Skip to main content
SpringerLink
Log in

Primary undifferentiated carcinoma with osteoclast-like giant cells in liver and rapidly developing multiple metastases after curative hepatectomy: a case report

  • Case report
  • Published:
International Cancer Conference Journal Aims and scope Submit manuscript

Abstract

A 64-year-old man was diagnosed with cholangiocellular carcinoma based on preoperative computed tomography and magnetic resonance imaging and underwent laparoscopic segmentectomy (Segment 8) of the liver for radical operation. Pathological examination revealed the presence of an undifferentiated carcinoma with osteoclast-like giant cells, which were categorized as T3N0M0 and Stage III based on the third English edition of the Japanese classification of liver cancer. The patient was treated with three courses of combination chemotherapy, which included gemcitabine (1000 mg/m2) and cisplatin (25 mg/m2), as well as S-1 (120 mg/day) for adjuvant chemotherapy. At two months after the operation, CT revealed multiple liver- and lung metastases. Thereafter, the patient was prescribed the molecularly targeted drug, lenvatinib (12 mg/day). However, lenvatinib was not effective, as evident by the extension of several metastases. Testing for microsatellite instability was negative. The patient died 5 months after the operation. We experienced a case of primary undifferentiated carcinoma with osteoclast-like giant cells in the liver showed rapidly developing multiple metastases after curative liver resection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Nakasuka H, Okada S, Okusaka T et al (1998) Undifferentiated carcinoma of the liver with neuroendocrine features: a case report. Jpn J Clin Oncol 28:401–404

    Article  CAS  Google Scholar 

  2. Hiraki M, Kitahara K, Miyoshi A et al (2018) A long-term survivor of undifferentiated carcinoma of the liver successfully treated with surgical treatments: a case report and literature review. Int J Surg Case Rep 51:45–49

    Article  Google Scholar 

  3. Maeda T, Kayashima H, Imai D et al (2017) Undifferentiated carcinoma of the liver: a case report with immunohistochemical analysis. Surg Case Rep 3:12

    Article  Google Scholar 

  4. Kubo M, Kitano M, Sakurai T et al (2015) General rules for the clinical and pathological study of primary liver cancer. Nationwide follow-up survey and clinical practice guidelines: the outstanding achievements of the liver cancer study group of Japan. Dig Dis 33:765–770

    Article  Google Scholar 

  5. Bosman FT, Cameiro F, Hruban RH et al (2010) WHO classification of tumours of the digestive system, vol 3, 4th edn. International Agency for Research on Cancer, Lyon

    Google Scholar 

  6. Ananthakrishnan A, Gogineni V, Saeian K (2006) Epidemiology of primary and secondary liver cancers. Semin Intervent Radiol 23:47–63

    Article  Google Scholar 

  7. Livraghi T, Mäksalo H, Line PD (2011) Treatment options in hepatocellular carcinoma today. Scand J Surg 100:22–29

    Article  CAS  Google Scholar 

  8. Forner A, Reig M, Bruix J (2018) Hepatocellular carcinoma. Lancet 391:1301–1314

    Article  Google Scholar 

  9. Villanueva A (2019) Hepatocellular carcinoma. N Engl J Med 381:e2

    Article  Google Scholar 

  10. Munoz PA, Rao MS, Reddy JK (1980) Osteoclastoma-like giant cell tumor of the liver. Cancer 46:771–779

    Article  CAS  Google Scholar 

  11. Andreola S, Lombardi L, Scurelli A et al (1985) Osteoclastoma-like giant-cell tumor of the liver. Case Rep Tumori 71:615–620

    CAS  Google Scholar 

  12. Horie Y, Hori T, Hirayama C et al (1987) Osteoclast-like giant cell tumor of the liver. Acta Pathol Jpn 37:1327–1335

    CAS  PubMed  Google Scholar 

  13. McCluggage WG, Toner PG (1993) Hepatocellular carcinoma with osteoclast-like giant cells. Histopathology 23:187–189

    Article  CAS  Google Scholar 

  14. Sasaki A, Yokoyama S, Nakayama I et al (1997) Sarcomatoid hepatocellular carcinoma with osteoclast-like giant cells: case report and immunohistochemical observations. Pathol Int 47:318–324

    Article  CAS  Google Scholar 

  15. Ahaouche M, Cazals-Hatem D, Sommacale D et al (2005) A malignant hepatic tumour with osteoclast-like giant cells. Histopathology 46:590–592

    Article  CAS  Google Scholar 

  16. Rudloff U, Gao ZQ, Fields S et al (2005) Osteoclast-like giant cell tumor of the liver: a rare neoplasm with an aggressive clinical course. J Gastrointest Surg 9:207–214

    Article  Google Scholar 

  17. Shimizu Y, Kaneko F, Motoori T et al (2011) Undifferentiated hepatocellular carcinoma difficult to distinguish from liver abscess. Intern Med 50:519–520

    Article  Google Scholar 

  18. Matsumoto R, Yoshida K, Nakajima J et al (2012) Osteoclast-like giant cell tumor (OGCT) of the liver: report of a case [in Japanese]. Nihon Shokakibyo Gakkai Zasshi 109:255–262

    PubMed  Google Scholar 

  19. Dahm HH (2015) Immunohistochemical evaluation of a sarcomatoid hepatocellular carcinoma with osteoclast like giant cells. Diagn Pathol 10:40

    Article  Google Scholar 

  20. Chan Wah Hak C, Coyle C, Kocache A et al (2019) Emergency etoposide-cisplatin (Em-EP) for patients with germ cell tumours (GCT) and trophoblastic neoplasia (TN). BMC Cancer 19:770

    Article  Google Scholar 

  21. Bosl GJ, Yagoda A, Whitmore WF Jr et al (1984) VP-16-213 and cisplatin in the treatment of patients with refractory germ cell tumors. Am J Clin Oncol 7:327–330

    Article  CAS  Google Scholar 

  22. Peckham MJ, Barrett A, Liew KH et al (1983) The treatment of metastatic germ-cell testicular tumours with bleomycin, etoposide and cisplatin (BEP). Br J Cancer 47:613–619

    Article  CAS  Google Scholar 

  23. Janowitz T, Welsh S, Warren AY et al (2015) Prostatic elapse of an undifferentiated teratoma 24 years after orchidectomy. BMC Res Notes 8:524

    Article  Google Scholar 

  24. Arndt CA, Nascimento AG, Schroeder G et al (1998) Treatment of intermediate risk rhabdomyosarcoma and undifferentiated sarcoma with alternating cycles of vincristine/doxorubicin/cyclophosphamide and etoposide/ifosfamide. Eur J Cancer 34:1224–1229

    Article  CAS  Google Scholar 

  25. Yazawa T, Watanabe A, Araki K et al (2017) Complete resection of a huge pancreatic undifferentiated carcinoma with osteoclast-like giant cell. Int Cancer Conf J 6:193–196

    Article  Google Scholar 

  26. Singhi AD, Seethala RR, Nason K et al (2015) Undifferentiated carcinoma of the esophagus: a clinicopathological study of 16 cases. Hum Pathol 46:366–375

    Article  Google Scholar 

  27. Tajima S, Waki M, Tsuchiya T et al (2014) Granulocyte colony-stimulating factor-producing undifferentiated carcinoma of the colon mimicking a pulmonary giant cell carcinoma: a case showing overexpression of CD44 along with highly proliferating nestin-positive tumor vessels. Int J Clin Exp Pathol 7:7034–7041

    PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We gratefully acknowledge the contributions of past and present members of our division.

Author information

Authors and Affiliations

  1. Department of Surgery, Nara Medical University, 840 Shijo-Cho, Kashihara, Nara, 634-8522, Japan

    Naoki Kamitani, Takeo Nomi, Daisuke Hokuto, Takahiro Yoshikawa, Yasuko Matsuo & Masayuki Sho

Authors
  1. Naoki Kamitani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takeo Nomi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daisuke Hokuto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takahiro Yoshikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yasuko Matsuo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masayuki Sho
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

NK conducted the literature search and review, collected data, and drafted the manuscript. TN and DH proofread the manuscript. TY and YM discussed the significance of this manuscript. MS reviewed the manuscript and provided advice regarding the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Takeo Nomi.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Written informed consent for publication of their clinical details and/or clinical images was obtained from the relative of the patient.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kamitani, N., Nomi, T., Hokuto, D. et al. Primary undifferentiated carcinoma with osteoclast-like giant cells in liver and rapidly developing multiple metastases after curative hepatectomy: a case report. Int Canc Conf J 9, 244–248 (2020). https://doi.org/10.1007/s13691-020-00436-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13691-020-00436-0

Keywords

Search

Navigation