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Catalyst-free regioselective ring opening of epoxides with aromatic amines in water and solvent-free conditions

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Abstract

Without using any catalysts, a variety of epoxides undergo ring-opening by aromatic amines to afford the corresponding 1,2-amino alcohols in high to excellent yields with good regioselectivity in the presence of water as solvent and under solvent-free conditions.

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Scheme 1

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Notes

  1. It is difficult to distinguish in/on water in this reaction.

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Acknowledgments

We are grateful to the research council of Sharif University of Technology for financial support. We also thank the Faculty of Chemistry of Tarbiat Moallem University for supporting this work.

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Authors and Affiliations

  1. Faculty of Chemistry, Tarbiat Moallem University, P.O. Box 11465-9516, 11365, Tehran, Iran

    A. Ziyaei-Halimehjani

  2. Department of Chemistry, Sharif University of Technology, P.O. Box 11465-9516, Tehran, Iran

    H. Gholami & M. R. Saidi

Authors
  1. A. Ziyaei-Halimehjani
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  2. H. Gholami
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  3. M. R. Saidi
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Correspondence to M. R. Saidi.

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Ziyaei-Halimehjani, A., Gholami, H. & Saidi, M.R. Catalyst-free regioselective ring opening of epoxides with aromatic amines in water and solvent-free conditions. J IRAN CHEM SOC 10, 7–11 (2013). https://doi.org/10.1007/s13738-012-0122-3

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  • DOI: https://doi.org/10.1007/s13738-012-0122-3

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