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CEN Case Reports

, Volume 7, Issue 1, pp 178–179 | Cite as

Prolonged renal allograft survival without immunosuppressive therapy

  • Abhilash Koratala
  • Kawther F. Alquadan
Letter to the Editor

To the Editor,

A 47-year-old White man with a history of renal transplantation was seen in the Nephrology clinic for worsening renal function and proteinuria. He was born with a single kidney with anatomic abnormalities leading to frequent urinary tract infections and end-stage renal disease by age 16. At that time, he received a kidney transplant from a deceased donor, but the allograft failed in 6 years, apparently due to cyclosporine toxicity. At age 22, he received a living-related kidney transplant from his sister. There were 3 out of 6 HLA loci mismatches, one each for A, B and DR between the patient and his sister and he received induction therapy with anti-thymocyte globulin. 4 years later, he had allograft nephrectomy of the first transplant due to pain and shortly thereafter, he stopped taking all his immunosuppressive medications because he lost his insurance and could not afford them. He had no kidney-related issues or hospitalizations for the next 20 years, and 1 year...

Notes

Compliance with ethical standards

Conflict of interest

The authors have declared that no conflict of interest exists.

Human and animal rights (with IRB approval number)

This article does not contain any studies with human participants or animals performed by any of the authors. IRB approval is not applicable for a letter/single case study.

Registration of clinical trials

Not applicable.

Informed consent

Informed consent was obtained for the publication of this case study.

References

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    Hanf W, Bonder CS, Coates PT. Transplant glomerulopathy: the interaction of HLA antibodies and endothelium. J Immunol Res. 2014;2014:549315.CrossRefPubMedPubMedCentralGoogle Scholar
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    Filippone EJ, McCue PA, Farber JL. Transplant glomerulopathy. Mod Pathol. 2017.  https://doi.org/10.1038/modpathol.PubMedGoogle Scholar
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    Roussey-Kesler G, Giral M, Moreau A, Subra JF, et al. Clinical operational tolerance after kidney transplantation. Am J Transplant. 2006;6(4):736 – 46.CrossRefPubMedGoogle Scholar

Copyright information

© Japanese Society of Nephrology 2017

Authors and Affiliations

  1. 1.Division of Nephrology, Hypertension and Renal TransplantationUniversity of FloridaGainesvilleUSA
  2. 2.College of Medicine/UF HealthGainesvilleUSA

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