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Pulmonary tumor embolism in a maintenance hemodialysis patient with hepatocellular carcinoma

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Abstract

Patients with chronic kidney disease are already at an increased risk for pulmonary embolism, since loss of renal function rendered a procoagulant state. Further, malignant tumor is a well-established risk factor for pulmonary thromboembolism. Alternatively, occlusion of the pulmonary vasculature by tumor cells per se and associated thrombi may mimic thromboembolic disease. By comparison, however, report of pulmonary tumor embolism (PTE) in patients on maintenance hemodialysis (MHD) is exceedingly rare. A less vigilant clinician may have otherwise treated this situation as fluid overload or thromboembolic disorder. We herein described in an MHD patient such an unusual case of PTE, which was diagnosed by contrast-enhanced CT and PET/CT. As such, our work may expand the knowledge reserve of dialysis staffs about this rare complication of malignancy.

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  • 28 July 2023

    The original version is updated due to spell error in corresponding author email address.

References

  1. Kumar G, Sakhuja A, Taneja A, et al. Milwaukee initiative in critical care outcomes research (MICCOR) group of investigators. Pulmonary embolism in patients with CKD and ESRD. Clin J Am Soc Nephrol. 2012;7:1584–90.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Fujieda K, Nozue A, Watanabe A, et al. Malignant tumor is the greatest risk factor for pulmonary embolism in hospitalized patients: a single-center study. Thromb J. 2021;19:77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Bassiri AG, Haghighi B, Doyle RL, Berry GJ, Rizk NW. Pulmonary tumor embolism. Am J Respir Crit Care Med. 1997;155:2089–95.

    Article  CAS  PubMed  Google Scholar 

  4. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group. KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl (2011). 2017;7:1–59.

  5. Wang T, Li Y, Wu HB, et al. Optimal blood pressure for the minimum all-cause mortality in Chinese ESRD patients on maintenance hemodialysis. Biosci Rep. 2020;40:BSR20200858.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Cheung CY, Tang SCW. Oncology in nephrology comes of age: a focus on chronic dialysis patients. Nephrology (Carlton). 2019;24:380–6.

    Article  PubMed  Google Scholar 

  7. Moroi M, Tamaki N, Nishimura M, et al. Association between abnormal myocardial fatty acid metabolism and cardiac-derived death among patients undergoing hemodialysis: results from a cohort study in Japan. Am J Kidney Dis. 2013;61:466–75.

    Article  CAS  PubMed  Google Scholar 

  8. He X, Anthony DC, Catoni Z, Cao W. Pulmonary tumor embolism: a retrospective study over a 30-year period. PLoS ONE. 2021;16: e0255917.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Khorana AA, Ahrendt SA, Ryan CK, et al. Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Clin Cancer Res. 2007;13:2870–5.

    Article  CAS  PubMed  Google Scholar 

  10. Sanghavi SF, Freidin N, Swenson ER. Concomitant lung and kidney disorders in critically ill patients: core curriculum 2022. Am J Kidney Dis. 2022;79:601–12.

    Article  PubMed  Google Scholar 

  11. Ogawa Y, Abe K, Hata K, Yamamoto T, Sakai S. A case of pulmonary tumor embolism diagnosed with respiratory distress immediately after FDG-PET/CT scan. Radiol Case Rep. 2021;16:718–22.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Wittram C, Scott JA. 18F-FDG PET of pulmonary embolism. AJR Am J Roentgenol. 2007;189:171–6.

    Article  PubMed  Google Scholar 

  13. Xi XY, Gao W, Gong JN, et al. Value of 18F-FDG PET/CT in differentiating malignancy of pulmonary artery from pulmonary thromboembolism: a cohort study and literature review. Int J Cardiovasc Imaging. 2019;35:1395–403.

    Article  PubMed  Google Scholar 

  14. Greinacher A. Clinical practice. Heparin-induced thrombocytopenia. N Engl J Med. 2015;373:252–61.

    Article  CAS  PubMed  Google Scholar 

  15. Lin HH, Hsieh CB, Chu HC, Chang WK, Chao YC, Hsieh TY. Acute pulmonary embolism as the first manifestation of hepatocellular carcinoma complicated with tumor thrombi in the inferior vena cava: surgery or not? Dig Dis Sci. 2007;52:1554–7.

    Article  PubMed  Google Scholar 

  16. Sung AD, Cheng S, Moslehi J, Scully EP, Prior JM, Loscalzo J. Hepatocellular carcinoma with intracavitary cardiac involvement: a case report and review of the literature. Am J Cardiol. 2008;102:643–5.

    Article  PubMed  Google Scholar 

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Correspondence to Tao Wang.

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All the authors have declared no competing interest.

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All procedures performed in our study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from the patient included in the study.

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Li, J., Zhao, Z., Ren, G. et al. Pulmonary tumor embolism in a maintenance hemodialysis patient with hepatocellular carcinoma. CEN Case Rep 13, 121–124 (2024). https://doi.org/10.1007/s13730-023-00810-w

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  • DOI: https://doi.org/10.1007/s13730-023-00810-w

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