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Journal of the Iranian Chemical Society

, Volume 13, Issue 8, pp 1549–1560 | Cite as

Saccharin: a green, economical and efficient catalyst for the one-pot, multi-component synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole

  • Farzaneh Mohamadpour
  • Malek Taher MaghsoodlouEmail author
  • Reza Heydari
  • Mojtaba Lashkari
Original Paper

Abstract

In this method, we have reported the catalytic ability of saccharin as a green, eco-friendly catalyst for the multi-component efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and 1H-pyrazolo [1,2-b]phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole with excellent yields and short reaction times. This present methodology has notable benefits such as green, inexpensive and non-toxic catalyst, one-pot, environmental benign nature, solvent-free conditions, simplicity of operation with no necessity of chromatographic purification steps and eco-friendly.

Graphical Abstract

We have studied the catalytic ability of saccharin as a green, economical and environmentally benign nature for the multi-component efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-ones derivatives, 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole with excellent yields and short reaction times. Green catalyst, mild, non-toxic, inexpensive, simple operational procedures, one-pot, high catalytic activity, eco-friendly, easily separated from the reaction mixture with no column chromatographic for the one-pot multi-component synthesis of these compounds are the most important advantages of this procedure.

Keywords

Green synthesis Saccharin Eco-friendly 3,4-Dihydropyrimidinone 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives Dihydro-2-oxypyrrole substituted Multi-component reaction 

Notes

Acknowledgments

We gratefully acknowledge financial support from the research council of the university of Sistan and Baluchestan.

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Copyright information

© Iranian Chemical Society 2016

Authors and Affiliations

  • Farzaneh Mohamadpour
    • 1
  • Malek Taher Maghsoodlou
    • 1
    Email author
  • Reza Heydari
    • 1
  • Mojtaba Lashkari
    • 2
  1. 1.Department of Chemistry, Faculty of ScienceUniversity of Sistan and BaluchestanZahedanIran
  2. 2.Faculty of ScienceVelayat UniversityIranshahrIran

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