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A colorimetric assay for d-Penicillamine in urine and plasma samples based on the aggregation of gold nanoparticles

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Abstract

We report herein the development of a highly sensitive colorimetric method for detection of d-Penicillamine using citrate-capped gold nanoparticles (AuNPs). This assay relies upon the distance-dependent of gold nanoparticles surface plasmon resonance band of gold nanoparticles. By replacing the thiol-containing chelator drug, d-Penicillamine, with citrate on the gold nanoparticles surface, a new peak appearing at a longer wavelength intensifies and shifts further to the red from the original peak position due to aggregation of gold nanoparticles which depends on ionic strength, gold nanoparticles and d-Penicillamine concentration. During this process, the plasmon band at 521 nm decreases gradually along with the formation of a new red-shifted band at 630 nm. The calibration curve which is derived from the ratio intensities of absorbance at longer wavelength (630 nm) to original wavelength (521 nm) displays a linear relation in the range of 5.0 × 10−6–3.0 × 10−4 M d-Penicillamine. Lower limit of detection for d-Penicillamine, at the signal-to-noise ratio of 3 (3σ), was 3.8 × 10−6 M. The developed methodology was successfully applied for the determination of d-Penicillamine in human urine and plasma.

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References

  1. J.E.F. Reynolds, Martindale, The Extra Pharmacopoeia, 31st edn. (Royal Pharmaceutical Society, London, 1996)

  2. M. Mazloum-Ardakani, H. Beitollahi, Z. Taleat, H. Naeimi, N. Taghavinia, J. Electroanal. Chem. 644, 1 (2010)

    Article  CAS  Google Scholar 

  3. J.B. Raoof, R. Ojani, M. Majidian, F. Chekin, Rus. J. Electrochem. 46, 1490 (2010)

    Google Scholar 

  4. R.M. Naik, S. Prasad, B. Kumar, V. Chand, Microchem. J. 111, 97 (2013)

    Google Scholar 

  5. M. Skowron, W. Ciesielski, J. Anal. Chem. 66, 714 (2011)

    Article  CAS  Google Scholar 

  6. S.C. Liang, H. Wang, Z.M. Zhang, H.S. Zhang, Anal. Bioanal. Chem. 381, 1095 (2005)

    Article  CAS  Google Scholar 

  7. Z. Zhang, W.R.G. Baeyens, X. Zhang, Y. Zhao, G. Van Der Weken, Anal. Chim. Acta 347, 325 (1997)

    Article  CAS  Google Scholar 

  8. K. Kusmierek, G. Chwatko, R. Gowacki, P. Kubalczyk, E. Bald, J. Chromatogr. B. 879, 1290 (2011)

    Article  CAS  Google Scholar 

  9. M.A. Saracino, C. Cannistraci, F. Bugamelli, E. Morganti, I. Neri, R. Balestri, A. Patrizi, M.A. Raggi, Talanta 103, 355 (2013)

    Article  CAS  Google Scholar 

  10. K. Kusmierek, E. Bald, Anal. Chim. Acta 590, 132 (2007)

    Article  CAS  Google Scholar 

  11. M. Yusof, R. Neal, N. Aykin, N. Ercal, Biomed. Chromatogr. 14, 535 (2000)

    Article  CAS  Google Scholar 

  12. C. Burda, X. Chen, R. Narayanan, M.A. El-Sayed, Chem. Rev. 105, 1025 (2005)

    Article  CAS  Google Scholar 

  13. M. Reza Hormozi-Nezhad, J. Tashkhourian, J. Khodaveisic, M. Reza Khoshi, Anal. Methods 2, 1263 (2010)

    Article  Google Scholar 

  14. T.R. Jensen, M.D. Malinsky, C.L. Haynes, R.P. Van Duyne, J. Phys. Chem. B 104, 10549 (2000)

    Article  CAS  Google Scholar 

  15. K. Saha, S.S. Agasti, C. Kim, X. Li, V.M. Rotello, Chem. Rev. 112, 1025 (2012)

    Google Scholar 

  16. S.Y. Lin, C.H. Chen, M.C. Lin, H.F. Hsu, Anal. Chem. 77, 4821 (2005)

    Article  CAS  Google Scholar 

  17. S. Kim, J. Won Park, D. Kim, D. Kim, I. Lee, S. Jon, Angew. Chem. Int. Ed. 48, 1 (2009)

    Article  Google Scholar 

  18. D.B. Liu, W.S. Qu, W.W. Chen, W. Zhang, Z. Wang, X.Y. Jiang, Anal. Chem. 82, 9606 (2010)

    Article  CAS  Google Scholar 

  19. S. Si, A. Kotal, A.T.K. Mandal, J. Phys. Chem. C 11, 1248 (2007)

    Article  Google Scholar 

  20. L. Chen, T. Lou, C. Yu, Q. Kang, L. Chen, Analyst 136, 4770 (2011)

    Article  CAS  Google Scholar 

  21. T. Lou, L. Chen, C. Zhang, Q. Kang, H. You, D. Shen, L. Chen, Anal. Methods 4, 488 (2012)

    Article  CAS  Google Scholar 

  22. T. Lou, Z. Chen, Y. Wang, L. Chen, ACS Appl. Mater. Interfaces 3, 1568 (2011)

    Article  CAS  Google Scholar 

  23. Y.F. Zhang, B.X. Li, C.L. Xu, Analyst 135, 1579 (2010)

    Article  CAS  Google Scholar 

  24. W.L. Daniel, M.S. Han, J.S. Lee, C.A. Mirkin, J. Am. Chem. Soc. 131, 6362 (2009)

    Article  CAS  Google Scholar 

  25. M.H. Kim, S. Kim, H.H. Jang, S. Yi, S.H. Seo, M.S. Han, Tetrahedron Lett. 51, 4712 (2010)

    Article  CAS  Google Scholar 

  26. Z. Zhang, J. Zhang, C. Qu, D. Pan, Z. Chen, L. Chen, Analyst 137, 2682 (2012)

    Article  CAS  Google Scholar 

  27. L. Chen, W. Lu, X. Wang, L. Chen, Sensor Actuat. B Chem. 182, 482 (2013)

    Article  CAS  Google Scholar 

  28. X. Wang, O. Ramstrom, M.D. Yan, Anal. Chem. 82, 9082 (2010)

    Article  CAS  Google Scholar 

  29. C.L. Schofield, B. Mukhopadhyay, S.M. Hardy, M.B. McDonnell, R.A. Field, D.A. Russell, Analyst 133, 626 (2008)

    Article  CAS  Google Scholar 

  30. L. Li, B. Li, Analyst 134, 1361 (2009)

    Article  CAS  Google Scholar 

  31. M.R. Hormozi-Nezhada, B.E. Seyedhosseini, H. Robatjazi, Scientia Iranica. Trans. F Nanotech. 19, 958 (2012)

    Article  Google Scholar 

  32. N. Uehara, K. Ookubo, T. Shimizu, Langmuir 26, 6818 (2010)

    Article  CAS  Google Scholar 

  33. X.S. Liang, H.P. Wei, Z.Q. Cui, J.Y. Deng, Z.P. Zhang, X.Y. You, X.E. Zhang, Analyst 136, 179 (2011)

    Article  CAS  Google Scholar 

  34. Y. Cheng, W. Yong, J.L. Marty, Y. Xiurong, Biosens. Bioelectron. 26, 2724 (2010)

    Google Scholar 

  35. F. Xia, X.L. Zuo, R.Q. Yang, Y. Xiao, D. Kang, A. Vallee-Belisle, X. Gong, J.D. Yuen, B.B.Y. Hsu, A.J. Heeger, K.W. Plaxco, Proc. Natl. Acad. Sci. USA 107, 10837 (2010)

    Article  CAS  Google Scholar 

  36. K. Sato, K. Hosokawa, M. Maeda, Anal. Sci. 23, 17 (2007)

    Article  Google Scholar 

  37. J. Turkevich, P.C. Stevenson, J. Hillier, Discuss. Faraday Soc. 11, 55 (1951)

    Article  Google Scholar 

  38. W. Zhao, W. Chiuman, J.F.C. Lam, S.A. MacManus, W. Chen, Y. Cui, R. Pelton, M.A. Brook, Y. Li, J. Am. Chem. Soc. 130, 3610 (2008)

    Article  CAS  Google Scholar 

  39. S.K. Ghosh, S. Nath, S. Kundu, K. Esumi, T. Pal, t. J. Phys. Chem. B 108, 13963 (2004)

    Article  CAS  Google Scholar 

  40. Z.P. Li, X.R. Duan, C.H. Liu, B.A. Du, Anal. Biochem. 351, 18 (2006)

    Article  CAS  Google Scholar 

  41. I.S. Lim, W. Ip, E. Crew, P.N. Njoki, D. Mott, C.-J. Zhong, Y. Pan, S. Zhou, Langmuir 23, 826 (2007)

    Article  CAS  Google Scholar 

  42. P.K. Sudeep, S.T.S. Joseph, K.G. Thomas, J. Am. Chem. Soc. 127, 6516 (2005)

    Article  CAS  Google Scholar 

  43. K.H. Su, Q.H. Wei, X. Zhang, Nano Lett. 3, 1087 (2003)

    Article  CAS  Google Scholar 

  44. J.V. Ros-Lis, B. Garci, D. Jimenez, R. Martinez-Manez, F. Sancenon, J. Soto, F. Gonzalvo, M.C. Valldecabres, J. Am. Chem. Soc. 126, 4064 (2004)

    Article  CAS  Google Scholar 

  45. Y.V. Tcherkas, A.D. Denisenko, J. Chromatogr. A 913, 309 (2001)

    Article  CAS  Google Scholar 

  46. L. Shang, J. Yin, J. Li, S. Dong, Biosens. Bioelectron. 25, 269 (2009)

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Sharif University of Technology, 11155-9516, Tehran, Iran

    M. Reza Hormozi-Nezhad, M. Azargun & N. Fahimi-Kashani

  2. Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran

    M. Reza Hormozi-Nezhad

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  1. M. Reza Hormozi-Nezhad
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  2. M. Azargun
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  3. N. Fahimi-Kashani
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Correspondence to M. Reza Hormozi-Nezhad.

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Hormozi-Nezhad, M.R., Azargun, M. & Fahimi-Kashani, N. A colorimetric assay for d-Penicillamine in urine and plasma samples based on the aggregation of gold nanoparticles. J IRAN CHEM SOC 11, 1249–1255 (2014). https://doi.org/10.1007/s13738-013-0393-3

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  • DOI: https://doi.org/10.1007/s13738-013-0393-3

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