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Efficient, green and regioselective synthesis of 1,4,5-trisubstituted-1,2,3-triazoles in ionic liquid [bmim]BF4 and in task-specific basic ionic liquid [bmim]OH

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Abstract

Convenient and environmentally benign procedures have been reported for the synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by the reaction of aryl azides with active methylene compounds in ionic liquid [bmim]BF4 in the presence of l-proline as a catalyst and also in task-specific basic ionic liquid [bmim]OH. The methodologies defined herein avoid the severe conditions as posed by earlier existing methods and proved to be efficient in terms of good yields, operational simplicity, easy workup and short reaction time.

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Acknowledgments

HS and JS thank UGC, New Delhi, India for the Grant of Junior Research Fellowship.

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Authors and Affiliations

  1. Department of Chemistry, University of Delhi, Delhi, 110007, India

    Harjinder Singh, Jayant Sindhu & Jitender M. Khurana

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  1. Harjinder Singh
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  2. Jayant Sindhu
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  3. Jitender M. Khurana
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Correspondence to Jitender M. Khurana.

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Singh, H., Sindhu, J. & Khurana, J.M. Efficient, green and regioselective synthesis of 1,4,5-trisubstituted-1,2,3-triazoles in ionic liquid [bmim]BF4 and in task-specific basic ionic liquid [bmim]OH. J IRAN CHEM SOC 10, 883–888 (2013). https://doi.org/10.1007/s13738-013-0224-6

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