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Palladium complexes: new candidates for anti-cancer drugs

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Abstract

Platinum complexes which are most studied metal complexes due to their importance as adjuvant therapy of cancers aiming to induce tumor-cell-death. Some of the platinum-based antitumor drugs like cisplatin, carboplatin and oxaliplatin, have several disadvantages including side effects, cisplatin-resistant tumors, limited solubility in aqueous media, and so on. Thus, to achieve lower undesirable toxicity, enhanced solubility, and tumor selectivity, significant amount of work have been devoted to the preparation of modified platinum complexes. One of the ways to design the new anti-tumor agents related to cisplatin is to change the nature of central metal ion. Among the non-platinum metal complexes studied for cancer treatment, palladium(II) derivatives were readily chosen due to their structural analogy with those containing Pt(II) complexes. This review focuses on anti-tumor property of Pd(II) complexes and makes comparisons with similar property of cisplatin. Then, in the review, palladium(II) complexes have been classified according to their leaving ligands into palladium(II) complexes. In the last part, the most important factors affecting on the anti-tumor activity of the Pd(II) complexes were discussed. These factors are encouraging more researches in this field, for future applications.

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Acknowledgments

The financial support of Research Council of the Kharazmi University is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran

    Ehsan Zareian Jahromi & Adeleh Divsalar

  2. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

    Ali Akbar Saboury

  3. Center of Excellence in Biothermodynamics, University of Tehran, Tehran, Iran

    Ali Akbar Saboury

  4. Department of Biological Sciences, Payamenur University, Taft, Iran

    Sara Khaleghizadeh

  5. Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran

    Hassan Mansouri-Torshizi

  6. Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St., 1000, Sofia, Bulgaria

    Irena Kostova

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  1. Ehsan Zareian Jahromi
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Jahromi, E.Z., Divsalar, A., Saboury, A.A. et al. Palladium complexes: new candidates for anti-cancer drugs. J IRAN CHEM SOC 13, 967–989 (2016). https://doi.org/10.1007/s13738-015-0804-8

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