Skip to main content

Advertisement

SpringerLink
Log in

Successful treatment of advanced gastric cancer with liver metastasis by S-1 + CDDP and S-1 therapy without surgery

  • Case report
  • Published:
International Cancer Conference Journal Aims and scope Submit manuscript

Abstract

It is generally reported that prognosis of patients who have unresectable gastric cancer is from 3 to 5 months with best supportive care. Despite the improvement of survival after the appearance of S-1, the outcome of treatment for advanced gastric cancer is still unfavorable. Here we present a valuable case of advanced gastric cancer with synchronous liver metastasis, which was treated by S-1 + CDDP and S-1 therapy without surgery. A 58-year-old man was referred to our hospital with a diagnosis of advanced gastric cancer with liver metastasis at stage of cT3N0M1. He underwent first-line chemotherapy consisting of S-1 plus cispatin. 3 months later, a follow-up endoscopy revealed complete response (CR) of the gastric lesion. 3 months later, computed tomography (CT) also demonstrated disappearance of liver metastasis. Then he underwent maintenance chemotherapy with S-1 alone for 8 months. To date, there has been no recurrence for 6 years and 6 months since the acquisition of CR.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. http://www.who.int/mediacentre/factsheets/fs297/en/

  2. Koizumi W, Narahara H, Hara T et al (2008) S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol 9:215–221

    Article  CAS  Google Scholar 

  3. Japanese Gastric Cancer Assosciation (2011) Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer 14:113–123

    Article  Google Scholar 

  4. Bang YJ, Van Cutsem E, Feyereislova A et al (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 376:687–697

    Article  CAS  Google Scholar 

  5. Japanese Gastric Cancer Association (2018) Japanese gastric cancer treatment guidelines (ver. 5) (in Japanese)

  6. Kodera Y, Fujitani K, Fukushima N et al (2014) Surgical resection of hepatic metastasis from gastric cancer: a review and new recommendation in the Japanese gastric cancer treatment guidelines. Gastric Cancer 17:206–212

    Article  PubMed  Google Scholar 

  7. Koga R, Yamamoto J, Ohyama S et al (2007) Liver resection for metastatic gastric cancer: experience with 42 patients including eight long-term survivors. Jpn J Clin Oncol 37:836–842

    Article  PubMed  Google Scholar 

  8. Masuishi T, Sakai Y, Soma T et al (2012) A case of advanced gastric cancer with multiple liver metastases. Jpn J Cancer Chemother 39:975–977 (in Japanese)

    Google Scholar 

  9. Kitahara H, Oki E, Saeki H et al (2013) A case of liver metastasis from gastric cancer responding completely to S-1/docetaxel chemotherapy. Jpn J Cancer Chemother 40:1093–1097 (in Japanese)

    Google Scholar 

  10. Nakada S, Kawamoto J, Yoichi T et al (2015) A case report—a synchronous liver metastasis from gastric cancer treated with chemotherapy. Jpn J Cancer Chemother 42:1992–1994 (in Japanese)

    CAS  Google Scholar 

Download references

Funding

Katsuhiko Yanaga received a research grant from Pfizer Japan Inc (Tokyo, Japan) and Taiho Pharmaceutical Co Ltd (Tokyo, Japan).

Author information

Authors and Affiliations

  1. Department of Surgery, The Jikei University Daisan Hospital, Tokyo, Japan

    Yuichiro Tanishima, Yuya Nyumura, Tomoko Nakayoshi & Tomoyoshi Okamoto

  2. Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan

    Yuichiro Tanishima, Yuya Nyumura, Tomoko Nakayoshi, Yoshiyuki Hoya, Tomoyoshi Okamoto & Katsuhiko Yanaga

Authors
  1. Yuichiro Tanishima
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yuya Nyumura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tomoko Nakayoshi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshiyuki Hoya
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tomoyoshi Okamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Katsuhiko Yanaga
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yuichiro Tanishima.

Ethics declarations

Conflict of interest

The other authors have declared no conflict of interest.

Research involving human participants and/or animals

For this type of study, formal consent is not required.

Informed consent

Informed consent was obtained from the patient included in this report.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tanishima, Y., Nyumura, Y., Nakayoshi, T. et al. Successful treatment of advanced gastric cancer with liver metastasis by S-1 + CDDP and S-1 therapy without surgery. Int Canc Conf J 8, 101–104 (2019). https://doi.org/10.1007/s13691-019-00363-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13691-019-00363-9

Keywords

Search

Navigation