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ZnO nanoparticle-catalyzed efficient one-pot three-component synthesis of 3,4,5-trisubstituted furan-2(5H)-ones

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Abstract

An efficient and high-yielding protocol using nano-ZnO (50–100 nm) as an efficient heterogeneous catalyst for one-pot three-component synthesis of pharmacologically significant furanone derivatives by the condensation of aromatic aldehyde, amine and dimethylacetylenedicarboxylate has been developed. Since the catalyst is heterogeneous, it can be easily separated and recycled several times without much loss of its catalytic activity. Use of aqueous medium, recyclable nanocatalyst, operational simplicity, non-chromatographic purification technique, excellent yield and short reaction time makes this approach an attractive protocol for the synthesis of 3,4,5-trisubstituted furan-2(5H)-ones.

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Acknowledgments

The authors are thankful to the Principal, Deogiri College Aurangabad, for providing laboratory facilities and constant encouragement during the work. We thank the Department of Physics, Pune University, for providing the Sophisticated Analytical and Instrument (SAIF) Facilities.

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Authors and Affiliations

  1. Department of Chemistry, Shri Muktanand College, Gangapur (MS), Maharashtra, 431 109, India

    Sunil U. Tekale, Vijay P. Pagore & Vivekanand B. Jadhav

  2. Department of Chemistry, Deogiri College, Station Road, Aurangabad, Maharashtra, 431 005, India

    Sushma S. Kauthale & Rajendra P. Pawar

Authors
  1. Sunil U. Tekale
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  2. Sushma S. Kauthale
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  3. Vijay P. Pagore
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  4. Vivekanand B. Jadhav
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Correspondence to Rajendra P. Pawar.

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Tekale, S.U., Kauthale, S.S., Pagore, V.P. et al. ZnO nanoparticle-catalyzed efficient one-pot three-component synthesis of 3,4,5-trisubstituted furan-2(5H)-ones. J IRAN CHEM SOC 10, 1271–1277 (2013). https://doi.org/10.1007/s13738-013-0266-9

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  • DOI: https://doi.org/10.1007/s13738-013-0266-9

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