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Molecular modeling and phylogenetic analysis of Esx homeobox-1 protein of Bubalus bubalis

Abstract

ESX-1 is an X-linked gene, which encodes for a homeobox protein. The ESX-1 expressed specifically in extra-embryonic tissues during development and in the adult testis as well. In the present study, we have predicted the three-dimensional structure of ESX-1 homeobox protein of Bubalus bubalis using homology modeling. The predicted model further explored for identification of ligand binding sites, which may be useful for understanding specific role in functional site residues during catalysis. This study also demonstrated the phylogenetic analysis of ESX-1 homeobox protein of B. bubalis with different similar species. The ESX-1 homeobox protein of B. bubalis has shown similarity with Bos taurus, Ovis aries and Capra hircus species.

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We appreciate reviewers valuable suggestions and comments.

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Correspondence to Vijay Tripathi.

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Tripathi, P., Yadav, B.S. & Tripathi, V. Molecular modeling and phylogenetic analysis of Esx homeobox-1 protein of Bubalus bubalis . Netw Model Anal Health Inform Bioinforma 3, 57 (2014). https://doi.org/10.1007/s13721-014-0057-y

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  • DOI: https://doi.org/10.1007/s13721-014-0057-y

Keywords

  • ESX-1 homeobox protein
  • Bubalus bubalis
  • Homology modeling
  • Phylogenetic analysis