An efficient synthesis of new khellactone-type compounds using potassium hydroxide as catalyst via one-pot, three-component reaction

Abstract

In the present work, three-component synthesis for novel khellactone-type compounds via the reaction of Meldrum’s acid, aryl aldehydes and 5,7-dihydroxy benzopyrone derivatives was described. In this reaction 10-aryl substituted-9,10-dihydropyrano[2,3-h]benzopyrone-8-ones as new khellactone analogous in the presence of catalytic amount of potassium hydroxide as cheap and green basic catalyst were obtained in good to excellent yields under refluxing methanol.

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Acknowledgments

Financial support from Yasouj University of Iran is gratefully acknowledged.

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Correspondence to B. Karami.

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Karami, B., Eskandari, K. & Khodabakhshi, S. An efficient synthesis of new khellactone-type compounds using potassium hydroxide as catalyst via one-pot, three-component reaction. J IRAN CHEM SOC 11, 631–637 (2014). https://doi.org/10.1007/s13738-013-0333-2

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Keywords

  • Khellactone
  • Meldrum’s acid
  • 5,7-Dihydroxy benzopyrones
  • Aldehyde
  • Condensation reaction