Spontaneous Physical Activity Defends Against Obesity
Purpose of Review
Spontaneous physical activity (SPA) is a physical activity not motivated by a rewarding goal, such as that associated with food-seeking or wheel-running behavior. SPA is often thought of as only “fidgeting,” but that is a mischaracterization, since fidgety behavior can be linked to stereotypies in neurodegenerative disease and other movement disorders. Instead, SPA should be thought of as all physical activity behavior that emanates from an unconscious drive for movement.
An example of this may be restless behavior, which can include fidgeting and gesticulating, frequent sit-to-stand movement, and more time spent standing and moving. All physical activity burns calories, and as such, SPA could be manipulated as a means to burn calories, and defend against weight gain and reduce excess adiposity.
In this review, we discuss human and animal literature on the use of SPA in reducing weight gain, the neuromodulators that could be targeted to this end, and future directions in this field.
KeywordsSpontaneous physical activity Non-exercise energy expenditure Locomotion Exercise Obesity Food intake Eating behavior Brain Central nervous system Orexin Dynorphin DREADD Optogenetics Human Animal
Compliance with Ethical Standards
Conflict of Interest
Catherine M. Kotz declares that she has no conflict of interest.
Claudio E. Perez-Leighton declares that he has no conflict of interest.
Jennifer A. Teske declares that she has no conflict of interest.
Charles J. Billington has received compensation from Novo Nordisk, EnteroMedics, and Optum Health for service as a consultant.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors. All studies (Fig. 1) and those cited by the authors in this review had local Institutional Animal Care and Use Committee approval.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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