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Renal hemorrhage caused by acquired inhibitors to coagulation factors VIII and V in a hemodialysis patient

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Abstract

Acquired coagulation factor deficiency is a rare bleeding disorder caused by the inhibitors to coagulation factors. We report a case of an elderly hemodialysis patient who presented with the intermittent hematuria and anemia, associated with the prolonged activated partial thromboplastin time and prothrombin time. Laboratory examination revealed undetectable factor VIII activity, decreased factor V activity, and the presence of inhibitors to these coagulation factors. The patient was diagnosed to have inhibitors to coagulation factors VIII and V simultaneously. In addition, hematuria was found to be caused by the right renal hemorrhage. Renal extravasation was treated by transcatheter arterial embolization. Oral prednisolone successfully eradicated the inhibitors. The present case highlights the importance to consider acquired coagulation factor inhibitors for bleeding symptoms, because they are sometimes life-threatening.

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Authors and Affiliations

  1. Apheresis and Dialysis Center, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Naoya Niwa, Tadashi Yoshida & Matsuhiko Hayashi

  2. Department of Urology, School of Medicine, Keio University, Tokyo, Japan

    Naoya Niwa, Ryuichi Mizuno & Mototsugu Oya

  3. Department of General Medicine, School of Medicine, Keio University, Tokyo, Japan

    Tadashi Yoshida & Matsuhiko Hayashi

Authors
  1. Naoya Niwa
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  2. Tadashi Yoshida
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  3. Ryuichi Mizuno
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  4. Mototsugu Oya
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  5. Matsuhiko Hayashi
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Corresponding author

Correspondence to Tadashi Yoshida.

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The authors have declared that no conflict of interest exists.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Niwa, N., Yoshida, T., Mizuno, R. et al. Renal hemorrhage caused by acquired inhibitors to coagulation factors VIII and V in a hemodialysis patient. CEN Case Rep 5, 223–226 (2016). https://doi.org/10.1007/s13730-016-0229-y

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  • DOI: https://doi.org/10.1007/s13730-016-0229-y

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