PEG–SO3H as a mild, efficient and green catalytic system for the synthesis of pyrazole derivatives in aqueous medium

Abstract

A versatile, alternative and environmentally benign strategy for the synthesis of a series of pyrazoles has been successfully performed in water using PEG–SO3H as an acidic catalyst. The products are obtained in high yield from the one-pot reaction procedure involving dicarbonyl compounds and hydrazines/hydrazides. This new method totally avoids the use of organic acids and toxic or expensive solvents in this reaction. The catalyst is waste-free, easily prepared, and efficiently re-used.

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Acknowledgments

We gratefully acknowledge the support of this work by the Birjand University Research Council.

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Correspondence to M. A. Nasseri.

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Nasseri, M.A., Alavi, S.A. & Zakeri Nasab, B. PEG–SO3H as a mild, efficient and green catalytic system for the synthesis of pyrazole derivatives in aqueous medium. J IRAN CHEM SOC 10, 213–219 (2013). https://doi.org/10.1007/s13738-012-0143-y

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Keywords

  • PEG–SO3H
  • Pyrazole
  • Hydrazine
  • Hydrazide
  • Dicarbonyl
  • Aqueous medium