Skip to main content

Advertisement

Log in

Clinical Assessment and Treatment of Early-Onset Severe Obesity

  • Childhood Obesity (A Kelly and C Fox, Section Editor)
  • Published:
Current Obesity Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This review describes clinical management of early-onset severe obesity, defined here as severe obesity in children ≤ 5 years old. It summarizes current information regarding (1) assessment, specifically growth, genetics, cardiometabolic risk, health behaviors, developmental considerations, and psychosocial factors, and (2) treatment, focusing on lifestyle modification including parent training and a brief summary of pharmacotherapy.

Recent Findings

Prevalence of severe obesity in young children has remained stable yet most of these children will become adults with obesity. Interventions that address multiple health domains, such as eating habits, physical activity, and parenting skills, are necessary for addressing early-onset severe obesity. Research into pharmacotherapy remains limited but may provide future strategies for management.

Summary

Early-onset severe obesity significantly influences children’s long-term health and management should focus on intervention to promote BMI reduction. Further research into effective strategies is necessary to address the needs of this high-risk population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Ogden CL, Carroll MD, Fryar CD, Flegal KM. Prevalence of obesity among adults and youth: United States, 2011-2014. NCHS Data Brief. 2015(219):1–8.

  2. Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of obesity among adults and youth: United States, 2015-2016. NCHS Data Brief. 2017(288):1–8.

  3. Roy SM, Spivack JG, Faith MS, Chesi A, Mitchell JA, Kelly A, et al. Infant BMI or weight-for-length and obesity risk in early childhood. Pediatrics. 2016;137(5).

  4. Styne DM, Arslanian SA, Connor EL, Farooqi IS, Murad MH, Silverstein JH, et al. Pediatric obesity-assessment, treatment, and prevention: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2017;102(3):709–57.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Smego A, Woo JG, Klein J, Suh C, Bansal D, Bliss S, et al. High body mass index in infancy may predict severe obesity in early childhood. J Pediatr. 2017;183:87–93.e1.

    Article  PubMed  Google Scholar 

  6. Kelly AS, Barlow SE, Rao G, Inge TH, Hayman LL, Steinberger J, et al. Severe obesity in children and adolescents: identification, associated health risks, and treatment approaches: a scientific statement from the American Heart Association. Circulation. 2013;128(15):1689–712.

    Article  PubMed  Google Scholar 

  7. Flegal KM, Wei R, Ogden CL, Freedman DS, Johnson CL, Curtin LR. Characterizing extreme values of body mass index-for-age by using the 2000 Centers for Disease Control and Prevention growth charts. Am J Clin Nutr. 2009;90(5):1314–20.

    Article  CAS  PubMed  Google Scholar 

  8. Freedman DS, Butte NF, Taveras EM, Goodman AB, Blanck HM. Longitudinal changes in BMI z-scores among 45 414 2-4-year olds with severe obesity. Ann Hum Biol. 2017;44(8):687–92.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Freedman DS, Butte NF, Taveras EM, Goodman AB, Ogden CL, Blanck HM. The limitations of transforming very high body mass indexes into z-scores among 8.7 million 2- to 4-year-old children. J Pediatr. 2017;188:50–6.e1.

    Article  PubMed  PubMed Central  Google Scholar 

  10. • Tester JM, Phan TT, Tucker JM, Leung CW, Dreyer Gillette ML, Sweeney BR, et al. Characteristics of children 2 to 5 years of age with severe obesity. Pediatrics. 2018;141(3). Using NHANES data, the authors describe characterisitcs seen in 2–5-year olds with severe obesity.

  11. Ball GDC, Savu A, Kaul P. Changes in the prevalence of overweight, obesity, and severe obesity between 2010 and 2017 in preschoolers: a population-based study. Pediatr Obes. 2019;14(11):e12561.

    Article  PubMed  Google Scholar 

  12. Ogden CL, Carroll MD, Lawman HG, Fryar CD, Kruszon-Moran D, Kit BK, et al. Trends in obesity prevalence among children and adolescents in the United States, 1988-1994 through 2013-2014. JAMA. 2016;315(21):2292–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Skinner AC, Ravanbakht SN, Skelton JA, Perrin EM, Armstrong SC. Prevalence of obesity and severe obesity in US children, 1999–2016. Pediatrics. 2018;141(3).

  14. Ford MC, Gordon NP, Howell A, Green CE, Greenspan LC, Chandra M, et al. Obesity severity, dietary behaviors, and lifestyle risks vary by race/ethnicity and age in a northern California cohort of children with obesity. J Obes. 2016;2016:4287976.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Fox CK, Gross AC, Bomberg EM, Ryder JR, Oberle MM, Bramante CT, et al. Severe obesity in the pediatric population: current concepts in clinical care. Curr Obes Rep. 2019;8(3):201–9.

    Article  PubMed  Google Scholar 

  16. •• Ward ZJ, Long MW, Resch SC, Giles CM, Cradock AL, Gortmaker SL. Simulation of growth trajectories of childhood obesity into adulthood. N Engl J Med. 2017;377(22):2145–53 This article indicates the strong tracking of obesity over the lifespan. If severely obese at age 2, there is only a 21% chance of not having obesity as an adult. If severely obese at age 5, this decreases to a 10% chance of not having obesity as an adult.

    Article  PubMed  Google Scholar 

  17. Brady CC, Thaker VV, Lingren T, Woo JG, Kennebeck SS, Namjou-Khales B, et al. Suboptimal clinical documentation in young children with severe obesity at tertiary care centers. Int J Pediatr. 2016;2016:4068582.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Huvenne H, Dubern B, Clément K, Poitou C. Rare genetic forms of obesity: clinical approach and current treatments in 2016. Obes Facts. 2016;9(3):158–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. da Fonseca ACP, Mastronardi C, Johar A, Arcos-Burgos M, Paz-Filho G. Genetics of non-syndromic childhood obesity and the use of high-throughput DNA sequencing technologies. J Diabetes Complicat. 2017;31(10):1549–61.

    Article  Google Scholar 

  20. Fairbrother U, Kidd E, Malagamuwa T, Walley A. Genetics of severe obesity. Current Diabetes Reports. 2018;18(10):85.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O’Rahilly S. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med. 2003;348(12):1085–95.

    Article  CAS  PubMed  Google Scholar 

  22. Santoro N, Cirillo G, Xiang Z, Tanas R, Greggio N, Morino G, et al. Prevalence of pathogenetic MC4R mutations in Italian children with early onset obesity, tall stature and familial history of obesity. BMC Med Genet. 2009;10:25.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Stanikova D, Surova M, Ticha L, Petrasova M, Virgova D, Huckova M, et al. Melanocortin-4 receptor gene mutations in obese Slovak children. Physiol Res. 2015;64(6):883–90.

    Article  CAS  PubMed  Google Scholar 

  24. Vollbach H, Brandt S, Lahr G, Denzer C, von Schnurbein J, Debatin KM, et al. Prevalence and phenotypic characterization of MC4R variants in a large pediatric cohort. Int J Obes. 2017;41(1):13–22.

    Article  CAS  Google Scholar 

  25. De Rosa MC, Chesi A, McCormack S, Zhou J, Weaver B, McDonald M, et al. Characterization of rare variants in MC4R in African American and Latino children with severe early-onset obesity. J Clin Endocrinol Metab. 2019;104(7):2961–70.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Farooqi IS, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh JM, et al. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med. 2007;356(3):237–47.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Kohlsdorf K, Nunziata A, Funcke JB, Brandt S, von Schnurbein J, Vollbach H, et al. Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency. Int J Obes. 2018;42(9):1602–9.

    Article  CAS  Google Scholar 

  28. Gowda S, Seibert T, Uli N, Farrell R. Pediatric obesity: endocrinologic and genetic etiologies and management. Current Cardiovascular Risk Reports. 2019;13(12):1–11.

    Article  Google Scholar 

  29. Bocca G, Ongering EC, Stolk RP, Sauer PJ. Insulin resistance and cardiovascular risk factors in 3- to 5-year-old overweight or obese children. Horm Res Paediatr. 2013;80(3):201–6.

    Article  CAS  PubMed  Google Scholar 

  30. Shashaj B, Bedogni G, Graziani MP, Tozzi AE, DiCorpo ML, Morano D, et al. Origin of cardiovascular risk in overweight preschool children: a cohort study of cardiometabolic risk factors at the onset of obesity. JAMA Pediatr. 2014;168(10):917–24.

    Article  PubMed  Google Scholar 

  31. Baughcum AE, Gramling K, Eneli I. Severely obese preschoolers in a tertiary care obesity program: characteristics and management. Clin Pediatr (Phila). 2015;54(4):346–52.

    Article  Google Scholar 

  32. Carsley SE, Anderson LN, Plumptre L, Parkin PC, Maguire JL, Birken CS. Severe obesity, obesity, and cardiometabolic risk in children 0 to 6 years of age. Child Obes. 2017;13(5):415–24.

    Article  PubMed  Google Scholar 

  33. Wickel EE, Ali L, Hawkins H, Hemming E. Results of a referral-based weight management program targeted toward children aged 2 to 6 years with obesity or severe obesity. BMC Pediatr. 2019;19(1):504.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Gaffka BJ, Hassink SG, Santos M, Eneli I. Provider observations of youth with early onset severe obesity in tertiary care obesity programs. Child Obes. 2018;14(7):477–83.

    Article  PubMed  Google Scholar 

  35. Gross AC, Fox CK, Rudser KD, Foy AMH, Kelly AS. Eating behaviours are different in youth with obesity and severe obesity. Clinical Obesity. 2016;6(1):68–72.

    Article  CAS  PubMed  Google Scholar 

  36. Khalsa AS, Kharofa R, Ollberding NJ, Bishop L, Copeland KA. Attainment of ‘5-2-1-0’ obesity recommendations in preschool-aged children. Prev Med Rep. 2017;8:79–87.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Miller AL, Kaciroti N, Lebourgeois MK, Chen YP, Sturza J, Lumeng JC. Sleep timing moderates the concurrent sleep duration–body mass index association in low-income preschool-age children. Acad Pediatr. 2014;14(2):207–13.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Tsao-Wu M, Williams RJ, Hendy HM, Novick MB. Associations between obesity severity and medical comorbidities for children with obesity in low intensity hospital intervention. Obes Res Clin Pract. 2019;13(6):555–60.

    Article  PubMed  Google Scholar 

  39. Wentz E, Björk A, Dahlgren J. Neurodevelopmental disorders are highly over-represented in children with obesity: a cross-sectional study. Obesity. 2017;25(1):178–84.

    Article  PubMed  Google Scholar 

  40. Cataldo R, Huang J, Calixte R, Wong AT, Bianchi-Hayes J, Pati S. Effects of overweight and obesity on motor and mental development in infants and toddlers. Pediatr Obes. 2016;11(5):389–96.

    Article  CAS  PubMed  Google Scholar 

  41. Cheng J, East P, Blanco E, Sim EK, Castillo M, Lozoff B, et al. Obesity leads to declines in motor skills across childhood. Child Care Health Dev. 2016;42(3):343–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Chen K-C, Tung L-C, Tung C-H, Yeh C-J, Yang J-F, Wang C-H. An investigation of the factors affecting flatfoot in children with delayed motor development. Res Dev Disabil. 2014;35(3):639–45.

    Article  PubMed  Google Scholar 

  43. Hughes S, Frazier-Wood A. Satiety and the self-regulation of food take in children: a potential role for gene-environment interplay. Curr Obes Rep. 2016;5(1):81–7.

    Article  PubMed  PubMed Central  Google Scholar 

  44. •• Wood AC, Blissett JM, Brunstrom JM, Carnell S, Faith MS, Fisher JO, et al. Caregiver influences on eating behaviors in young children: a scientific statement from the American Heart Association. Journal of the American Heart Association. 2020;9(10):e014520 This scientific statement reviews the genetic and environmental influences on young children’s eating behaviors. The authors outline research relevant to infancy, toddlerhood, and preschool as well as provide suggestions for working with caregivers of young children.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Speirs K, Fiese B. The relationship between food insecurity and BMI for preschool children. Matern Child Health J. 2016;20(4):925–33.

    Article  PubMed  Google Scholar 

  46. Falbe J, Cadiz AA, Tantoco NK, Thompson HR, Madsen KA. Active and healthy families: a randomized controlled trial of a culturally tailored obesity intervention for Latino children. Acad Pediatr. 2015;15(4):386–95.

    Article  PubMed  Google Scholar 

  47. Camfferman R, Jansen PW, Rippe RCA, Mesman J, Derks IPM, Tiemeier H, et al. The association between overweight and internalizing and externalizing behavior in early childhood. Soc Sci Med. 2016;168:35–42.

    Article  PubMed  Google Scholar 

  48. Garthus-Niegel S, Hagtvet KA, Vollrath ME. A prospective study of weight development and behavior problems in toddlers: the Norwegian Mother and Child Cohort Study. 2010;10(1).

  49. Christison AL, Vaidya S, Tinajero-Deck L, Hampl SE. Application of the medical neighborhood to children with severe obesity. Child Obes. 2018;14(7):461–7.

    Article  PubMed  Google Scholar 

  50. Foster BA, Farragher J, Parker P, Sosa ET. Treatment interventions for early childhood obesity: a systematic review. Acad Pediatr. 2015;15(4):353–61.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Force USPST, Grossman DC, Bibbins-Domingo K, Curry SJ, Barry MJ, Davidson KW, et al. Screening for obesity in children and adolescents: US Preventive Services Task Force recommendation statement. JAMA. 2017;317(23):2417–26.

    Article  Google Scholar 

  52. Ek A, Chamberlain KL, Sorjonen K, Hammar U, Malek ME, Sandvik P, et al. A parent treatment program for preschoolers with obesity: a randomized controlled trial.(Report). Pediatrics. 2019;144(2).

  53. Kairey L, Matvienko-Sikar K, Kelly C, McKinley MC, O’Connor EM, Kearney PM, et al. Plating up appropriate portion sizes for children: a systematic review of parental food and beverage portioning practices. Obes Rev. 2018;19(12):1667–78.

    Article  CAS  PubMed  Google Scholar 

  54. Active start: A statement of physical activity guidelines for children from birth to age 5.

  55. Carlo G, White RMB, Streit C, Knight GP, Zeiders KH. Longitudinal relations among parenting styles, prosocial behaviors, and academic outcomes in U.S. Mexican adolescents. Child Dev. 2018;89(2):577–92.

    Article  PubMed  Google Scholar 

  56. Shafi RMA, Bieber ED, Shekunov J, Croarkin PE, Romanowicz M. Evidence based dyadic therapies for 0- to 5-year-old children with emotional and behavioral difficulties. Frontiers in Psychiatry. 2019;10.

  57. Kühnen P, Clément K, Wiegand S, Blankenstein O, Gottesdiener K, Martini LL, et al. Proopiomelanocortin deficiency treated with a melanocortin-4 receptor agonist. N Engl J Med. 2016;375(3):240–6.

    Article  PubMed  Google Scholar 

  58. Collet TH, Dubern B, Mokrosinski J, Connors H, Keogh JM, Mendes de Oliveira E, et al. Evaluation of a melanocortin-4 receptor (MC4R) agonist (setmelanotide) in MC4R deficiency. Mol Metab. 2017;6(10):1321–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Clement K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, et al. MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency. Nat Med. 2018;24(5):551–5.

    Article  CAS  PubMed  Google Scholar 

  60. • Brandt S, von Schnurbein J, Lennerz B, Kohlsdorf K, Vollbach H, Denzer C, et al. Methylphenidate in children with monogenic obesity due to LEPR or MC4R deficiency improves feeling of satiety and reduces BMI-SDS-A case series. Pediatr Obes. 2020;15(1):e12577 This paper looks specifically at use of methylphenidate in children to treat monogenic obesity. Unlike many other trials, it includes two participants < 5 years of age, making it especially relevant to this topic.

    Article  PubMed  Google Scholar 

  61. Fox CK, Marlatt KL, Rudser KD, Kelly AS. Topiramate for weight reduction in adolescents with severe obesity. Clin Pediatr (Phila). 2015;54(1):19–24.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amy C. Gross.

Ethics declarations

Conflict of Interest

The authors have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Childhood Obesity

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Raatz, S., Gross, A.C. Clinical Assessment and Treatment of Early-Onset Severe Obesity. Curr Obes Rep 10, 31–38 (2021). https://doi.org/10.1007/s13679-020-00418-6

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13679-020-00418-6

Keywords

Navigation