Olshansky SJ, Passaro DJ, Hershow RC, Layden J, Carnes BA, Brody J, Hayflick L, Butler RN, Allison DB, Ludwig DS. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med. 2005;352:1138–45.
Yanovski SZ, Yanovski JA. Obesity prevalence in the United States—up, down, or sideways? N Engl J Med. 2011;364:987–9.
Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999–2008. JAMA. 2010;303:235–41.
Keith SW, Redden DT, Katzmarzyk PT, Boggiano MM, Hanlon EC, Benca RM, Ruden D, Pietrobelli A, Barger JL, Fontaine KR, Wang C, Aronne LJ, Wright SM, Baskin M, Dhurandhar NV, Lijoi MC, Grilo CM, DeLuca M, Westfall AO, Allison DB. Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int J Obes (Lond). 2006;30:1585–94.
McAllister EJ, Dhurandhar NV, Keith SW, Aronne LJ, Barger J, Baskin M, Benca RM, Biggio J, Boggiano MM, Eisenmann JC, Elobeid M, Fontaine KR, Gluckman P, Hanlon EC, Katzmarzyk P, Pietrobelli A, Redden DT, Ruden DM, Wang C, Waterland RA, Wright SM, Allison DB. Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr. 2009;49:868–913.
Johnson F, Mavrogianni A, Ucci M, Vidal-Puig A, Wardle J. Could increased time spent in a thermal comfort zone contribute to population increases in obesity? Obes Rev. 2011;12:543–51.
Hansen JC, Gilman AP, Odland JO. Is thermogenesis a significant causal factor in preventing the “globesity” epidemic? Med Hypotheses. 2010;75:250–6.
Weinsier RL, Bracco D, Schutz Y. Predicted effects of small decreases in energy expenditure on weight gain in adult women. Int J Obes Relat Metab Disord. 1993;17:693–700.
Katan MB, Ludwig DS. Extra calories cause weight gain—but how much? JAMA. 2010;303:65–6.
Benzinger TH. Heat regulation: homeostasis of central temperature in man. Physiol Rev. 1969;49:671–759.
Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev. 2004;84:277–359.
Chaffee RR, Roberts JC. Temperature acclimation in birds and mammals. Annu Rev Physiol. 1971;33:155–202.
Davis TR. The influence of climate on nutritional requirements. Am J Public Health Nations Health. 1964;54:2051–67.
Herrington LP. The heat regulation of small laboratory animals at various environmental temperatures. Am J Physiol. 1940;129:123–39.
Erikson H, Krog J, Andersen KL, Scholander PF. The critical temperature in naked man. Acta Physiol Scand. 1956;37:35–9.
Brobeck JR. Food intake as a mechanism of temperature regulation. Yale J Biol Med. 1948;20:545–52.
Herman CP. Effects of heat on appetite. In: Marriott BM, editor. Nutrional needs in hot environments. 1993. p. 187–214.
Yates AA. Food intake, appetite, and work in hot environments. In: Marriott BM, editor. Nutritional needs in hot environments. 1993. p. 297–304.
Keys A, Brozek J, Henschel A, Mickelsen O. The biology of human starvation. Taylor: University of Minnesota Press; 1950.
Westerterp-Plantenga MS. Effects of extreme environments on food intake in human subjects. Proc Nutr Soc. 1999;58:791–8.
Chaffee RR, Kaufman WC, Kratochvil CH, Sorenson MW, Conaway CH, Middleton CC. Comparative chemical thermoregulation in cold- and heat-acclimated rodents, insectivores, protoprimates, and primates. Fed Proc. 1969;28:1029–34.
Chaffee RR, Allen JR. Effects of ambient temperature on the resting metabolic rate of cold- and heat-acclimated Macaca mulatta. Comp Biochem Physiol A. 1973;44:1215–25.
Jakubczak LF. Food and water intakes of rats as a function of strain, age, temperature, and body weight. Physiol Behav. 1976;17:251–8.
Stroebele N, De Castro JM. Effect of ambience on food intake and food choice. Nutrition. 2004;20:821–38.
Refinetti R. Effects of food temperature and ambient temperature during a meal on food intake in the rat. Physiol Behav. 1988;43:245–7.
Westerterp-Plantenga MS, van Marken Lichtenbelt WD, Strobbe H, Schrauwen P. Energy metabolism in humans at a lowered ambient temperature. Eur J Clin Nutr. 2002;56:288–96.
Booth G, Strang JM. Changes in temperature of the skin following ingestion of food. Arch Intern Med. 1936;57:533–43.
Himms-Hagen J. Role of thermogenesis in the regulation of energy balance in relation to obesity. Can J Physiol Pharmacol. 1989;67:394–401.
Cannon B, Nedergaard J. Nonshivering thermogenesis and its adequate measurement in metabolic studies. J Exp Biol. 2011;214:242–53.
Jequier E. Thermogenic responses induced by nutrients in man: their importance in energy balance regulation. Exp Suppl. 1983;44:26–44.
Segal KR, Gutin B, Albu J, Pi-Sunyer FX. Thermic effects of food and exercise in lean and obese men of similar lean body mass. Am J Physiol. 1987;252:E110–7.
Thorne A, Hallberg D, Wahren J. Meal-induced thermogenesis in obese patients before and after weight reduction. Clin Physiol. 1989;9:481–98.
Brundin T, Thorne A, Wahren J. Heat leakage across the abdominal wall and meal-induced thermogenesis in normal-weight and obese subjects. Metabolism. 1992;41:49–55.
Claessens-van Ooijen AM, Westerterp KR, Wouters L, Schoffelen PF, van Steenhoven AA, van Marken Lichtenbelt WD. Heat production and body temperature during cooling and rewarming in overweight and lean men. Obesity (SilverSpring). 2006;14:1914–20.
• Savastano DM, Gorbach AM, Eden HS, Brady SM, Reynolds JC, Yanovski JA. Adiposity and human regional body temperature. Am J Clin Nutr. 2009;90:1124–31. Demonstration by infrared thermography of the altered thermal profile of lean and obese individuals exposed to the same ambient temperature conditions.
Krzywanski DM, Moellering DR, Fetterman JL, Dunham-Snary KJ, Sammy MJ, Ballinger SW. The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics. Lab Invest. 2011;91:1122–35.
• Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 2009;9:203–9. By housing mice within their TNZ, a defect in thermogenesis reveals an increased energetic efficiency and propensity to increased weight gain and fat accrual. Thus, a gene by environment interaction disposes toward excess weight gain and obesity phenotypes only in the absence of cold stress.
Liu X, Rossmeisl M, McClaine J, Riachi M, Harper ME, Kozak LP. Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J Clin Invest. 2003;111:399–407.
Himms-Hagen J. Impaired thermogenesis and brown fat in obesity. Can J Surg. 1984;27:125.
Rothwell NJ, Stock MJ. A role for brown adipose tissue in diet-induced thermogenesis. Obes Res. 1997;5:650–6.
Wijers SL, Saris WH, van Marken Lichtenbelt WD. Individual thermogenic responses to mild cold and overfeeding are closely related. J Clin Endocrinol Metab. 2007;92:4299–305.
Stock MJ. Gluttony and thermogenesis revisited. Int J Obes Relat Metab Disord. 1999;23:1105–17.
van Marken Lichtenbelt WD, Schrauwen P, van De KS, Westerterp-Plantenga MS. Individual variation in body temperature and energy expenditure in response to mild cold. Am J Physiol Endocrinol Metab. 2002;282:E1077–83.
Wijers SL, Saris WH, van Marken Lichtenbelt WD. Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity. Obes Rev. 2008.
• Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, et al. Functional brown adipose tissue in healthy adults. N Engl J Med. 2009;360:1518–25. Documents the presence of metabolically active BAT in healthy adult humans by PET/CT scans.
• van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med. 2009;360:1500–8. Documents the presence of metabolically active BAT in healthy adult humans by PET/CT scans using a mild cold ambient temperature exposure. Inverse associations of BAT activity with body weight and body fat are reported.
Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes. 2009.
Hany TF, Gharehpapagh E, Kamel EM, Buck A, Himms-Hagen J, von Schulthess GK. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging. 2002;29:1393–8.
Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab. 2007;293:E444–52.
Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009;360:1509–17.
Nedergaard J, Bengtsson T, Cannon B. Three years with adult human brown adipose tissue. Ann N Y Acad Sci. 2010;1212:E20–36.
Heaton JM. The distribution of brown adipose tissue in the human. J Anat. 1972;112:35–9.
Tanuma Y, Tamamoto M, Ito T, Yokochi C. The occurrence of brown adipose tissue in perirenal fat in Japanese. Arch Histol Jpn. 1975;38:43–70.
Tanuma Y, Ohata M, Ito T, Yokochi C. Possible function of human brown adipose tissue as suggested by observation on perirenal brown fats from necropsy cases of variable age groups. Arch Histol Jpn. 1976;39:117–45.
Nnodim JO. The occurrence of brown adipose in man inhabiting the tropics. Z Mikrosk Anat Forsch. 1990;104:721–8.
Lever JD, Jung RT, Nnodim JO, Leslie PJ, Symons D. Demonstration of a catecholaminergic innervation in human perirenal brown adipose tissue at various ages in the adult. Anat Rec. 1986;215:251–9.
Huttunen P, Hirvonen J, Kinnula V. The occurrence of brown adipose tissue in outdoor workers. Eur J Appl Physiol Occup Physiol. 1981;46:339–45.
Huttunen P, Kortelainen ML. Long-term alcohol consumption and brown adipose tissue in man. Eur J Appl Physiol Occup Physiol. 1990;60:418–24.
Himms-Hagen J. Obesity may be due to a malfunctioning of brown fat. Can Med Assoc J. 1979;121:1361–4.
Himms-Hagen J. Does brown adipose tissue (BAT) have a role in the physiology or treatment of human obesity? Rev Endocr Metab Disord. 2001;2:395–401.
Orava J, Nuutila P, Lidell ME, Oikonen V, Noponen T, Viljanen T, Scheinin M, Taittonen M, Niemi T, Enerback S, Virtanen KA. Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab. 2011;14:272–9.
Lee P, Greenfield JR, Ho KK, Fulham MJ. A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab. 2010;299:E601–6.
Cannon B, Nedergaard J. Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). Int J Obes (Lond). 2010;34 Suppl 1:S7–S16.
Hu HH, Smith Jr DL, Nayak KS, Goran MI, Nagy TR. Identification of brown adipose tissue in mice with fat-water IDEAL-MRI. J Magn Reson Imaging. 2010;31:1195–202.
Hamilton G, Smith Jr DL, Bydder M, Nayak KS, Hu HH. MR properties of brown and white adipose tissues. J Magn Reson Imaging. 2011;34:468–73.
Branca RT, Warren WS. In vivo brown adipose tissue detection and characterization using water-lipid intermolecular zero-quantum coherences. Magn Reson Med. 2011;65:313–9.
Wagner JA, Robinson S, Marino RP. Age and temperature regulation of humans in neutral and cold environments. J Appl Physiol. 1974;37:562–5.
Anderson GS. Human morphology and temperature regulation. Int J Biometeorol. 1999;43:99–109.
Buskirk ER, Lundegren H, Magnusson L. Heat acclimatization patterns in obese and lean individuals. Ann N Y Acad Sci. 1965;131:637–53.
Chung NK, Pin CH. Obesity and the occurrence of heat disorders. Mil Med. 1996;161:739–42.
Livingstone SD, Grayson J, Frim J, Allen CL, Limmer RE. Effect of cold exposure on various sites of core temperature measurements. J Appl Physiol. 1983;54:1025–31.
Dauncey MJ. Influence of mild cold on 24 h energy expenditure, resting metabolism and diet-induced thermogenesis. Br J Nutr. 1981;45:257–67.
Warwick PM, Busby R. Influence of mild cold on 24 h energy expenditure in ‘normally’ clothed adults. Br J Nutr. 1990;63:481–8.
Westerterp-Plantenga MS, van Marken Lichtenbelt WD, Cilissen C MS, Top S. Energy metabolism in women during short exposure to the thermoneutral zone. Physiol Behav. 2002;75:227–35.
Wilkerson JE, Raven PB, Horvath SM. Critical temperature of unacclimatized male Caucasians. J Appl Physiol. 1972;33:451–5.
Yoshimura M, Yoshimura H. Cold tolerance and critical temperature of the Japanese. Int J Biometeorol. 1969;13:163–72.
van Ooijen AM, van Marken Lichtenbelt WD, van Steenhoven AA, Westerterp KR. Seasonal changes in metabolic and temperature responses to cold air in humans. Physiol Behav. 2004;82:545–53.
Kashiwazaki H, Dejima Y, Suzuki T. Influence of upper and lower thermoneutral room temperatures (20 degrees C and 25 degrees C) on fasting and post-prandial resting metabolism under different outdoor temperatures. Eur J Clin Nutr. 1990;44:405–13.
Blaza S, Garrow JS. Thermogenic response to temperature, exercise and food stimuli in lean and obese women, studied by 24 h direct calorimetry. Br J Nutr. 1983;49:171–80.
Celi FS, Brychta RJ, Linderman JD, Butler PW, Alberobello AT, Smith S, Courville AB, Lai EW, Costello R, Skarulis MC, Csako G, Remaley A, Pacak K, Chen KY. Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults. Eur J Endocrinol. 2010;163:863–72.
Steiniger J, Karst H, Noack R, Steglich HD. Diet-induced thermogenesis in man: thermic effects of single protein and carbohydrate test meals in lean and obese subjects. Ann Nutr Metab. 1987;31:117–25.
Jensen AH, Kuhlman DE, Becker DE, Harmon BG. Response of growing-finishing swine to different housing environments during winter seasons. J Anim Sci. 1969;29:451–6.
Young BA. Cold stress as it affects animal production. J Anim Sci. 1981;52:154–63.
Berg F, Gustafson U, Andersson L. The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage: a genetic explanation for poor thermoregulation in piglets. PLoS Genet. 2006;2:e129.
Mezentseva NV, Kumaratilake JS, Newman SA. The brown adipocyte differentiation pathway in birds: an evolutionary road not taken. BMC Biol. 2008;6:17.
Overton JM. Phenotyping small animals as models for the human metabolic syndrome: thermoneutrality matters. Int J Obes (Lond). 2010;34 Suppl 2:S53–8.