Abstract
A 75-year-old man was admitted to our hospital for treatment of esophageal cancer (EC) in March 2017. Esophagogastroduodenoscopy revealed Barrett’s esophagus and superficial, distal EC (type 0-IIc). Tumor biopsy showed esophageal adenocarcinoma. Computed tomography revealed no lymph node metastasis but did reveal a 19-mm tumor on the right side of the urinary bladder. Bladder cancer (BC) was also suspected, and the patient underwent endoscopic submucosal dissection for EC and transurethral resection of the bladder tumor. The pathological diagnosis of EC was moderately to poorly differentiated adenocarcinoma (tub2), pT1b (SM), ly0, v0. The pathological horizontal margin was negative and the vertical margin was positive. Additional esophagectomy and lymph node dissection were indicated for curability. Esophagectomy was difficult because the patient had severe cardiovascular disease, so follow-up observation was adopted. BC was classified as urothelial carcinoma Ta, ly0, v0. After 32 months, multiple tumors were found in the bladder, and BC recurrence was suspected. Transurethral resection of the bladder was performed again for seven tumors, and pathological diagnosis was poorly differentiated adenocarcinoma (tub2). The immunohistochemical features matched those of EC. We diagnosed EC metastasis in the urinary bladder. Bladder adenocarcinoma is difficult to distinguish from metastasis from other organs, especially the upper gastrointestinal tract, and cytomorphological features and appropriate clinical history are required.
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References
Napier K, Scheerer M, Misra S (2014) Esophagus cancer: a review of epidemiology, pathologenesis, staging work up and treatment modalities. World Gastrointest Oncol 6(5):112–120. https://doi.org/10.4251/wjgo.v6.i5.112
Pohl H, Sirovich B, Welch HG (2010) Are we reaching the peak? Cancer Epidemiol Biomark Prev 19(6):1468–1470. https://doi.org/10.1158/1055-9965.EPI-10-0012
Maller J, Karki N, Sapkota B, Niazi M, Remy P (2016) Rare presentation of gastroesophageal carcinoma with rectal metastasis; a case report. Am J Case Rep 17:611–615. https://doi.org/10.12659/AJCR.898534
Velcheti V, Govindan R (2007) Metastatic cancer involving bladder; a review. Can J Urol 14(1):3443–3448
Mandard AM, Chasle J, Marnay J (1981) Autopsy findings in 111 cases of esophageal cancer. Cancer 48:329–335
Raitane MP et al (1993) Diagnostic and therapeutic aspects of adenocarcinoma of urinary bladder. Ann Chir Gynaecol 206:20–27
Torenbeek R et al (1998) Value of a panel of antibodies to identify the primary origin of adenocarcinomas presenting as bladder carcinoma. Histopathology 32:20–27
Schuurman JP et al (2009) Urinary bladder metastasis from an esophageal adenocarcinoma: a case report. Am J Gastroenterol 104(6):1603–1604
Heather K, Rahoma E, Krista D, Toni P (2017) A rare case of esophageal adenocarcinoma with urinary bladder metastasis. Case Rep Gastrointest Med. https://doi.org/10.1155/2017/9343896
Werling RW et al (2003) CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol 27(3):303–310
Bardales RH et al (1998) Urine cytology of primary and secondary urinary bladder adenocarcinoma. Cancer 84(6):335–343
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Study conception: YK. Data collection: YM, YK, ST. Writing: ST. Critical review and revision: YK, EO. Final approval of the article: All Authors. Accountability for all aspects of the work: All Authors.
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Toyota, S., Kimura, Y., Fujimoto, Y. et al. A rare case of esophageal adenocarcinoma with urinary bladder metastasis. Int Canc Conf J 9, 231–234 (2020). https://doi.org/10.1007/s13691-020-00434-2
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DOI: https://doi.org/10.1007/s13691-020-00434-2