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Neuroendocrine Profile in the Night Eating Syndrome

  • Psychological Issues (M Hetherington and V Drapeau, Section Editors)
  • Published:
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Abstract

Night eating syndrome (NES) has recently been getting more attention as a recognized eating disorder. NES is characterized by a delay in the circadian pattern of food intake, associated with morning anorexia, evening hyperphagia, awakenings from sleep with ingestion of food, depressed mood, and obesity. Although the behavioral characteristics of NES were first described in 1955, the neuroendocrine characteristics have only been described recently. Researchers have examined several hormones that appear to differ in night eaters compared to controls, including melatonin, leptin, and cortisol. Researchers have more recently examined the hypothalamic-pituitary-adrenal axis in more detail, with emphasis on corticotrophin releasing hormone. Further studies have examined ghrelin, growth hormone, prolactin, and IGF-1, with differences observed in the circadian pattern of these hormones in those with NES compared to controls. Despite increasing interest in the neuroendocrine profile of night eating behavior, the biological basis of NES is still not well understood.

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References

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  1. Stunkard AJ, Grace WJ, Wolff HG. The night eating syndrome: a pattern of food intake among certain obese patients. Am J Med. 1955;19:78–86.

    Article  CAS  PubMed  Google Scholar 

  2. Rand CS, Macgregor AM, Stunkard AJ. The night eating syndrome in the general population and among postoperative obesity surgery patients. Int J Eat Disord. 1997;22:65–9.

    Article  CAS  PubMed  Google Scholar 

  3. Stunkard A, Berkowitz R, Wadden T, Tanrikut C, Reiss E, Young L. Binge eating disorder and the night eating syndrome. Int J Obes Relat Metab Disord. 1996;20:1–6.

    CAS  PubMed  Google Scholar 

  4. Stunkard AJ. Eating patterns and obesity. Psychiatr Q. 1959;33:284–95.

    Article  CAS  PubMed  Google Scholar 

  5. Rand CS, Kuldau JM. Morbid obesity: a comparison between a general population and obesity surgery patients. Int J Obes Relat Metab Disord. 1993;17:657–61.

    CAS  PubMed  Google Scholar 

  6. Tamai H, Matsubayashi S, Kiyohara K, Nakagawa T, Okimura MC, Walter Jr RM, et al. Hypothalamic-pituitary-Thyroidal Dysfunctions in Anorexia Nervosa. Psychother Psychosom. 1986;46:127–31.

    Article  CAS  PubMed  Google Scholar 

  7. Hajak G, Rodenbeck A, Staedt J, Bandelow B, Huether G, Ruther E. Nocturnal plasma melatonin levels in patients suffering from chronic primary insomnia. J Pineal Res. 1995;19:116–22.

    Article  CAS  PubMed  Google Scholar 

  8. Kennedy SH, Garfinkel PE, Parienti V, Costa D, Brown GM. Changes in melatonin levels but not cortisol levels are associated with depression in patients with eating disorders. Arch Gen Psychiatry. 1989;46:73–8.

    Article  CAS  PubMed  Google Scholar 

  9. Kuratsune H, Yamaguti K, Sawada M, Kodate S, Machii T, Kanakura Y, et al. Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome. Int J Mol Med. 1998;1:143–6.

    CAS  PubMed  Google Scholar 

  10. Hudson JI, Pope HG, Jonas JM, Laffer PS, Hudson MS, Melby JC. Hypothalamic-pituitary-adrenal axis hyperactivity in bulimia. Psychiatry Res. 1983;8:111–7.

    Article  CAS  PubMed  Google Scholar 

  11. Birketvedt GS, Drivenes E, Agledahl I, Sundsfjord J, Olstad R, Florholmen JR. Bulimia nervosa- a primary defect in the hypothalamic-pituitary-adrenal axis? Appetite. 2006;46(2):164–7.

    Article  CAS  PubMed  Google Scholar 

  12. Raber J. Detrimental effects of chronic hypothalamic-pituitary-adrenal axis activation. From obesity to memory deficits. Molneurobiol. 1998;18:1–22.

    Article  CAS  Google Scholar 

  13. Birkevedt GS, Florholmen J, Sundsfjord J, Dinges D, Østerud B, Stunkard A. Behavioral and neuroendocrine characteristics of the night eating syndrome. JAMA. 1999;282:655–63.

    Google Scholar 

  14. Van Cauter E, Sturis J, Byrne MM, et al. Demonstration of rapid light-induced advances and delays of the human circadian clock using hormonal phase marker. Am J Physiol. 1994;266:E953–63.

    PubMed  Google Scholar 

  15. Spat-Schwalbe E, Scholler T. kern W, fehm HL, Born J. Nocturnal adrenocorticotropin and cortisol secretion depends on sleep duration and decreases in association with spontaneous awakening in the morning. J Endocrinol Metab. 1992;75:1431–5.

    Google Scholar 

  16. Hofman RA, Swaab DF. Diurnal and seasonal rhtythms of neuronal activity in the suprasciasmatic nucleus in humans. J Biol Rhythms. 1993;8:283–95.

    Article  CAS  PubMed  Google Scholar 

  17. Birketvedt GS, Sundsfjord J, Florholmen JR. Hypothalamic-pituitary-adrenal axis in the night eating syndrome. Am J Physiol Endocrinol Metab. 2002;282:E366–9.

    CAS  PubMed  Google Scholar 

  18. Allison KC, Ahima RS, Reardon JPO, Dinges DF, Vibhavasu S, Cummings DE, et al. Neuroendocrine profiles Associated with Energy Intake, Sleep, and Stress in the Night Eating Syndrome. JCEM. 2005;11(90):6214–7.

    Google Scholar 

  19. Birketvedt GS, Geliebter A, Kristiansen I, Figenschau Y, Roll R, Florholmen JR. Diurnal secretion of ghrelin, growth hormone, insulin binding proteins and prolactin in normal weight and overweight subjects with and without the night eating syndrome. Appetite. 2012;59(3):688–92. This paper reviews previous studies and expands on the knowledge from previous neuroendocrine studies of NES.

    Article  CAS  PubMed  Google Scholar 

  20. Morrow J, Gluck M, Lorence M, Flacbaum L, Geliebter A. Night eating status and influence on body weight, body image, hunger, and cortisol pre- and post-Roux-en-Y gastric bypass (RYGB) surgery. Eat Weight Disord. 2008;13(4):e96–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Geliebter A, Carnell S, Gluck ME. Cortisol and ghrelin concentrations following a cold pressor stress test in overweight individuals with and without night eating. Int J Obes. 2013;37(8):1104–8. doi:10.1038/ijo.2012.166. This paper provides insight into the relationship between stress and NES.

    Article  CAS  Google Scholar 

  22. Carnell, S., Gluck, M.E., &Geliebter, A. (2013). Cortisol and ghrelin in overweight women with and without night eating: Morning and afternoon levels (submitted).

  23. Hansen T, Bratlid T, Libgjerde O, Brenn T. Midwinter insomnia in the subarctic region: Evening levels of serum melatonin and cortisol before and after treatment with bright artificial light. Acta Psychiatr Scand. 1987;75:428–34.

    Article  CAS  PubMed  Google Scholar 

  24. Fernstrom JD. Dietary effects on brain serotonin synthesis: relationship to appetite regulation. Am J Clin Nutr. 1985;42:1072–82.

    CAS  PubMed  Google Scholar 

  25. Zagajewski J, Drozdowics D, Brzozowska I, Hubalewska-Mazgaj M, Stelmaszynska T, Laidler PM, et al. Conversion L-tryptophan to melatonin in the gastrointestinal tract: the new high performance liquid chromatography method enabling simultaneous determination of six metabolites of L-tryptophan by native fluorescence and UV–VIS detection. J Physiol Pharmacol. 2012;63(6):613–21.

    CAS  PubMed  Google Scholar 

  26. Quin LQ, Li J, Wang J, Xu JY, Kaneko T. The effects of nocturnal life on endocrine circadian patterns in healthy adults. Life Sci. 2003;73:2467–75.

    Article  Google Scholar 

  27. Goel N, Stunkard AJ, Rogers NL, Van Dongen H, et al. Circadian Rhythm Profiles in Women with Night Eating Syndrome. J Biol Rhythms. 2009;24(1):85–94.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Jarkovska Z, Krsek M, Rosicka M, Marek J. Endocrine and metabolic activities of a recently isolated peptide hormone ghrelin, an endogenous ligand of the growth hormone secretagogue receptor. Endocr Regul. 2004;38(2):80–6.

    CAS  PubMed  Google Scholar 

  29. Horvath TL, Diano S, Sotonyi P, Heman M, Tschøp M. Ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology. 2001;142(10):4163–9.

    CAS  PubMed  Google Scholar 

  30. Castaneda TR, Tong J, Datta R, Culler M, Tschøp MH. Ghrelin in the regulation of body weight and metabolism. Front Neuroendocrinol. 2010;31(1):44–60.

    Article  CAS  PubMed  Google Scholar 

  31. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 2001;50(8):1714–9.

    Article  CAS  PubMed  Google Scholar 

  32. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, et al. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab. 2001;86(10):4753–8.

    Article  CAS  PubMed  Google Scholar 

  33. Tschop M, Wawarta R, Riepl RL, Friedrich S, Bidlinmaier M, Landgraf R, et al. Post-prandial decrease of circulating ghrelin levels. J Endocrinol Invest. 2001;24:RC19–21.

    CAS  PubMed  Google Scholar 

  34. Sinha MK, Ohannesian JP, Heiman ML, Kriauciunas A, Stephens TW, Magosin S, et al. Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest. 1996;1(97):1344–7.

    Article  Google Scholar 

  35. Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function, and regulation of secretion. Physiol Rev. 2000;80(4):1523–631.

    CAS  PubMed  Google Scholar 

  36. Weikel JC, Wichniak A, Ising M, Brunner H, Friess E, Held K, et al. Ghrelin promotes slow wave sleep in humans. Am J Physiol Endocrinol Metab. 2003;284(2):E407–15.

    CAS  PubMed  Google Scholar 

  37. Rosenhagen CM, Uhr M, Schussler P, Steiger A. Elevated plasma ghrelin levels in night-eating syndrome. Am J Psychiatry. 2005;162:813.

    Article  PubMed  Google Scholar 

  38. Bulent O. Yildiz, Marc A Suchard, Ma-Li Wong, Samuel M. McCann and Julio Licino. Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. 2004; 101(28).

  39. Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes. 2001;50:707–9.

    Article  PubMed  Google Scholar 

  40. Lindeman JH, Pijl H, Van Dielen FM, Lentjes EG, Van Leuven C, Kooistra T. Ghrelin and the hyposomatotropism of obesity. Obes Res. 2002;10(11):1161–6.

    Article  CAS  PubMed  Google Scholar 

  41. Yujin S, Tamotsu S, Asuka O, Hideki K, Hisayuki O, Hideki T, et al. Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. J Clin Invest. 2002;109(11):1429–36.

    Article  Google Scholar 

  42. Schüssler P, Uhr M, Ising M, Weikel JC, Schmid DA, Held K, et al. Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans. Psychoneuroendocrinology. 2006;31:915–23.

    Article  PubMed  Google Scholar 

  43. Garcia-Robles MJ, Segura-Otega JE, Fafutis-Morris M. The biology of leptin and its implications in Breast Cancer: A General View. J Interferon Cytkine Res 2013.

  44. Korbonits M, Trainer PJ, Little JA, Edwards R, Kopelman PG, Besser GM, et al. Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary-adrenal activity. Clin Endocrinol (Oxf). 1997;46(6):751–7.

    Article  CAS  Google Scholar 

  45. Allison KC, Lundgren JD, O'Reardon JP, Geliebter A, Gluck ME, Vinai P, et al. Proposed diagnostic criteria for night eating syndrome. Int J Eat Disord. 2010;43:241–7. This paper outlines the most up-to-date diagnostic criteria for NES.

    PubMed  Google Scholar 

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Grethe Støa Birketvedt, Allan Geliebter, Jon Florholmen, and Marci E. Gluck declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to Grethe Støa Birketvedt.

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Birketvedt, G.S., Geliebter, A., Florholmen, J. et al. Neuroendocrine Profile in the Night Eating Syndrome. Curr Obes Rep 3, 114–119 (2014). https://doi.org/10.1007/s13679-013-0090-7

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