Abstract
An efficient one-pot synthesis of 2H-pyrroline derivatives by a simple reaction of β-enaminocarbonyls with arylglyoxals in water at room temperature is reported. The addition reaction between arylglyoxal derivatives and β-enaminocarbonyls in water afforded 3,4- dihydroxy-2H-pyrrolines after about 10 min stirring at room temperature. When the reaction was done in the presence of aromatic amines, the corresponding 4-amino-5-hydroxy-2H-pyrroline derivatives were obtained in good yields. All reactions were performed in water at room temperature and the products were isolated by simple filtration.
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Masoudi, M., Anary-Abbasinejad, M. & Mohammadi, M. An efficient one-pot synthesis of polyfunctionalized 2H-pyrroline derivatives by reaction of β-enaminocarbonyls, arylglyoxals and amines. J IRAN CHEM SOC 13, 315–321 (2016). https://doi.org/10.1007/s13738-015-0739-0
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DOI: https://doi.org/10.1007/s13738-015-0739-0