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Minimal Eliciting Allergic Contact Dermatitis Concentrations in Normal versus Damaged Skin: Clinical and Toxicologic Relevance

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Abstract

Purpose of Review

Skin permeability often increases in skin with impaired barrier function resulting in possibly a higher susceptibility to allergen minimal eliciting doses.

Recent Findings

This overview summarizes data to be utilized in dermatotoxicology by comparing the minimal eliciting allergic contact dermatitis concentrations (MEC) between normal and damaged skin. This serves to demonstrate the higher propensity to allergic elicitation in damaged skin and expands the industrial knowledge of the impact of allergens on damaged skin.

Summary

The data helps to determine reasonable safe exposure concentrations in cosmetic and skin care products.

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Acknowledgements

The authors wish to thank Dr. Aria Vazirnia for reviewing their manuscript.

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Authors and Affiliations

  1. University of California Medical School, San Francisco, CA, 94143, USA

    Nazanin Azizi, Le Hanh Dung Do & Howard I Maibach

  2. Western University of Health and Science, Pomona, CA, 91766, USA

    Farnaz Azizi

Authors
  1. Nazanin Azizi
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  2. Farnaz Azizi
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  3. Le Hanh Dung Do
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  4. Howard I Maibach
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Contributions

Nazanin Azizi: conceptualization, writing original draft (lead); Farnaz Azizi: writing, review and editing (equal). Le Hanh dung Do: review and editing (equal); Howard I Maibach: conceptualization, review and editing (equal).

Corresponding author

Correspondence to Nazanin Azizi.

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Azizi, N., Azizi, F., Do, L.H.D. et al. Minimal Eliciting Allergic Contact Dermatitis Concentrations in Normal versus Damaged Skin: Clinical and Toxicologic Relevance. Curr Derm Rep 12, 296–299 (2023). https://doi.org/10.1007/s13671-023-00401-z

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  • DOI: https://doi.org/10.1007/s13671-023-00401-z

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