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Identification of blood-based inflammatory biomarkers for the early-stage detection of acute myocardial infarction

Abstract

Acute myocardial infarction (AMI) is a coronary artery disease that prevents blood and oxygen flow from reaching the heart. The underlying complex pathophysiology of AMI has made the early detection process very challenging. A potential biomarker with high accuracy in determining AMI can help us in the risk stratification of patients with chest pain and also reduce treatment costs. This study aimed to identify the key genes for early AMI detection from the expression data of peripheral blood samples. We retrieved three GEO datasets from NCBI that represent expression data of healthy individuals and early-stage AMI patients. The differentially expressed genes (DEG) were determined from three datasets by the GEO2R tool on the NCBI webpage. The significant DEGs common in at least 2 datasets were identified by VENNY 2.1 web tool. We then performed a functional enrichment analysis of the selected genes and also the potential hub genes possibly involved in AMI were predicted by a protein–protein interaction network. Finally, a drug–gene interaction network was constructed. We found 5360, 2049, and 579 genes, respectively, from the GSE61144, GSE60993, and GSE29532 datasets to be the significant DEGs in GEO2R analysis. A total of 214 genes were found common in at least two datasets. CD59, FCAR, CLEC5A, CKAP4, and CEACAM8 are the most significant hub genes predicted by protein–protein network analysis that has a close relationship with the early response to inflammation in AMI. Our study suggests CD59, FCAR, CLEC5A, CKAP4, and CEACAM8 as the potential inflammatory biomarkers for the early-stage detection of AMI.

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The datasets supporting the conclusions of this study are included within the article (and its additional files).

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MTS, SS, PB, MTI, MNH carried out the data analysis, bioinformatics analysis, interpreted the results and wrote the article. MAS, MOR contributed to the bioinformatics analysis and revised the article. MTS, MOR, contributed to the interpretation of the results and revised the article. MTS, SS, PB, MOR, NI, and MMIR examined the literature and prepare the figures. MTS, SS, PB, NI, MMIR, and MOR contributed to the interpretation of the results and revised the manuscript. All authors contributed to the article and approved the submitted version.

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Correspondence to Md. Oliullah Rafi.

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The authors declare no competing interests.

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Sarker, M.T., Saha, S., Biswas, P. et al. Identification of blood-based inflammatory biomarkers for the early-stage detection of acute myocardial infarction. Netw Model Anal Health Inform Bioinforma 11, 28 (2022). https://doi.org/10.1007/s13721-022-00371-5

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  • DOI: https://doi.org/10.1007/s13721-022-00371-5

Keywords

  • Acute myocardial infarction
  • Biomarker
  • Differentially expressed gene
  • Hub gene
  • Inflammation