Abstract
A 78-year-old Japanese male was referred to our hospital with a 3-month history of anorexia and right abdominal pain. A colonoscopy showed circumferential narrowing of the ascending colon with deep ulceration. Biopsy was performed, and examination of the specimen demonstrated squamous cell carcinoma. Abdominal computed tomography demonstrated thickening of the wall of the ascending colon, multiple lymph node metastases, multiple liver metastases, and peritoneal dissemination. After right hemicolectomy, histological examination demonstrated adenosquamous carcinoma. Biomarker analysis showed a microsatellite stable, wild-type KRAS gene in exon 2 and BRAF V600E mutation. Despite undergoing intensive chemotherapy, the patient died 5 months postoperatively.
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Author contributions
All authors contributed to this work. Hiroyuki Ishida prepared the description of the clinical course and wrote the manuscript; Kazuro Chiba performed biopsy; Takeru Iijima performed genetic analysis; Shin-ichiro Horiguchi performed histological diagnosis; and Tatsuro Yamaguchi performed surgery, designed the study and wrote the manuscript.
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This case report was conducted in accordance with the Ethical Guidelines for Medical and Health Research Involving Human Subjects.
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Ishida, H., Yamaguchi, T., Chiba, K. et al. A case report of ascending colon adenosquamous carcinoma with BRAF V600E mutation. Int Canc Conf J 6, 93–97 (2017). https://doi.org/10.1007/s13691-017-0283-0
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DOI: https://doi.org/10.1007/s13691-017-0283-0