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A simple and efficient route for the synthesis of novel isoxazolyl-2-azaspiro[4.5]deca-1,6,9-trien-8-ones

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Abstract

A new, simple and efficient method for the synthesis of novel isoxazolyl-2-azaspiro[4.5]deca-1,6,9-trien-8-ones is described by the intramolecular ipso-cyclization of 5-[(E)-2-(4-methoxyphenyl)-1-ethenyl]-3-methyl-4-nitroisoxazole with nitriles. In presence of 5-[(E)-2-(4-methoxyphenyl)-1-ethenyl]-3-methyl-4-nitroisoxazole, a variety of nitriles underwent the intramolecular ipso-cyclization smoothly, affording title compounds in moderate to good yields.

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Acknowledgments

The authors are thankful to the Head, Department of Chemistry, Kakatiya University, Warangal for providing the facilities, the Director, Indian Institute of Chemical Technology, Hyderabad for recording 1H NMR, 13C NMR and Mass Spectral data.

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  1. Department of Chemistry, Kakatiya University, Warangal, 506 009, Andhra Pradesh, India

    Rajanarendar Eligeti, Rama Krishna Saini & Raju Samala

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  1. Rajanarendar Eligeti
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  2. Rama Krishna Saini
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  3. Raju Samala
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Correspondence to Rajanarendar Eligeti.

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Eligeti, R., Saini, R. & Samala, R. A simple and efficient route for the synthesis of novel isoxazolyl-2-azaspiro[4.5]deca-1,6,9-trien-8-ones. J IRAN CHEM SOC 10, 653–658 (2013). https://doi.org/10.1007/s13738-012-0197-x

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  • DOI: https://doi.org/10.1007/s13738-012-0197-x

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