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Renal cell neoplasm of oncocytosis: a type of unclassified renal cell carcinoma

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Abstract

A 69-year-old woman was referred to us because a cyst in the lower pole of the left kidney had been pointed out on screening ultrasound. Computed tomography (CT) demonstrated a mural nodule of the wall of the cyst with an enhancement effect, suggesting cystic renal cell carcinoma (cT1aN0M0). The patient underwent retroperitoneoscopic non-ischemic partial nephrectomy using a microwave tissue coagulator. A hematoxylin–eosin-stained specimen showed that the wall of the cystic tumor consisted of the proliferation of large cells with rich eosinophilic granules in the cytoplasm and round-shaped nuclei, which were the characteristics of oncocytoma. This was followed by immunohistochemical studies, because of findings of local cell invasion, mitosis, and necrosis, suggesting malignancy. The results were: CK7, strongly positive; PAX2, negative; colloidal iron stain, negative; c-kit, weakly positive; vimentin, positive; and RCC marker, negative. Thus, although the tumor showed characteristics of oncocytoma and/or chromophobe renal cell carcinoma (pT1a), it could not be classified according to the known categories: it should be designated as renal cell carcinoma (neoplasm) of oncocytosis, a novel category of unclassified renal cell carcinomas. The present case indicated the fact that renal cell carcinomas resembling oncocytoma certainly exist.

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The authors have declared that no conflict of interest exists.

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Authors and Affiliations

  1. Department of Urology, Nara Prefectural Nara Hospital, 1-30-1 Hiramatsu, Nara, Nara, 631-0846, Japan

    Masatake Shinohara, Shoji Samma, Yoshihiro Matsumoto, Yoriaki Kagebayashi & Yasushi Nakai

  2. Department of Urology, Nara Medical University, Nara, Japan

    Kazumasa Torimoto

  3. Department of Pathology, Nara Medical University, Nara, Japan

    Keiji Shimada

Authors
  1. Masatake Shinohara
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  2. Shoji Samma
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  3. Yoshihiro Matsumoto
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  4. Yoriaki Kagebayashi
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  5. Yasushi Nakai
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  6. Kazumasa Torimoto
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  7. Keiji Shimada
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Corresponding author

Correspondence to Shoji Samma.

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Shinohara, M., Samma, S., Matsumoto, Y. et al. Renal cell neoplasm of oncocytosis: a type of unclassified renal cell carcinoma. CEN Case Rep 3, 10–13 (2014). https://doi.org/10.1007/s13730-013-0075-0

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  • DOI: https://doi.org/10.1007/s13730-013-0075-0

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