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Efficient synthesis of chromonylpyrano[c]coumarin, chromonylbenzo[b]pyran, and pyrano[d]pyrimidine in aqueous media

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Abstract

A novel series of functionalized heterocyclic compounds containing the chromone skeleton was achieved by a mild K2CO3 (20 %)-catalyzed one-pot three-component reaction of 3-formylchromone, malononitrile, and active methylene compounds or pyrones in aqueous media. Good to high yields, easy workup, and also environmentally friendly character are advantages for this approach.

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Acknowledgments

Saeed Balalaie gratefully acknowledges the Iran National Science Foundation (INSF) for financial support.

Author information

Authors and Affiliations

  1. Peptide Chemistry Research Center, K. N. Toosi University of Technology, P. O. Box 15875-4416, Tehran, Iran

    Hamid Reza Bijanzadeh, Saber Mehrparvar & Saeed Balalaie

  2. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Saeed Balalaie

Authors
  1. Hamid Reza Bijanzadeh
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  2. Saber Mehrparvar
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  3. Saeed Balalaie
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Corresponding author

Correspondence to Saeed Balalaie.

Additional information

Dedicated to Prof. Mohammad Ali Zolfigol on the occasion of his birthday.

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Bijanzadeh, H.R., Mehrparvar, S. & Balalaie, S. Efficient synthesis of chromonylpyrano[c]coumarin, chromonylbenzo[b]pyran, and pyrano[d]pyrimidine in aqueous media. J IRAN CHEM SOC 12, 1859–1865 (2015). https://doi.org/10.1007/s13738-015-0660-6

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  • DOI: https://doi.org/10.1007/s13738-015-0660-6

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