-friendly, easily separated from the reaction mixture with no column chromatographic for the one-pot multi-component synthesis of these compounds are the most important advantages of this procedure.

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Acknowledgments

We gratefully acknowledge financial support from the research council of the university of Sistan and Baluchestan.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran

    Farzaneh Mohamadpour, Malek Taher Maghsoodlou & Reza Heydari

  2. Faculty of Science, Velayat University, Iranshahr, Iran

    Mojtaba Lashkari

Authors
  1. Farzaneh Mohamadpour
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  2. Malek Taher Maghsoodlou
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  3. Reza Heydari
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  4. Mojtaba Lashkari
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Correspondence to Malek Taher Maghsoodlou.

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Mohamadpour, F., Maghsoodlou, M.T., Heydari, R. et al. Saccharin: a green, economical and efficient catalyst for the one-pot, multi-component synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole. J IRAN CHEM SOC 13, 1549–1560 (2016). https://doi.org/10.1007/s13738-016-0871-5

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  • DOI: https://doi.org/10.1007/s13738-016-0871-5

Keywords

  • Green synthesis
  • Saccharin
  • Eco-friendly
  • 3,4-Dihydropyrimidinone
  • 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives
  • Dihydro-2-oxypyrrole substituted
  • Multi-component reaction