Purpose of Review
To provide an up-to-date, customizable approach to the worker presenting with dermatitis.
Occupational contact dermatitis (OCD) is often a result of combined allergic, irritant, and endogenous factors. Potential causes of OCD can be categorized in 3 main groupings: workplace materials, personal protective equipment, and skin care. Although patterns of dermatitis may provide some indication of the etiological factor(s), patch testing remains essential in the diagnosis of allergic OCD. Management of OCD may require changes in workplace practices to reduce worker exposure to the causative agents and improve skin care practices.
OCD is a multifaceted condition with significant consequences for affected workers and their families, employers, and insurers. A methodical and individualized approach to the patient with OCD should ensure timely and accurate diagnosis(es).
Occupational contact dermatitis (OCD) encompasses a vast array of clinical presentations and underlying causes. Each worker is unique, having specific job tasks to accomplish as well as personal factors, such as atopic tendencies, that need to be considered. Thus, management of workers suffering from OCD must account for individual circumstances.
Although this may seem like a daunting task for the busy clinician, occupational dermatology can prove to be a very rewarding practice. The purpose of this review is to provide an up-to-date, customizable approach to the worker presenting with dermatitis.
Occupational Contact Dermatitis
Contact dermatitis can be defined as an inflammatory skin condition, usually eczematous in nature, induced by exposure to an external irritant or allergen. Allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD) are distinct entities. ICD can be defined as a non-immunological, non-specific reaction of the skin to an irritant. However, this definition is too simplistic. By damaging epidermal skin cells, an irritant causes a non-specific immune response which will not confer protective immunity to the host . ACD on the other hand is an adaptive immune response toward chemicals penetrating the skin. It is a type IV, delayed, or cell-mediated immunological reaction. ACD occurs in a two-phase process. Sensitization may occur on first exposure or at any time with subsequent exposure. Once sensitization is completed, elicitation will occur upon re-exposure . OCD, either ICD or ACD, results from exposures found in the workplace.
Endogenous factors, such as atopic eczema, greatly influence susceptibility to irritation. Contact sensitization has been shown to develop in the skin recently damaged from trauma or irritation. This may explain why some workers have minimal skin issues for months to years then “suddenly” develop ACD .
OCD is the most common occupational skin disease and constitutes up to 30% of reported occupational diseases. The average incidence rate of registered OCD ranges from 0.5 to 1.9 cases per 1 000 full-time workers per year . There are a variety of sources of information about OCD and its causative agents . Tables 2 and 3 list some of the common causes of OCD [5•, 6–8]. Negative impacts of OCD include reduced function, quality of life, work disruption, and economic effects .
Early Detection and Prevention
Studies have demonstrated a significant time between onset of symptoms and seeking health care, an average of 8.6 months  to more than 30 months . Workers’ fear of job loss is a major factor in explaining this delay; many first attempt to treat their skin problem on their own before seeking help .
Delay in seeking care and in diagnosis often leads to longer exposure to the causative agent. This has been shown to correlate with poorer prognosis . As early identification and management improves outcomes, screening to detect early disease would be desirable but is difficult to achieve in practice. A validated screening tool for hand dermatitis in health care workers has been developed as a self-administered questionnaire . Limited information is available regarding its usability in other work environments.
Approach to the Worker with Suspected Occupational Contact Dermatitis
OCD is a multifactorial disease and is often a result of combined allergic, irritant, and endogenous factors. When a worker seeks care for suspected OCD, a methodical approach is necessary . A complete occupational history including work exposure assessment must be conducted. Physical examination may also provide clues as to causative agent, but thorough investigations, including comprehensive patch testing to suspect workplace substances, are of paramount importance in identifying the correct diagnosis. A significant step in the management of OCD is establishing causality as this will influence the choice of preventive measures, the prognosis for successful return to current/modified work, and the outcome of workers’ compensation adjudications. This is facilitated by the physician’s acquisition of fundamental knowledge about the most common causes of OCD and familiarity with the industries that employ most workers in their communities.
A detailed exposure history is essential in the initial and continuing evaluation of the patient with suspected OCD . A number of etiological factors may be present; the astute clinician must have a clear understanding of individual job tasks as well as types and routes of cutaneous exposures in the workplace. Table 1 lists the information that should be gathered from the occupational history [6, 14].
OCD most commonly affects the hands, followed by the wrists, forearms, and face . Still, the specific areas affected may vary depending on the type of contact triggering the dermatitis, the causative allergens, and whether the underlying mechanism is allergic, irritant, or both. Important aspects to consider are the possible routes of exposure. An irritant or allergen may come in contact with the skin through direct contact, aerosolized particles (airborne contact), transfer (from touching the face or genitalia for example), or even from a partner (connubial dermatitis). Although one cannot rely solely on clinical findings to identify the cause(s) of OCD, patterns of dermatitis may provide some indication of the etiological factor(s) (Figs. 1 and 2) .
Common clinical patterns of hand dermatitis are as follows:
Frequent hand washing will induce dermatitis to first appear on the interdigital areas (Fig. 1a). The interdigital space creates occlusion, increasing the irritant potential of the remaining water and soaps left on hands that have been inadequately rinsed and dried.
A typical pattern of exogenous hand dermatitis will present with red and scaly plaques on the dorsal hands and inner wrists (Fig. 1b). This pattern is a common presentation for ACD to rubber accelerators in gloves, classically with a well-defined line of demarcation that extends to the outer edge of the cuff of the glove.
ACD to metals found in ring jewelry or ICD induced by trapped water under the ring will present with very localized dermatitis on the ring bearing finger (Fig. 1c).
Wet work may induce chronic paronychia, which is frequently aggravated by the habit of removing nail cuticles by the patient (Fig. 1d).
Grip hand dermatitis generally presents with hyperkeratotic plaques with mild or absent underlying inflammation in the areas of repeated friction (Fig. 1e).
Workers manipulating small objects may develop dermatitis of the first 3 digits, which may be of allergic or frictional (irritant) origin (Fig. 1f).
Common clinical patterns of facial dermatitis are as follows:
Airborne contact dermatitis classically presents with a diffuse facial dermatitis which may involve the upper eyelids and submental and retroauricular areas (Fig. 2a), helping to differentiate it from photocontact dermatitis. The beak sign (i.e., nasal ridge and/or tip sparing) may result from increased sebaceous gland concentration/activity preventing penetration of the epidermal barrier by aerosolized, water-soluble irritants. It may also serve as an important clinical clue to airborne contact dermatitis .
Photocontact dermatitis will affect areas exposed to light, sparing the upper eyelids, nasolabial folds, and submental and retroauricular areas (Wilkinson’s triangle). The distinction between photocontact and airborne dermatitis may be difficult to make .
Lateral facial dermatitis involving the pre-auricular areas, post-auricular areas, jaw lines, and/or lateral neck may be due to rinse-off hair products . This will also affect the eyelids depending on the forward or backward rinse-off habits (Fig. 2b).
Contact dermatitis from face cream or make-up will predominantly affect the cheeks, forehead, and chin, but the areas affected may differ depending on the pattern of application (Fig. 2c).
Goggles may produce a localized periorbital dermatitis (Fig. 2d).
Personal protective equipment such as face shields, masks, and protective glasses will induce dermatitis at their specific sites of contact (Fig. 2e).
Causes of Occupational Contact Dermatitis
When OCD is suspected, it is useful to categorize potential causes into 3 main groupings: workplace materials, personal protective equipment (PPE), and skin care.
Workplace materials include substances the worker contacts as part of the work practice and as part of work-related hand hygiene. General information about work products is obtained during the occupational history with further important details found through review of safety data sheets (SDS). Although often incomplete, the SDS provide a general inventory of the categories of products used at work, can help guide appropriate patch testing, and facilitate custom patch testing if deemed necessary. SDS for products provided for hand hygiene must also be reviewed and their labels consulted for ingredient lists.
Allergens in Workplace Materials
ACD develops with repeat exposure to chemical allergens. Workers may contact a potential allergen many times over many months without any problems before becoming sensitized and developing ACD. Usually, only one or very few workers will be affected.
The North American Contact Dermatitis Group (NACDG), a group of Canadian and US dermatologists who evaluate patients with suspected ACD using a standardized set of allergens, recently reported a retrospective analysis of OCD from 2001 to 2016, with a focus on ACD [5•]. The most common clinically relevant occupational patch test substances were rubber accelerators (carba mix, thiuram mix, and diphenylguanidine), methylisothiazolinone, bisphenol A epoxy resin, formaldehyde, nickel, potassium dichromate, 2-hydroxyethyl methacrylate, and cobalt (Table 2). Similarly, the European Surveillance System on Contact Allergies (ESSCA) network reported their results from 2000 to 2012 with the European baseline series for patients with OCD . The allergens with the strongest occupational association were similar to the NACDG profile.
Irritants in the Workplace
When thorough patch testing does not identify a contact allergen, the diagnosis might then be ICD. Although susceptibility varies among individuals, given sufficient exposure to an irritant, anyone can develop ICD [7•]. The clinical spectrum of ICD is broad and often indistinguishable from ACD and other types of eczema .
High-risk occupations for the development of ICD include medical personnel, hairdressers, metalworkers, food workers, and construction and cement workers [7•]. Strong irritants such as alkalis, acids, and solvents may rapidly induce ICD. However, the most common type of ICD is caused by repetitive exposure to a weak irritant or wet work over a longer period of time [7•]. Table 3 lists the common irritants from the workplace [6–8]. It is important to note that many substances have irritant properties as well as allergic potential.
Personal Protective Equipment
Personal protective equipment (PPE) is of great value to prevent contact with environmental irritants, allergens, and/or microbial agents. However, PPE can also be the source of the problem, through the development of a contact allergy to one or more of its components or ICD through friction, pressure, or sweat.
Prolonged occlusion from rubber gloves has been defined as wearing gloves > 2 h/day or change of gloves > 20 times/day . Prolonged glove wearing creates occlusion, preventing normal evaporation from the skin surface and resulting in an accumulation of moisture. Secondary elevated temperature and sweating can lead to increased skin pH and the induction of ICD . Once the integrity of the skin barrier is breached, there is an increased risk of subsequent contact allergy to PPE, work substances, or topical treatment.
Facial PPE often induce ICD through friction and pressure and rarely may induce ACD . Table 4 lists the potential allergens present in different PPE as well as mechanisms by which they may induce ICD.
Management of primary contact dermatitis may sometimes result in secondary contact dermatitis. Workers will try different topical remedies before seeking help, including topical antibiotics, moisturizers, and natural products. Topical corticosteroids or antifungals may also be prescribed. All of these have the potential to cause ACD to one or more of their constituents. This should be considered, particularly if the skin condition was noted to worsen with the use of some of these products . Potential allergens include corticosteroid molecules, topical antibiotics, local anesthetics, and non-medicinal ingredients including preservatives, vehicles, emollients, and fragrances [24•]. Skin care may also be the cause of ICD.
Investigating Workers with Possible Occupational Contact Dermatitis
The gold standard in the workup of a worker with possible ACD is patch testing. A standard screening series of allergens is useful to detect most common allergens. A detailed NACDG analysis of OCD showed that 81.7% of patients with occupational ACD had positive reactions to only NACDG screening series allergens, 13.1% also reacted to ≥ 1 supplemental allergen(s), and 5.2% only had positive reactions to ≥ 1 supplemental allergen(s). For patients tested to supplemental allergens, top sources were adhesives/glues/bonding agents, hair dyes, gloves, coatings, moisturizers/lotions/creams, and metalworking fluids [5•]. Testing with supplemental allergens is recommended in cases of OCD, given the specific contacts that may be encountered in the workplace. For example, testing with a rubber series has greater sensitivity than patch testing to actual workplace gloves [25•]. Supplemental series of allergens are available for common occupations, such as hairdressers and dental workers.
Commercially produced standardized patch test extracts are not available for a number of potentially allergenic workplace materials. Additive value of testing with patients’ own products has been proven in general  as well as for specific types of products such as leave-on cosmetics [25•], epoxy resins , isocyanates , and metalworking fluids  to name a few. Therefore, many patients with suspected OCD should be considered for custom testing. This involves patch testing patients with products from work including chemicals, hand cleansers, and personal protective equipment, as well as their personal care products .
Testing with Workplace Materials
Substances not available for testing in standardized series will be identified by reviewing the SDS . Products may be requested from the workplace and sent to the clinic directly. Suitable ranges of concentrations and vehicles can be obtained by consulting a comprehensive reference manual (DeGroot patch testing) . Unidentified substances as well as known irritants should not be tested due to the risk of inducing local or potentially even systemic adverse reactions . Workplace substances should be diluted appropriately by an interested and experienced chemist or by a compounding pharmacist. Guides for preparation of custom allergens are available, detailing the necessary equipment, dilution methods, and role for extraction . With proper dilutions, most workplace materials may be tested with classic patch testing (occlusive testing). Other methods of testing custom materials should be considered in specific settings (Table 5) [32−37]. In research settings and for publication purposes, testing controls are necessary to confirm the validity of the reaction and to eliminate the possibility of an irritant reaction. Although confirmation of test results using these methods are ideal, it is often not feasible in the usual clinical setting. In the authors’ opinion, the inability of testing controls should not prevent custom testing.
Establishing a Diagnosis of Occupational Dermatitis
Diagnosing OCD may prove to be difficult as there are no characteristic clinical or histological features. Mathias  proposed 7 criteria for establishing occupational causation and occupational aggravation of contact dermatitis (ACD or ICD) (Table 6). Positive answers to 4 or more of the 7 criteria are considered sufficient to establish occupational causation. Clear yes or no answers are not always possible in complicated cases. Mathias criteria have been validated to provide a likelihood of 50% or more in establishing a connection between contact dermatitis and occupation. They thus may be helpful in medicolegal cases .
Return to Work
Management of OCD may require changes in workplace practices to reduce worker exposure to the causative agents and improve skin care practices. Effective communication between the physician, worker, workplace, and insurer is a key principle that supports successful return to work (RTW). Clear recommendations for the workplace are indispensable. A skin-specific “workplace prescription” has been developed and tested for practicality in real-life settings . It provides specific advice to the worker and the employer on recommended preventive strategies including work restrictions to facilitate modified work, choice of PPE, appropriate hand hygiene, and treatment. A graduated trial of RTW with ongoing skin monitoring to detect early recurrence has been used successfully .
Emerging Topics in OCD
The COVID-19 pandemic has been a pervasive force in the year 2020, and the effects of this pandemic have been a major theme in occupational health. A systematic review of facial occupational dermatoses due to personal protective equipment revealed that ACD and ICD are most common, followed by acneiform eruptions and contact urticaria [42•]. Multiple publications describe and analyze the cutaneous side effects of PPE and intensified hand hygiene, consistently finding that OCD is the predominant observed reaction [43−45]. With respect to hand dermatitis, alcohol-based hand sanitizers with moisturizers have the least sensitizing and irritancy potential compared to soaps and synthetic detergents . In a study in health care professionals, the provision of recommendations which included specific product names was found to be superior to general recommendations alone .
OCD is a multifaceted condition with significant consequences for affected workers and their families, employers, and insurers. A methodical and individualized approach to the patient with OCD should ensure timely and accurate diagnosis(es). Appropriate management of OCD can then be instituted, with better outcomes for the worker as well as for all parties involved.
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Houle, MC., Holness, D.L. & DeKoven, J. Occupational Contact Dermatitis: An Individualized Approach to the Worker with Dermatitis. Curr Derm Rep (2021). https://doi.org/10.1007/s13671-021-00339-0
- Irritant contact dermatitis
- Occupational contact dermatitis
- Patch testing