CEN Case Reports

, Volume 7, Issue 1, pp 143–147 | Cite as

A case of unilateral nephrectomy performed for autosomal dominant polycystic kidney disease with marked unilateral enlargement

  • Shiho Makabe
  • Hiroshi Kataoka
  • Tsunenori Kondo
  • Kazunari Tanabe
  • Ken Tsuchiya
  • Kosaku Nitta
  • Toshio Mochizuki
Case Report

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the occurrence of multiple cysts that increase the size of both kidneys, progressively reducing kidney function. Usually the cysts occur bilaterally, and there is no difference in the degree of cyst enlargement between the left and right. Here, we report a case of ADPKD in which kidney size increased markedly on the left side and was accompanied by severe abdominal distension and discomfort. Renal dynamic scintigraphy revealed a severe reduction in function of the left kidney compared with the right. Open left nephrectomy was performed. No change in renal function was observed postoperatively [preoperative estimated glomerular filtration rate (eGFR): 57.6 mL/min/1.73 m2, 3-month postoperative eGFR: 56.4 mL/min/1.73 m2], and the abdominal symptoms subsided. When one kidney is markedly larger than the other, the cause and status of the laterality should be evaluated by using renal dynamic scintigraphy in addition to other examinations such as computed tomography or magnetic resonance imaging. Unilateral nephrectomy should be considered as a potential treatment.

Keywords

Autosomal dominant polycystic kidney disease ADPKD Unilateral nephrectomy Renal dynamic scintigraphy 

Notes

Compliance with ethical standards

Conflict of interest

Toshio Mochizuki and Ken Tsuchiya received travel fees and honoraria for lectures from Otsuka Pharmaceutical Co. Toshio Mochizuki and Hiroshi Kataoka belong to an endowed university department sponsored by Otsuka Pharmaceutical Co, Chugai Pharmaceutical Co, Kyowa Hakko Kirin Co, MSD Co, and JMS Co.

Ethical approval

All procedures performed in the patient study were in accordance with the 1964 Helsinki Declaration and its later amendments, or with comparable ethical standards.

Informed consent

Informed consent was obtained from the patient.

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Copyright information

© Japanese Society of Nephrology 2018

Authors and Affiliations

  • Shiho Makabe
    • 1
  • Hiroshi Kataoka
    • 1
    • 2
  • Tsunenori Kondo
    • 3
  • Kazunari Tanabe
    • 4
  • Ken Tsuchiya
    • 5
  • Kosaku Nitta
    • 1
  • Toshio Mochizuki
    • 1
    • 2
  1. 1.Department of Medicine, Kidney CenterTokyo Women’s Medical UniversityTokyoJapan
  2. 2.Clinical Research Division for Polycystic Kidney Disease, Department of Medicine, Kidney CenterTokyo Women’s Medical UniversityTokyoJapan
  3. 3.Department of UrologyTokyo Women’s Medical University Medical Center EastTokyoJapan
  4. 4.Department of Urology, Kidney CenterTokyo Women’s Medical UniversityTokyoJapan
  5. 5.Department of Blood Purification, Kidney CenterTokyo Women’s Medical UniversityTokyoJapan

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