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Denileukin diftitox-induced systemic capillary leak syndrome with acute kidney injury

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Abstract

Systemic capillary leak syndrome is a rare and life-threatening disorder, characterized by recurrent episodes of unexplained hypotension, hemoconcentration, and hypoalbuminemia. This condition is caused by leakage of plasma and proteins into the extravascular space and can be classified as either idiopathic or secondary. Secondary systemic capillary leak syndrome can result from cancer, infections, medications, or surgery. Systemic capillary leak syndrome frequently develops as a side effect of denileukin diftitox treatment of refractory cutaneous T-cell lymphoma. However, the pathophysiology of this disease is not well understood. Herein, we report a case of denileukin diftitox-induced systemic capillary leak syndrome.

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Authors and Affiliations

  1. Department of Endocrinology, Metabolism and Nephrology, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan

    Taro Horino, Daiki Okada, Satoshi Inotani & Yoshio Terada

  2. Department of Dermatology, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan

    Hideki Nakajima

  3. Department of Otolaryngology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan

    Masahiro Komori

Authors
  1. Taro Horino
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  2. Daiki Okada
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  3. Satoshi Inotani
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  4. Hideki Nakajima
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  5. Masahiro Komori
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  6. Yoshio Terada
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Correspondence to Taro Horino.

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Horino, T., Okada, D., Inotani, S. et al. Denileukin diftitox-induced systemic capillary leak syndrome with acute kidney injury. CEN Case Rep 12, 63–67 (2023). https://doi.org/10.1007/s13730-022-00720-3

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  • DOI: https://doi.org/10.1007/s13730-022-00720-3

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