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An efficient diastereoselective one-pot synthesis of functionalized dihydropyrrolo[1,2-a]quinolines

Abstract

A diastereoselective synthesis of 2-aryl-1-(cyclohexylimino)-1,2-dihydropyrrolo[1,2-a]quinoline-3,3(3aH)-dicarbonitriles is developed through a one-pot four-component reaction of malononitrile, benzaldehydes, quinoline and cyclohexyl isocyanide in a simple, mild, and efficient protocol.

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Correspondence to Issa Yavari.

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Yavari, I., Aminkhani, A. & Skoulika, S. An efficient diastereoselective one-pot synthesis of functionalized dihydropyrrolo[1,2-a]quinolines. J IRAN CHEM SOC 10, 107–111 (2013). https://doi.org/10.1007/s13738-012-0130-3

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Keywords

  • Bridgehead N-heterocycles
  • MCRs
  • Isocyanide
  • Benzaldehydes
  • Malononitrile
  • Quinoline