CEN Case Reports

, Volume 7, Issue 1, pp 132–136 | Cite as

Advanced native-kidney carcinoma in a heart- and kidney-transplanted patient: a case report

  • Matteo Paoletti
  • Barbara Cattadori
  • Marilena Gregorini
  • Alessandra Viglio
  • Giovanni Gentile
  • Andrea Maria D’Armini
  • Carlo Pellegrini
  • Alfredo La Fianza
Case Report


Malignancies are one of the leading causes of death in long-term surviving transplant recipients. Dose and prolonged durations of immunosuppressive regimens are considered the main cause, through a direct oncogenic effect and a renowned interaction on physiological anti-viral and anti-oncogenic immune response. Specific neoplasms are known to occur with different frequencies according to the transplanted organ. As a consequence, imaging screenings have been implemented in many graft surveillance programs, although a wide consensus on the timing and modality has not been concurred. There are little data available in the literature regarding incidence of de-novo malignancies in multi-organ recipients. We report the case of a 66-year-old man who developed a renal mass 10 years after a combined heart–kidney transplant.


Cancer screening Immunosuppression Kidney transplantation Heart transplantation Post-transplant malignancy 


Compliance with ethical standards

Conflict of interest

All the authors have declared no competing interests.

Human participants and animal rights statement

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from the patient included in this article.


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Copyright information

© Japanese Society of Nephrology 2018

Authors and Affiliations

  • Matteo Paoletti
    • 1
  • Barbara Cattadori
    • 2
  • Marilena Gregorini
    • 3
  • Alessandra Viglio
    • 4
  • Giovanni Gentile
    • 1
  • Andrea Maria D’Armini
    • 2
    • 5
    • 6
  • Carlo Pellegrini
    • 2
    • 5
    • 6
  • Alfredo La Fianza
    • 1
  1. 1.Institute of RadiologyIRCCS Policlinico San Matteo, University of PaviaPaviaItaly
  2. 2.Department of Cardiac SurgeryIRCCS Policlinico San MatteoPaviaItaly
  3. 3.Nephrology, Dialysis and Transplant UnitIRCCS Policlinico San Matteo, University of PaviaPaviaItaly
  4. 4.Department of PathologyIRCCS Policlinico San Matteo; University of PaviaPaviaItaly
  5. 5.School of “Cardiovascular Pathophysiology, Cardiac Perfusion”University of PaviaPaviaItaly
  6. 6.Chair of Cardiac SurgeryUniversity of PaviaPaviaItaly

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