Concurrent high-grade serous carcinoma and borderline tumor demonstrating different chemo-sensitivity
- 59 Downloads
Ovarian high-grade serous adenocarcinoma responds well to regular platinum/taxane chemotherapy, while borderline tumor survives and demonstrates persistent disease. A 69-year-old Japanese woman was suspected for having advanced ovarian carcinoma. MRI showed cystic tumor containing solid component of the right adnexal region with massive ascites and peritoneal dissemination. Serum CA125 was elevated to 203 µ/ml; however, no remote metastases were detected. Laparotomy revealed that peritoneal carcinomatosis spreads out to omentum and subphrenic area. Omentum was partially removed with big tumor nodules that histologically demonstrated the high-grade serous adenocarcinoma with positive ascites cytology. After 6 cycles of postoperative chemotherapy with docetaxel and carboplatin, she received second surgery where the known residual bilateral adnexa and all of the persistent tumors were perfectly resected. Pathological examination of the tumor revealed serous borderline tumor with microinvasion and no evidence of residual high-grade serous carcinoma with negative ascites cytology. This is the extremely rare case of concurrent high-grade serous carcinoma and borderline tumor demonstrating differential chemo-sensitivity.
KeywordsHigh-grade serous carcinoma Serous borderline tumor Chemo-sensitivity
Authors would like to thank English Lectures Paul Raine, Jikei University School of Medicine for their comments in English.
Compliance with ethical standards
Conflict of interest
The authors report no conflicts of interest.
This patient has already died of disease more than a year ago. At this moment, we could not keep track of the patient’s guardian or next of kin and the written consent could not be available. In the report described here, all personal details of the patient were removed from the case report to ensure that the patient cannot be identified.
- 1.Gilks CB (2004) Subclassification of ovarian surface epithelial tumors based on correlation of histologic and molecular pathologic data. Int J Gynecol Pathol 23:200–205.Google Scholar
- 3.Russell HE, McCluggage WG (2004) A multistep model for ovarian tumorigenesis: the value of mutation analysis in the KRAS and BRAF genes. J Pathol 203:617–619Google Scholar
- 4.Shih IeM, Kurman RJ (2004) Ovarian tumorigenesis. A proposed model based on morphological and molecular genetic analysis. Am J Pathol 164:1511–1518Google Scholar
- 10.Clinton B, Glenn McCluggage W (2012) Low grade ovarian serous neoplasms (low-grade serous carcinoma and serous borderline tumor) associated with high-grade serous carcinoma or undifferentiated carcinoma: report of a series of cases of an unusual phenomenon. Am J Surg Pathol 36:368–375CrossRefPubMedGoogle Scholar