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Progression to bone-marrow carcinomatosis and extraosseous legion during treatment with radium-223 for multiple bone metastases

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Abstract

A 67-year-old man with metastatic prostate cancer presented with progression to castration-resistant prostate cancer. After sequential therapies with flutamide, estramustine phosphate, docetaxel, enzalutamide, and cabazitaxel for castration-resistant prostate cancer, radium-223 was initiated and continued up to 4 cycles. However, concurrently with radiological and clinical progressions, pancytopenia was observed due to bone-marrow carcinomatosis by prostatic adenocarcinoma. This case suggested that radium-223 should be employed at appropriated timing before appearances of extraosseous and bone-marrow lesions in addition to visceral metastasis.

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Authors and Affiliations

  1. Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Takahiko Hajime, Masaki Shiota, Tatsuro Abe, Ario Takeuchi, Junichi Inokuchi, Katsunori Tatsugami & Masatoshi Eto

  2. Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Tatsuro Abe & Yoshinao Oda

  3. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Shingo Baba & Hiroshi Honda

Authors
  1. Takahiko Hajime
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  2. Masaki Shiota
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  3. Tatsuro Abe
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  4. Ario Takeuchi
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  5. Shingo Baba
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  6. Junichi Inokuchi
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  7. Katsunori Tatsugami
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  8. Yoshinao Oda
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  9. Hiroshi Honda
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  10. Masatoshi Eto
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Corresponding author

Correspondence to Masaki Shiota.

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All authors declare no potential conflict of interest to disclose.

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Cite this article

Hajime, T., Shiota, M., Abe, T. et al. Progression to bone-marrow carcinomatosis and extraosseous legion during treatment with radium-223 for multiple bone metastases. Int Canc Conf J 7, 48–51 (2018). https://doi.org/10.1007/s13691-017-0316-8

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  • DOI: https://doi.org/10.1007/s13691-017-0316-8

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