Skip to main content
Log in

A rare case of ovarian gonadoblastoma flourishing into malignant mixed germ cell tumour with review of literature

  • Case report
  • Published:
International Cancer Conference Journal Aims and scope Submit manuscript

Abstract

Gonadoblastoma is an extremely rare neoplasm of the ovary showing admixture of germ cells and sex cord cells. It may be associated with gonadal dysgenesis. Gonadoblastoma cells may give rise to individual germ cell tumours or mixed germ cell tumours with variable tumour components. Very few cases of ovarian gonadoblastoma admixed with malignant germ cell tumours have been recorded worldwide. Because of the rareness of the tumour, a component of gonadoblastoma might be overlooked on microscopic examination. Here we report a rare case of ovarian gonadoblastoma giving rise to an admixture of immature teratoma and dysgerminoma. We discuss microscopic features, immunohistochemistry findings and review of literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Scully RE (1970) Gonadoblastoma. A review of 74 cases. Cancer 25:1340–1356

    Article  CAS  Google Scholar 

  2. Ulbright TM, Kao CS. Gonadoblastoma. In: Cheung AN, Ellenson LH, Gilks CB, Kim K-R, Kong CS, Lax SF, Longacre TA et al (eds) (2020) Tumours of ovary. In WHO classification of female genital tumours, 5th ed, vol 70. WHO Classification of Tumours Editorial Board, International Agency for Research on Cancer (IARC), Lyon, pp 140–142

  3. Zaloudek C, Vang R. Mixed Germ Cell Tumour of the Ovary. In: Cheung AN, Ellenson LH, Gilks CB, Kim K-R, Kong CS, Lax SF, Longacre TA et al (eds) (2020) Tumours of ovary. In: WHO classification of female genital tumours, 5th edn, vol 70. WHO Classification of Tumours Editorial Board, International Agency for Research on Cancer (IARC), Lyon, p 131

  4. Hart WR, Burkons DM (1979) Germ cell neoplasms arising in gonadoblastomas. Cancer 43(2):669–678

    Article  CAS  Google Scholar 

  5. Arafah MA, Raddaoui LE (2018) Malignant mixed germ cell tumour overgrowing a gonadoblastoma in a female with a 46, XX karyotype: a case report. Int J Surg Pathol 26(3):287–292

    Article  Google Scholar 

  6. Gru AA, Williams ES, Cao D (2017) Mixed gonadal germ cell tumour composed of a spermatocytic tumour-like component and germinoma arising in gonadoblastoma in a phenotypic woman with a 46, XX peripheral karyotype: report of the first case. Am J Surg Pathol 41(9):1290–1297

    Article  Google Scholar 

  7. Losada DM, Benetti-Pinto CL, Andrade LALA (2019) Gonadoblastoma-associated mixed gonadal germ cell tumour with dysgerminoma and hepatoid yolk sac tumour components in 46xy gonadal dysgenesis. J Pediatr Adolesc Gynecol 32(5):558–560

    Article  Google Scholar 

  8. Zhu HL, Bao DM, Wang Y, Shen DH, Li Y, Cui H (2016) Swyer’s syndrome with mixed ovarian malignant germ cell tumour and ovarian gonadoblastoma. Chin Med J (Engl) 129(14):1752–1754

    Article  Google Scholar 

  9. Kulkarni MM, Khandeparkar SG, Joshi AR, Bhayekar PV (2016) Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: extremely rare occurrence with characteristic immunohistomorphology. Indian J Pathol Microbiol 59:527–529

    Article  Google Scholar 

  10. Yüce Ö, Döğer E, Çelik N, Emeksiz HC, Çamurdan MO, Bideci A, Cinaz P (2015) Gonadoblastoma with dysgerminoma in a phenotypically turner-like girl with 45, X/46, XY karyotype. J Clin Res Pediatr Endocrinol 7(4):336–339

    Article  Google Scholar 

  11. Ulbright TM (2014) Gonadoblastoma and hepatoid and endometrioid-like yolk sac tumour: an update. Int J Gynecol Pathol 33(4):365–373

    Article  CAS  Google Scholar 

  12. Piazza MJ, Urbanetz AA (2019) Germ cell tumours in dysgenetic gonads. Clinics (Sao Paulo) 74:e408

    Article  Google Scholar 

  13. Talerman A, Roth LM (2007) Recent advances in the pathology and classification of gonadal neoplasms composed of germ cells and sex cord derivatives. Int J Gynecol Pathol 26:313–321

    Article  Google Scholar 

  14. Palma I, Garibay N, Pena-Yolanda R, Contreras A, Raya A, Dominguez C, Romero M, Aristi G, Queipo G (2013) Utility of OCT3/4, TSPY and β-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumour development in dysgenetic gonads. Dis Markers 34(6):419–424

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tarang Patel.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Patel, T., Jakhetiya, B., Jakhetiya, A. et al. A rare case of ovarian gonadoblastoma flourishing into malignant mixed germ cell tumour with review of literature. Int Canc Conf J 11, 114–118 (2022). https://doi.org/10.1007/s13691-021-00531-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13691-021-00531-w

Keywords

Navigation