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A case of a maintenance hemodialysis patient with autosomal dominant polycystic kidney disease who underwent living donor liver transplantation alone due to refractory liver cyst infection

CEN Case Reports volume 7, pages 307–312 (2018)Cite this article

Abstract

Liver cysts are observed in 83% of cases of autosomal dominant polycystic kidney disease (ADPKD). Although not as prevalent as renal cyst infection, liver cyst infection is a serious complication that is sometimes difficult to treat. We report the case of a maintenance hemodialysis patient with ADPKD who received a living donor liver transplantation alone (LDLTA) due to refractory liver cyst infection. The patient was a 67-year-old Japanese man who developed fever and right-side abdominal pain, and liver cyst infection was suspected. Treatment with multiple antibiotics was ineffective. Many liver cysts were observed on magnetic resonance imaging scans and a cyst in liver segment S6, which produced the strongest signal variation, was drained. The fever subsided temporarily, but multiple infected liver cysts were observed on follow-up imaging examination; 4 months later, hepatectomy and LDLTA were performed. Although LDLTA due to refractory liver cyst infection in maintenance hemodialysis patients with ADPKD is risky and should be carefully considered, it may be the only effective treatment.

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Acknowledgements

This report was supported in part by a Grant-in-Aid for Intractable Renal Diseases Research, Research on rare and intractable diseases; and Health and Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare of Japan.

Author information

Affiliations

  1. Department of Medicine, Kidney Center, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Taro Akihisa, Ayami Ino, Kosaku Nitta & Toshio Mochizuki

  2. Department of Surgery, Institute of Gastroenterology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Hiroto Egawa, Yoshihito Kotera, Shunichi Ariizumi, Akiko Oomori, Shingo Yamashita & Masakazu Yamamoto

  3. Department of Plastic and Reconstructive Surgery, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Yusuke Yamamoto

  4. Department of Blood Purification, Kidney Center, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Ken Tsuchiya

  5. Clinical Research Division for Polycystic Kidney Disease, Department of Medicine, Kidney Center, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Toshio Mochizuki

Authors
  1. Taro Akihisa
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  2. Ayami Ino
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  3. Hiroto Egawa
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  4. Yoshihito Kotera
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  5. Shunichi Ariizumi
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  6. Akiko Oomori
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  7. Shingo Yamashita
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  8. Yusuke Yamamoto
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  9. Ken Tsuchiya
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  10. Masakazu Yamamoto
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  11. Kosaku Nitta
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  12. Toshio Mochizuki
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Corresponding author

Correspondence to Toshio Mochizuki.

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Conflict of interest

Toshio Mochizuki and Ken Tsuchiya received travel fees and honoraria for lectures from Otsuka Pharmaceutical Co. Toshio Mochizuki belongs to an endowed university department sponsored by Otsuka Pharmaceutical Co, Chugai Pharmaceutical Co, Kyowa Hakko Kirin Co, MSD Co, and JMS Co.

Ethical approval

All procedures performed in the patient study were in accordance with the 1964 Helsinki Declaration and its later amendments, or with comparable ethical standards.

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Informed consent was obtained from the patient.

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Cite this article

Akihisa, T., Ino, A., Egawa, H. et al. A case of a maintenance hemodialysis patient with autosomal dominant polycystic kidney disease who underwent living donor liver transplantation alone due to refractory liver cyst infection. CEN Case Rep 7, 307–312 (2018). https://doi.org/10.1007/s13730-018-0348-8

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  • DOI: https://doi.org/10.1007/s13730-018-0348-8

Keywords

  • Liver transplantation
  • Hemodialysis
  • ADPKD
  • Polycystic kidney disease
  • Polycystic liver disease
  • Liver cyst infection