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Catastrophic antiphospholipid antibody syndrome as a first manifestation of primary antiphospholipid antibody syndrome in a middle-aged man

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Abstract

Catastrophic antiphospholipid antibody syndrome (CAPS) is a severe form of antiphospholipid antibody syndrome (APS) that sometimes represents the first manifestation of the later syndrome. The clinical manifestations of CAPS are relatively non-specific. Hence, the diagnosis may be delayed, resulting in high mortality. We herein present a case of a 40-year-old male who presented with rapid-onset renal failure, gangrene of finger and toe tips and hematological abnormalities with no underlying secondary cause for this complication. The symptoms were precipitated by febrile illness of short duration. A provisional diagnosis of CAPS was made and treatment instituted. With timely diagnosis and intervention, both the life of the patient and kidney function were salvaged. A high index of suspicion for CAPS is important as early treatment can be lifesaving.

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Authors and Affiliations

  1. Department of Nephrology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, 74200, Pakistan

    Nazrul Hassan Jafry, Ejaz Ahmed & Fazal Akhtar

  2. Department of Pathology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, 74200, Pakistan

    Muhammed Mubarak

Authors
  1. Nazrul Hassan Jafry
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  2. Muhammed Mubarak
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  3. Ejaz Ahmed
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  4. Fazal Akhtar
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Correspondence to Nazrul Hassan Jafry.

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All procedures performed in this case report were in accordance with the ethical standards of the institutional committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Jafry, N.H., Mubarak, M., Ahmed, E. et al. Catastrophic antiphospholipid antibody syndrome as a first manifestation of primary antiphospholipid antibody syndrome in a middle-aged man. CEN Case Rep 9, 152–158 (2020). https://doi.org/10.1007/s13730-020-00446-0

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  • DOI: https://doi.org/10.1007/s13730-020-00446-0

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