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Prolinium Triflate: a protic ionic liquid which acts as water-tolerant catalyst in the alkylation of indoles

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Abstract

Prolinium triflate (ProTf) was easily prepared by addition of triflic acid to an aqueous solution of l-proline. The latter is employed as a catalyst for the condensation of indoles with aldehydes or ketones in aqueous media to form a series of bisindolyl methanes in high yields.

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Acknowledgments

I thank the Iran National Science Foundation (INSF) and Alzahra University for financial support. I also sincerely thank professor H. G. Kruger from the Catalysis and Peptide Research Unit, School of Health Sciences, UKZN, Durban, South Africa for proof-reading the manuscript and for his valuable suggestions.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Alzahra University, Vanak, 1993893973, Tehran, Iran

    Morteza Shiri

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  1. Morteza Shiri
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Correspondence to Morteza Shiri.

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Shiri, M. Prolinium Triflate: a protic ionic liquid which acts as water-tolerant catalyst in the alkylation of indoles. J IRAN CHEM SOC 10, 1019–1023 (2013). https://doi.org/10.1007/s13738-013-0239-z

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  • DOI: https://doi.org/10.1007/s13738-013-0239-z

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