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Recognition and Management of Toxic Erythema of Chemotherapy for the Inpatient Dermatologist


Purpose of Review

Toxic erythema of chemotherapy is an umbrella term for several non-allergic cutaneous reactions to chemotherapeutic agents. Given the heterogenous range of presentations, we will review the differential diagnoses and treatment approaches, particularly for hospitalized patients.

Recent Findings

Early recognition, holding chemotherapy, or dose reduction and monitoring fluid balance for severely ill patients is the mainstay of treatment. Supportive care with topical steroids, emollients, and wound care have shown benefit.


Toxic erythema of chemotherapy can mimic several common eruptions seen in oncologic patients. The recognition of both clinical and pathological features by inpatient dermatologists allows for appropriate management, and dose reduction if necessary, in order for patients to continue oncologic treatment.

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Correspondence to Lida Zheng.

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Lee, N., Zheng, L. Recognition and Management of Toxic Erythema of Chemotherapy for the Inpatient Dermatologist. Curr Derm Rep (2021).

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  • Chemotherapy
  • Oncodermatology
  • Hand-foot syndrome
  • Toxic erythema of chemotherapy