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Maintaining Weight Loss: an Ongoing Challenge

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  1. Anderson J, Konz E, Frederich R, Wood C. Long-term weight-loss maintenance: a meta-analysis of US studies. Am J Clin Nutr. 2001;74:579–84.

    CAS  PubMed  Google Scholar 

  2. Fothergill E, Guo J, Howard L, et al. Persistent metabolic adaptation 6 years after “The Biggest Loser” competition. Obesity. 2016;24:1612–9.

    Article  PubMed  Google Scholar 

  3. Johannsen D, Knuth N, Huizenga R, et al. Metabolic slowing with massive weight loss despite preservation of fat-free mass. J Clin Endocrinol Metab. 2012;97:2489–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Leibel R, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med. 1995;332:6218.

    Article  Google Scholar 

  5. Rosenbaum M, Hirsch J, Gallagher D, Leibel R. Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr. 2008;88:906–12.

    CAS  PubMed  Google Scholar 

  6. Rosenbaum M, Leibel R. Models of energy homeostasis in response to maintenance of reduced body weight. Obesity. 2016;24:1620–9.

    Article  PubMed  Google Scholar 

  7. Sumithran P, Prendergast L, Delbridge E, et al. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011;365:1597–604.

    Article  CAS  PubMed  Google Scholar 

  8. Chearskul S, Delbridge E, Shulkes A, et al. Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations. Am J Clin Nutr. 2008;87:1238–46.

    CAS  PubMed  Google Scholar 

  9. Cummings D, Weigle D, Frayo R, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med. 2002;346:1623–30.

    Article  PubMed  Google Scholar 

  10. Pfluger P, Kampe J, Castaneda T, et al. Effect of human body weight changes on circulating levels of peptide YY and peptide YY3–36. J Clin Endocrinol Metab. 2007;92:583–8.

    Article  CAS  PubMed  Google Scholar 

  11. Rosenbaum M, Goldsmith R, Bloomfield D, et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest. 2005;115:3579–86.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Doucet E, Imbeault P, St-Pierre S, et al. Appetite after weight loss by energy restriction and a low-fat diet-exercise follow-up. Int J Obes Relat Metab Disord. 2000;24:906–14.

    Article  CAS  PubMed  Google Scholar 

  13. Cameron J, Goldfield G, Cyr M-J, Doucet E. The effects of prolonged caloric restriction leading to weight-loss on food hedonics and reinforcement. Physiol Behav. 2008;94:474–80.

    Article  CAS  PubMed  Google Scholar 

  14. Drewnowski A, Brunzell J, Sande K, et al. Sweet tooth reconsidered: taste responsiveness in human obesity. Physiol Behav. 1985;35:617–22.

    Article  CAS  PubMed  Google Scholar 

  15. Rosenbaum M, Sy M, Pavlovich K, et al. Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest. 2008;118:2583–91.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Purcell K, Sumithran P, Prendergast L, et al. The effect of rate of weight loss on long-term weight management: a randomised controlled trial. Lancet Diabetes Endocrinol. 2014;2:954–62.

    Article  PubMed  Google Scholar 

  17. Vink R, Roumans N, Arkenbosch L, et al. The effect of rate of weight loss on long-term weight regain in adults with overweight and obesity. Obesity. 2016;24:321–7.

    Article  CAS  PubMed  Google Scholar 

  18. Jensen M, Ryan D, Apovian C, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation. 2014;129(25 Suppl 2):S102–138.

    Article  PubMed  Google Scholar 

  19. Wyatt H, Phelan S, Wing R, Hill J. Lessons from patients who have successfully maintained weight loss. Obes Manag. 2005;1:56–61.

    Article  Google Scholar 

  20. Apovian C, Aronne L, Bessesen D, et al. Pharmacological management of obesity: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100:342–62.

    Article  CAS  PubMed  Google Scholar 

  21. Peterli R, Steinert R, Woelnerhanssen B, et al. Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a randomized, prospective trial. Obes Surg. 2012;22:740–8.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Priya Sumithran.

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Conflict of Interest

Priya Sumithran has received speaker honoraria from Nestlé and Novo Nordisk.

Joseph Proietto is chair of the Medical Advisory Board for Saxenda (Australia, Novo Nordisk) and has received speaker honoraria from iNova and Nestlé.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Sumithran, P., Proietto, J. Maintaining Weight Loss: an Ongoing Challenge. Curr Obes Rep 5, 383–385 (2016).

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