Abstract
Cyst infection is a frequent and serious complication of autosomal dominant polycystic kidney disease (ADPKD). Hematogenous spread via bacterial translocation in the intestine is considered to be the main cause, so intestinal flora may be involved. However, the exact role of the intestinal flora in cyst infection in ADPKD is unknown. We report a 66-year-old woman and a 56-year-old man with ADPKD who had severe hepatic cyst infection. We analyzed the microbiome of infected cyst content, feces, and saliva in these two patients. The microbiome of patient 1 showed various bacteria in an infected cyst, whereas that of patient 2 showed only one bacterium. In both patients, the composition of the microbiome of the cyst content was quite different from those of feces and saliva, and the main bacteria in the infected cyst content represented a small proportion of those in feces and saliva. Lactobacilli were not almost detected in the infected cyst content though some lactobacilli are endemic in the gastrointestinal tract and the saliva. The association between bacteria in cysts and those in feces or saliva remains uncertain, and further research on this topic is needed.
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Acknowledgements
This manuscript was checked for language content by a native English-speaking medical editor at Yamada Translation Bureau, Inc. (Tokyo, Japan).
Funding
This work was supported by Grants-in-Aid for Scientific Research from Japan Society for the Promotion of Science (JSPS KAKENHI Grant number JP18K08227 and JP19K17758). This study was also supported in part by a Grant-in-Aid for Progressive Renal Disease Research from the Ministry of Health, Labour and Welfare of Japan and by Okinaka Memorial Institute for Medical Research, Toranomon Hospital.
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The study was approved by the Institutional review board of Toranomon Hospital.
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13730_2022_767_MOESM2_ESM.xlsx
Supplementary file2 Additional File 2 of Microbiome of infected cysts, feces and saliva in patients with autosomal dominant polycystic kidney disease: case reports. The analysis of the microbiome of infected cysts, feces, and saliva in the patients of Case 1. (XLSX 14 KB)
13730_2022_767_MOESM3_ESM.xlsx
Supplementary file3 Additional File 3 of Microbiome of infected cysts, feces and saliva in patients with autosomal dominant polycystic kidney disease: case reports. The analysis of the microbiome of infected cysts, feces, and saliva in the patients of Case 2. (XLSX 14 KB)
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Suwabe, T., Morita, H., Khasnobish, A. et al. Microbiome of infected cysts, feces and saliva in patients with autosomal dominant polycystic kidney disease. CEN Case Rep 12, 304–310 (2023). https://doi.org/10.1007/s13730-022-00767-2
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DOI: https://doi.org/10.1007/s13730-022-00767-2