Abstract
Purpose of Review
Use of essential oils (EOs) has become popular due to consumer demand for natural products. Despite the widespread perception that natural ingredients are safe, allergic contact dermatitis (ACD) is a well-described complication of EO use. This article provides a comprehensive overview regarding allergenicity, prevalence of positive patch test reactions, and sources of exposure associated with EOs.
Recent Findings
Approximately 80 different EOs have been implicated in contact allergy. Patch testing EOs is important for identifying sensitivity not detected by screening fragrance allergens. Clinical presentation depends on the specific EO and method of use.
Summary
EOs are complex substances of highly variable composition which may cause ACD. Due to popularity and widespread use, clinicians should ask patients about EO use. Patch testing is an important tool in the diagnosis and management of contact allergy to EOs.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as:
• Of importance
Burt S. Essential oils: their antibacterial properties and potential applications in foods—a review. Int J Food Microbiol. 2004;94(3):223–53. https://doi.org/10.1016/j.ijfoodmicro.2004.03.022.
Kubeczka KH: History and sources of essential oil research. In: Başer, Buchbauer, Başer, K. H. C., Buchbauer, Gerhard. Handbook of Essential Oils : Science, Technology, and Applications. Third edition. CRC Press; 2021.
Plant J, Johnson S. Identifying pharmaceutical grade essential oils and using them safely and effectively. In: Bakhru A. Nutrition and Integrative Medicine: a Primer for Clinicians. 1st edition. CRC Press, an imprint of Taylor and Francis; 2018.
• Goodier MC, Zhang AJ, Nikle AB, Hylwa SA, Goldfarb NI, Warshaw EM. Use of essential oils: a general population survey. Contact Dermatitis. 2019;80(6):391–3. https://doi.org/10.1111/cod.13198. First study to evaluate usage patterns of EOs among a United States general population. Of 282 individuals surveyed, 47.2% reported use of EOs and 46.7% used EOs to treat medical conditions/symptoms. Over half (54.5%) reported diffusing EOs and 30.3% incorporated EOs into homemade products. The reasons cited for EO use were mainly a desire for alternative treatments (53.4%) and the opinion that EOs are safer than traditional therapies (47.6%).
Schäfer T. Complementary and alternative medicine (CAM) and atopic eczema. Allergol Select. 2017;1(1):44–52. https://doi.org/10.5414/ALX01287E.
National Association for Holistic Aromatherapy (NAHA). Methods of Application. Available at: https://naha.org/explore-aromatherapy/about-aromatherapy/methods-of-application/. Accessed on 7 Mar 2021.
Ahuja K, Singh, S. Essential oils market size by application (orange oil, lemon oil, eucalyptus oil, clove oil, peppermint oil, jasmine oil, rosemary oil, cornmint oil, citronella oil, geranium, spearmint oil, lavender oil, tea tree oil and others) by application (food & beverage, aromatherapy, cosmetics & toiletries, pharmaceuticals, cleaning & home care, animal feed, fragrances and others) Industry Analysis Report, Regional Outlook, Growth Potential, Competitive Market Share & Forecast, 2019–2026. Global Market Insights, Inc. 2019. Available at: https://www.gminsights.com/industry-analysis/essential-oil-market. Accessed on 11 Dec 2020.
de Groot AC, Schmidt E. Essential oils, Part I: Introduction. Dermatitis. 2016;27(2):39–42. https://doi.org/10.1097/DER.0000000000000175.
de Groot A, Schmidt E. Part II: General aspects. Dermatitis. 2016;27(2):43–9. https://doi.org/10.1097/DER.0000000000000174.
de Groot AC, Schmidt E. Essential oils, Part III: Chemical Composition. Dermatitis. 2016;27(4):161–9. https://doi.org/10.1097/DER.0000000000000193.
de Groot AC, Schmidt E. Essential oils, Part IV: Contact Allergy. Dermatitis. 2016;27(4):170–5. https://doi.org/10.1097/DER.0000000000000197.
de Groot A, Schmidt E. Essential oils, Part V: Peppermint Oil, Lavender Oil, and Lemongrass Oil. Dermatitis. 2016;27(6):325–32. https://doi.org/10.1097/DER.0000000000000218.
de Groot AC, Schmidt E. Essential oils, Part VI: Sandalwood Oil, Ylang-Ylang Oil, and Jasmine Absolute. Dermatitis. 2017;28(1):14–21. https://doi.org/10.1097/DER.0000000000000241.
ISO 9235:2013 Aromatic natural raw materials – vocabulary. Available at: https://www.iso.org/obp/ui/#iso:std:iso:9235:ed-2:v1:en. Accessed on 1 Feb 2021.
Britannica, The Editors of Encyclopedia. “Essential oil”. Encyclopedia Britannica, 15 May. 2019. Available at: https://www.britannica.com/topic/essential-oil. Accessed on 17 Apr 2021.
Dima C, Dima S. Essential oils in foods: extraction, stabilization and toxicity. Curr Opin Food Sci. 2015;5:29–35. https://doi.org/10.1016/j.cofs.2015.07.003.
Rao PV, Gan SH. Cinnamon: a multifaceted medicinal plant. Evid Based Complement Alternat Med. 2014;2014: 642942. https://doi.org/10.1155/2014/642942.
Bråred Christensson J, Forsström P, Wennberg AM, Karlberg AT, Matura M. Air oxidation increases skin irritation from fragrance terpenes. Contact Dermatitis. 2009;60(1):32–40. https://doi.org/10.1111/j.1600-0536.2008.01471.x.
Turek C, Stintzing FC. Stability of essential oils: a review. Comprehensive reviews in food science and food safety. 2013;12(1):40–53. https://doi.org/10.1111/1541-4337.12006.
Satyal P, Setzer WN. Adulteration analysis in essential oils. In: Malik S. Essential Oil Research Trends in Biosynthesis, Analytics, Industrial Applications and Biotechnological Production. Springer; 2019.
• de Groot A. Limonene Hydroperoxides. Dermatitis. 2019;30(6):331–5. https://doi.org/10.1097/DER.0000000000000465. A review article on contact allergy to limonene and limonene hydroperoxides examining sensitizing potency, prevalence of positive reactions with patch testing, and sources of exposure.
Sköld M, Börje A, Harambasic E, Karlberg AT. Contact allergens formed on air exposure of linalool. Identification and quantification of primary and secondary oxidation products and the effect on skin sensitization. Chem Res Toxicol. 2004;17(12):1697–705. https://doi.org/10.1021/tx049831z.
Rutherford T, Nixon R, Tam M, Tate B. Allergy to tea tree oil: retrospective review of 41 cases with positive patch tests over 4.5 years. Australas J Dermatol. 2007;48(2):83–7. https://doi.org/10.1111/j.1440-0960.2007.00341.x.
Hagvall L, Sköld M, Bråred-Christensson J, Börje A, Karlberg AT. Lavender oil lacks natural protection against autoxidation, forming strong contact allergens on air exposure. Contact Dermatitis. 2008;59(3):143–50. https://doi.org/10.1111/j.1600-0536.2008.01402.x.
Hagvall L, Christensson JB. Patch testing with main sensitizers does not detect all cases of contact allergy to oxidized lavender oil. Acta Derm Venereol. 2016;96(5):679–83. https://doi.org/10.2340/00015555-2319.
Schaller M, Korting HC. Allergic airborne contact dermatitis from essential oils used in aromatherapy. Clin Exp Dermatol. 1995;20(2):143–5. https://doi.org/10.1111/j.1365-2230.1995.tb02719.x.
Storan ER, Nolan U, Kirby B. Allergic contact dermatitis caused by the tea tree oil-containing hydrogel Burnshield®. Contact Dermatitis. 2016;74(5):309–10. https://doi.org/10.1111/cod.12531.
Kartal D, Kartal L, Çınar SL, Borlu M. Allergic contact dermatitis caused by both eucalyptus oil and spruce oil. International Journal of Medical and Pharmaceutical Case Reports. 2016;7(2):1–3. https://doi.org/10.9734/IJMPCR/2016/25115.
Bourgeois P, Goossens A. Allergic contact cheilitis caused by menthol in toothpaste and throat medication: a case report. Contact Dermatitis. 2016;75(2):113–5. https://doi.org/10.1111/cod.12571.
Huber J, deShazo R, Powell D, Duffy K, Hull C. Erythema multiforme-like allergic contact dermatitis to turmeric essential oil. Dermatitis. 2016;27(6):385–6. https://doi.org/10.1097/DER.0000000000000213.
Tempark T, Chatproedprai S, Wananukul S. Localized contact dermatitis from Ferula assa-foetida oleo-gum-resin essential oil, a traditional topical preparation for stomach ache and flatulence. Indian J Dermatol Venereol Leprol. 2016;82(4):467. https://doi.org/10.4103/0378-6323.182969.
Brown ME, Browning JC. A case of psoriasis replaced by allergic contact dermatitis in a 12-year-old boy. Pediatr Dermatol. 2016;33(2):e125–6. https://doi.org/10.1111/pde.12737.
Grey KR, Hagen SL, Warshaw EM. Essential oils: emerging “medicaments.” Dermatitis. 2016;27(4):227–8. https://doi.org/10.1097/DER.0000000000000202.
Hagen SL, Grey KR, Warshaw EM. Patch Testing to Essential Oils. Dermatitis. 2016;27(6):382–4. https://doi.org/10.1097/DER.0000000000000207.
Lauriola MM, Corazza M. Allergic contact dermatitis caused by argan oil, neem oil, and Mimosa tenuiflora. Contact Dermatitis. 2016;75(6):388–90. https://doi.org/10.1111/cod.12665.
Bonhomme A, Poreaux C, Jouen F, Schmutz JL, Gillet P, Barbaud A. Bullous drug eruption to Nigella sativa oil: consideration of the use of a herbal medicine - clinical report and review of the literature. J Eur Acad Dermatol Venereol. 2017;31(4):e217–9. https://doi.org/10.1111/jdv.13982.
de Groot A, Jagtman BA, Woutersen M. Contact allergy to neem oil. Dermatitis. 2017;28(6):360–2. https://doi.org/10.1097/DER.0000000000000309.
Sánchez-Gilo A, Nuño González A, Gutiérrez Pascual M, Vicente Martín FJ. Airborne allergic contact dermatitis caused by neem oil. Dermatitis de contacto alérgica aerotransportada por aceite de neem. Actas Dermosifiliogr (Engl Ed). 2018;109(5):449–50. https://doi.org/10.1016/j.ad.2017.05.020.
Gaudin O, Toukal F, Hua C, et al. Association between severe acute contact dermatitis due to Nigella sativa oil and epidermal apoptosis. JAMA Dermatol. 2018;154(9):1062–5. https://doi.org/10.1001/jamadermatol.2018.2120.
Özkaya E. Cinnamon-induced airborne occupational allergic contact dermatitis in a baker: severe flare-up during patch testing. Contact Dermatitis. 2019;80(6):405–7. https://doi.org/10.1111/cod.13219.
Romita P, Calogiuri G, Bellino M, et al. Allergic contact dermatitis caused by neem oil: an underrated allergen? Contact Dermatitis. 2019;81(2):133–4. https://doi.org/10.1111/cod.13256.
Dehavay F, Kolivras A, Scheers C. Local and systemic adverse skin reactions following the use of herbal products believed to contain Nigella sativa seeds and oil. Contact Dermatitis. 2019;80(3):176–7. https://doi.org/10.1111/cod.13154.
Griggs J, Almohanna H, Ahmed A, Ren S, Tosti A. “Fresh breath” on toothpaste: peppermint as cause of cheilitis. Dermatitis. 2019;30(1):74–5. https://doi.org/10.1097/DER.0000000000000433.
Shah KM, Goldman SE, Agim NG. Airborne contact dermatitis caused by essential oils in a child. Dermatitis. 2019;30(1):79–80. https://doi.org/10.1097/DER.0000000000000430.
Corazza M, Amendolagine G, Borghi A, et al. Aromatherapy and occupational allergic contact dermatitis: two further cases caused by lavender oil and other essential oils. Contact Dermatitis. 2019;81(5):378–9. https://doi.org/10.1111/cod.13328.
Tamagawa-Mineoka R, Masuda K, Katoh N. Allergic contact dermatitis due to neem oil: a case report and mini-review. J Dermatol. 2020;47(2):e48–9. https://doi.org/10.1111/1346-8138.15182.
Kurihara F, Soria A, Lepoittevin JP, et al. Thymoquinone as a causative allergen in Nigella sativa oil contact dermatitis with cross-reactivity to tert-butylhydroquinone. Contact Dermatitis. 2020;83(2):132–4. https://doi.org/10.1111/cod.13542.
Tsimpidakis A, Rigopoulos D, Gregoriou S. Aromatherapy: cure or curse? A case report of allergic contact dermatitis caused by essential oils. Contact Dermatitis. 2020;83(2):141–3. https://doi.org/10.1111/cod.13548.
Seiller H, Kurihara F, Chasset F, Soria A, Barbaud A. Tert-butylhydroquinone is a marker for sensitivity to Nigella sativa oil allergy: five new cases. Contact Dermatitis. 2021;84(6):447–9. https://doi.org/10.1111/cod.13750.
Lauriola MM, Sena P, De Bitonto A, et al. Allergic contact dermatitis due to “therapeutic uses” of tea tree oil on the lips and toenails. Dermatitis. 2021;32(3):e40–1. https://doi.org/10.1097/DER.0000000000000649.
Martínez Campayo N, Goday Buján JJ, Capdevilla Fonseca E. Allergic contact dermatitis due to tea tree oil. Dermatitis alérgica de contacto por aceite de árbol del té. Actas Dermosifiliogr (Engl Ed). 2020;111(9):787–8. https://doi.org/10.1016/j.ad.2019.03.020.
Romita P, Foti C, Gullo G, Ambrogio F, Dimauro D, Calogiuri G. Genital allergic contact dermatitis in response to contact to thyme in a sanitary pad. Contact Dermatitis. 2020;82(3):169–70. https://doi.org/10.1111/cod.13413.
Hagvall L, Prystupa-Chalkidis K. Contact allergy to oxidized terpenes and occupational contact dermatitis in massage therapists - a case series. Contact Dermatitis. 2020;82(6):390–2. https://doi.org/10.1111/cod.13494.
Herrero-Moyano M, Capusan TM, Martínez-Mera C, Sánchez-Pérez J. Occupational allergic contact dermatitis from multiple essential oils. Contact Dermatitis. 2020;83(6):512–3. https://doi.org/10.1111/cod.13643.
Sergoynne L, Mertens M, Dendooven E, et al. Allergic contact dermatitis, mimicking atopic dermatitis, associated with the use of essential oils in “home-made” cosmetics and aromatherapy diffusers. Contact Dermatitis. 2020;83(4):311–3. https://doi.org/10.1111/cod.13580.
Bernaola M, Valls A, de Frutos C, Garcia-Abujeta JL. Occupational allergic contact dermatitis to neem oil used in natural cosmetic. Contact Dermatitis. 2020;82(6):389–90. https://doi.org/10.1111/cod.13490.
Navarro-Triviño FJ, Jadczak P, Ruiz-Villaverde R. Allergic contact dermatitis caused by Lavandula angustifolia and cross-reaction with Citrus bergamia essential oils in an aromatherapist. Int J Dermatol. 2021;60(2):241–3. https://doi.org/10.1111/ijd.15027.
Xie Z, Zhang Y, Yang YT, Su Y, Zhang H. Allergic contact dermatitis caused by a traditional Chinese medicine treatment- moxibustion. Contact Dermatitis. 2021;84(2):127–30. https://doi.org/10.1111/cod.13694.
Ochi H, Kwong HL, Lim SPR. Leonine facies in a masseuse as a result of allergic contact dermatitis. Contact Dermatitis. 2021;84(4):268–70. https://doi.org/10.1111/cod.13724.
Buonomo M, Hylwa S. Allergic contact dermatitis from Boswellia carterii (frankincense) oil [published online ahead of print, 2021 May 7]. Contact Dermatitis. 2021. https://doi.org/10.1111/cod.13881.
Hamamoto Y, Nagai K, Yasui H, et al. Cutaneous drug reaction case reports: from the world literature. Am J Clin Dermatol. 2000;1:317–22. https://doi.org/10.2165/00128071-200001050-00009.
Kooti W, Hasanzadeh-Noohi Z, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D. Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa). Chin J Nat Med. 2016;14(10):732–45. https://doi.org/10.1016/S1875-5364(16)30088-7.
Tisserand R, Young R. Essential oil safety, 2nd Edition. Edinburgh, UK: Churchill Livingstone Elsevier, 2014.
Brandão FM. Occupational allergy to lavender oil. Contact Dermatitis. 1986;15(4):249–50. https://doi.org/10.1111/j.1600-0536.1986.tb01351.x.
Romaguera C, Vilaplana J. Occupational contact dermatitis from ylang-ylang oil. Contact Dermatitis. 2000;43(4):251.
Price S, Price, Len. Aromatherapy for Health Professionals. 3rd ed.. Churchill Livingstone/Elsevier 2007.
Loveman AB. Stomatitis venenata. Report of a case of sensitivity of the mucous membranes and the skin to oil of anise. Arch Derm Syph. 1938;37:70–81. https://doi.org/10.1001/archderm.1938.01480070073009.
Clark SM, Wilkinson SM. Phototoxic contact dermatitis from 5-methoxypsoralen in aromatherapy oil. Contact Dermatitis. 1998;38(5):289–90. https://doi.org/10.1111/j.1600-0536.1998.tb05752.x.
Kaddu S, Kerl H, Wolf P. Accidental bullous phototoxic reactions to bergamot aromatherapy oil. J Am Acad Dermatol. 2001;45(3):458–61. https://doi.org/10.1067/mjd.2001.116226.
Zaynoun ST, Johnson BE, Frain-Bell W. A study of oil of bergamot and its importance as a phototoxic agent. II. Factors which affect the phototoxic reaction induced by bergamot oil and psoralen derivatives. Contact Dermatitis. 1977;3(5):225–39. https://doi.org/10.1111/j.1600-0536.1977.tb03667.x.
Pigatto PD, Legori A, Bigardi AS, et al. Gruppo Italiano Ricerca Dermatiti da Contatto ed Ambientali Italian Multicenter Study of Allergic Contact Photodermatitis: epidemiological aspects. Am J Contact Dermat. 1996;7(3):158–163.
el-Rab MO, al-Sheikh OA. Is the European standard series suitable for patch testing in Riyadh, Saudi Arabia?. Contact Dermatitis. 1995;33(5):310–314. https://doi.org/10.1111/j.1600-0536.1995.tb02044.x.
Nosbaum A, Ben Said B, Halpern SJ, Nicolas JF, Bérard F. Systemic allergic contact dermatitis to black cumin essential oil expressing as generalized erythema multiforme. Eur J Dermatol. 2011;21(3):447–8. https://doi.org/10.1684/ejd.2011.1351.
Gelot P, Bara-Passot C, Gimenez-Arnau E, Beneton N, Maillard H, Celerier P. Éruption bulleuse à l’huile de nigelle [Bullous drug eruption with Nigella sativa oil]. Ann Dermatol Venereol. 2012;139(4):287–91. https://doi.org/10.1016/j.annder.2012.01.025.
Nakayama H, Matsuo S, Hayakawa K, Takhashi K, Shigematsu T, Ota S. Pigmented cosmetic dermatitis. Int J Dermatol. 1984;23(5):299–305. https://doi.org/10.1111/j.1365-4362.1984.tb04055.x.
Magnusson B, Wilkinson DS. Cinnamic aldehyde in toothpaste. 1. Clinical aspects and patch tests. Contact Dermatitis. 1975;1(2):70–6. https://doi.org/10.1111/j.1600-0536.1975.tb05330.x.
Silvers SH. Stomatitis and dermatitis venenata with purpura, resulting from oil of cloves and oil of cassia. Dent Items Interest. 1939;61:649–51.
Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol. 1976;112(2):202–3. https://doi.org/10.1001/archderm.1976.01630260026007.
Laubach JL, Malkenson FD, Ringrose EJ. Cheilitis caused by cinnamon (cassia) oil in toothpaste. JAMA. 1953;152:404–5. https://doi.org/10.1001/jama.1953.63690050006008c.
Rudzki E, Grzywa Z. Immediate reactions to balsam of Peru, cassia oil and ethyl vanillin. Contact Dermatitis. 1976;2(6):360–1. https://doi.org/10.1111/j.1600-0536.1976.tb03080.x.
Rietschel RL. Contact urticaria from synthetic cassia oil and sorbic acid limited to the face. Contact Dermatitis. 1978;4(6):347–9. https://doi.org/10.1111/j.1600-0536.1978.tb03848.x.
Buckle, J. Essential oil toxicity and contraindications. In: Clinical Aromatherapy (Third Edition) Essential Oils in Healthcare. Churchill Livingstone; 2016.
García-Abujeta JL, de Larramendi CH, Berna JP, Palomino EM. Mud bath dermatitis due to cinnamon oil. Contact Dermatitis. 2005;52(4):234. https://doi.org/10.1111/j.0105-1873.2005.0566h.x.
Miller J. Cheilitis from sensitivity to oil of cinnamon present in bubble gum. JAMA. 1941;116:131–2. https://doi.org/10.1001/jama.1941.62820020001010.
Sparks T. Cinnamon oil burn. West J Med. 1985;142(6):835.
Connolly M, Axtell A, Hickey S, et al. Chemical burn from cinnamon oil. Eplasty. 2017;17:ic11. Published 2017 Jun 1.
Yiannias JA, el-Azhary RA, Hand JH, Pakzad SY, Rogers RS 3rd. Relevant contact sensitivities in patients with the diagnosis of oral lichen planus. J Am Acad Dermatol. 2000;42(2 Pt 1):177–182. https://doi.org/10.1016/S0190-9622(00)90123-3.
Isaacs G. Permanent local anaesthesia and anhidrosis after clove oil spillage. Lancet. 1983;1(8329):882. https://doi.org/10.1016/s0140-6736(83)91428-9.
Addo HA, Ferguson J, Johnson BE, Frain-Bell W. The relationship between exposure to fragrance materials and persistent light reaction in the photosensitivity dermatitis with actinic reticuloid syndrome. Br J Dermatol. 1982;107(3):261–74. https://doi.org/10.1111/j.1365-2133.1982.tb00356.x.
Samanta A, Agarwal K, Naskar BN, De A. The role of patch testing with Indian cosmetic series in patients with facial pigmented contact dermatitis in India. Indian J Dermatol. 2021;66(1):81–6. https://doi.org/10.4103/ijd.IJD_302_20.
Adams RM, Maibach HI. A five-year study of cosmetic reactions. J Am Acad Dermatol. 1985;13(6):1062–9. https://doi.org/10.1016/s0190-9622(85)70258-7.
Athanasiadis GI, Pfab F, Klein A, Braun-Falco M, Ring J, Ollert M. Erythema multiforme due to contact with laurel oil. Contact Dermatitis. 2007;57(2):116–8. https://doi.org/10.1111/j.1600-0536.2006.00869.x.
Uzuncakmak TK, Karadag AS, Izol B, Akdeniz N, Cobanoglu B, Taskin S. Erythema multiforme like allergic contact dermatitis associated with laurel oil: a rare presentation. Dermatol Online J. 2015;21(4):13030/qt4gm9g7rk.
Goiriz R, Delgado-Jiménez Y, Sánchez-Pérez J, García-Diez A. Photoallergic contact dermatitis from lavender oil in topical ketoprofen. Contact Dermatitis. 2007;57(6):381–2. https://doi.org/10.1111/j.1600-0536.2007.01102.x.
Serrano G, Pujol C, Cuadra J, Gallo S, Aliaga A. Riehl’s melanosis: pigmented contact dermatitis caused by fragrances. J Am Acad Dermatol. 1989;21(5 Pt 2):1057–60. https://doi.org/10.1016/s0190-9622(89)70295-4.
Kejlová K, Jírová D, Bendová H, Gajdoš P, Kolářová H. Phototoxicity of essential oils intended for cosmetic use. Toxicol In Vitro. 2010;24(8):2084–9. https://doi.org/10.1016/j.tiv.2010.07.025.
Suter, Valerie G. A, Warnakulasuriya, Saman. The role of patch testing in the management of oral lichenoid reactions. J Oral Pathol Med. 2016;45(1):48–57. https://doi.org/10.1111/jop.12328
Morton CA, Garioch J, Todd P, Lamey PJ, Forsyth A. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis. 1995;32(5):281–4. https://doi.org/10.1111/j.1600-0536.1995.tb00781.x.
Zhou LL, Pratt M. Allergic contact cheilitis from a variety of lip balm ingredients. J Cutan Med Surg. 2018;22(3):333–5. https://doi.org/10.1177/1203475417738969.
Francalanci S, Sertoli A, Giorgini S, Pigatto P, Santucci B, Valsecchi R. Multicentre study of allergic contact cheilitis from toothpastes. Contact Dermatitis. 2000;43(4):216–22. https://doi.org/10.1034/j.1600-0536.2000.043004216.x.
Parys BT. Chemical burns resulting from contact with peppermint oil mar: a case report. Burns Incl Therm Inj. 1983;9(5):374–5. https://doi.org/10.1016/0305-4179(83)90087-6.
Tamir S, Davidovich Z, Attal P, Eliashar R. Peppermint oil chemical burn. Otolaryngol Head Neck Surg. 2005;133(5):801–2. https://doi.org/10.1016/j.otohns.2005.05.047.
Lewis FM, Shah M, Gawkrodger DJ. Contact sensitivity to food additives can cause oral and perioral symptoms. Contact Dermatitis. 1995;33(6):429–30. https://doi.org/10.1111/j.1600-0536.1995.tb02082.x.
Clayton R, Orton D. Contact allergy to spearmint oil in a patient with oral lichen planus. Contact Dermatitis. 2004;51(5–6):314–5. https://doi.org/10.1111/j.0105-1873.2004.0459f.x.
Skrebova N, Brocks K, Karlsmark T. Allergic contact cheilitis from spearmint oil. Contact Dermatitis. 1998;39(1):35. https://doi.org/10.1111/j.1600-0536.1998.tb05813.x.
Khanna M, Qasem K, Sasseville D. Allergic contact dermatitis to tea tree oil with erythema multiforme-like id reaction. Am J Contact Dermat. 2000;11(4):238–42. https://doi.org/10.1053/ajcd.2000.7631.
Puig L, Alomar A, Randazzo L, Cuatrecasas M. Erythema multiforme-like reaction caused by topical application of thuja essential oil. Am J Contact Dermatitis. 1994;5:94–7.
Mang R, Stege H, Krutmann J. Mechanisms of phototoxic and photoallergic reactions. In: Frosch PJ, Menne T, Lepoittevin J-P, eds. Textbook of contact dermatitis, 4th edn. Springer; 2006.
Oppenheim M. Local Sensitization of the skin to Grenz rays by bergamot oil. J Investig Dermatol. 1947;8(5):255–62. https://doi.org/10.1038/jid.1947.37.
Gruson LM, Chang MW. Berloque dermatitis mimicking child abuse. Arch Pediatr Adolesc Med. 2002;156(11):1091–3. https://doi.org/10.1001/archpedi.156.11.1091.
Wang L, Sterling B, Don P. Berloque dermatitis induced by “Florida water.” Cutis. 2002;70(1):29–30.
Ebihara T, Nakayama H. Pigmented contact dermatitis. Clin Dermatol. 1997;15(4):593–9. https://doi.org/10.1016/s0738-081x(97)00072-2.
Lauriola MM, Sena P, De Bitonto A, Corazza M. Irritant contact dermatitis after a curious therapeutic use of oregano essential oil. Contact Dermatitis. 2020;83(2):129–30. https://doi.org/10.1111/cod.13540.
Johansen JD. Fragrance contact allergy: a clinical review. Am J Clin Dermatol. 2003;4(11):789–98. https://doi.org/10.2165/00128071-200304110-00006.
Veverka KK, Hall MR, Yiannias JA, et al. Trends in patch testing with the Mayo Clinic Standard Series, 2011–2015. Dermatitis. 2018;29(6):310–5. https://doi.org/10.1097/DER.0000000000000411.
• DeKoven JG, Silverberg JI, Warshaw EM, et al. North American contact dermatitis group patch test results: 2017–2018. Dermatitis. 2021;32(2):111–123. https://doi.org/10.1097/DER.0000000000000729. Retrospective analysis of 4,947 patients patch tested to the North American Contact Dermatitis Group screening series of 70 allergens (including three EOs) from 2017–2018. The frequency of positive patch test reactions to EOs (in increasing order) was: peppermint oil (0.6%), oxidized tea tree oil (1.0%) and ylang-ylang oil (1.3%). The prevalence of positive reactions to ylang-ylang oil was significantly increased from the previous cycle and when compared to the previous 10 years of patch testing this substance.
Tam I, Schalock PC, González E, Yu J. Patch testing results from the Massachusetts General Hospital Contact Dermatitis Clinic, 2007–2016. Dermatitis. 2020;31(3):202–8. https://doi.org/10.1097/DER.0000000000000593.
Warshaw EM, Zug KA, Belsito DV, et al. Positive patch-test reactions to essential oils in consecutive patients From North America and Central Europe. Dermatitis. 2017;28(4):246–52. https://doi.org/10.1097/DER.0000000000000293.
DeKoven JG, Warshaw EM, Zug KA, et al. North American contact dermatitis group patch test results: 2015–2016. Dermatitis. 2018;29(6):297–309. https://doi.org/10.1097/DER.0000000000000417.
• Atwater AR, Ward JM, Liu B, et al. Fragrance- and botanical-related allergy and associated concomitant reactions: a retrospective analysis of the North American Contact Dermatitis Group Data 2007–2016. Dermatitis. 2021;32(1):42–52. https://doi.org/10.1097/DER.0000000000000661. A retrospective cross-sectional analysis of 5,504 patients with fragrance and botanical-related contact allergy. The study included concomitant reaction rates of ylang-ylang, lavender, peppermint and tea tree oils with each other in addition to fragrance mix I and II, balsam of Peru, Compositae mix, colophony and propolis.
Uter W, Gefeller O, Mahler V, Geier J. Trends and current spectrum of contact allergy in Central Europe: results of the Information Network of Departments of Dermatology (IVDK) 2007–2018. Br J Dermatol. 2020;183(5):857–65. https://doi.org/10.1111/bjd.18946.
Uter W, Bauer A, Belloni Fortina A, et al. Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015–2018. Contact Dermatitis. 2021;84(2):109–20. https://doi.org/10.1111/cod.13704.
• Zambello A, Caroppo F, Belloni Fortina A. Tea tree oil contact sensitization in children. Contact Dermatitis. 2021;84(2):139–140. https://doi.org/10.1111/cod.13699. First study to evaluate the prevalence of contact allergy to tea tree oil in pediatric patients. Of 695 children with suspected allergic contact dermatitis, 0.43% had a positive patch test reaction to tea tree oil.
Sabroe RA, Holden CR, Gawkrodger DJ. Contact allergy to essential oils cannot always be predicted from allergy to fragrance markers in the baseline series. Contact Dermatitis. 2016;74(4):236–41. https://doi.org/10.1111/cod.12528.
Gilissen L, Huygens S, Goossens A. Allergic contact dermatitis caused by topical herbal remedies: importance of patch testing with the patients’ own products. Contact Dermatitis. 2018;78(3):177–84. https://doi.org/10.1111/cod.12939.
Nath NS, Liu B, Green C, Atwater AR. Contact allergy to hydroperoxides of linalool and D-limonene in a US population. Dermatitis. 2017;28(5):313–6. https://doi.org/10.1097/DER.0000000000000318.
Erfurt-Berge C, Geier J, Mahler V. The current spectrum of contact sensitization in patients with chronic leg ulcers or stasis dermatitis - new data from the Information Network of Departments of Dermatology (IVDK). Contact Dermatitis. 2017;77(3):151–8. https://doi.org/10.1111/cod.12763.
Silvestre JF, Mercader P, González-Pérez R, et al. Sensitization to fragrances in Spain: a 5-year multicentre study (2011–2015). Contact Dermatitis. 2019;80(2):94–100. https://doi.org/10.1111/cod.13152.
Bingham LJ, Tam MM, Palmer AM, Cahill JL, Nixon RL. Contact allergy and allergic contact dermatitis caused by lavender: a retrospective study from an Australian clinic. Contact Dermatitis. 2019;81(1):37–42. https://doi.org/10.1111/cod.13247.
Morin CB, Sasseville D. Expanding patch testing beyond the baseline series: usefulness of customized antimicrobials, vehicles, and cosmetics series. Dermatitis. 2020;31(6):367–72. https://doi.org/10.1097/DER.0000000000000674.
Rolls S, Owen E, Bertram CG, et al. What is in? What is out? Updating the British Society for Cutaneous Allergy facial series. Br J Dermatol. 2021;184(1):151–5. https://doi.org/10.1111/bjd.19127.
Qin O, Cheng Y, Hu W, et al. Patch test in Chinese in Shanghai with cosmetic allergy to cosmetic series and products. J Cosmet Dermatol. 2020;19(8):2086–92. https://doi.org/10.1111/jocd.13249.
Chen B, Yu F, Chen W, et al. Contact sensitization to cosmetic series of allergens in female patients with rosacea: a prospective controlled study in China. J Cosmet Dermatol. 2020;00:1–8. https://doi.org/10.1111/jocd.13902.
Liang Y, Zhang X, Zhu J, Ali F, Mo H. Analysis of patch testing in patients with hand eczema at Shenzhen from 2016 to 2019. Postȩpy dermatologii i alergologii. 2021;38(1):170–2. https://doi.org/10.5114/ada.2021.104294.
Uter W, Schmidt E, Geier J, et al. Contact allergy to essential oils: current patch test results (2000–2008) from the Information Network of Departments of Dermatology (IVDK). Contact Dermatitis. 2010;63(5):277–83. https://doi.org/10.1111/j.1600-0536.2010.01768.x.
Dooms-Goossens A (1995) Patch testing without a kit. In: Reviews and Notes: Practical Contact Dermatitis: a Handbook for the Practitioner. Ann Intern Med. 1995;123(7):559. https://doi.org/10.7326/0003-4819-123-7-199510010-00048.
doTERRA. Part 7: Sensitivity Reactions-Determining Your Own Sensitivity: dōTERRA Essential Oils. Available at: https://www.doterra.com/US/en/essential-oil-safety-and-application-sensitivity-reactions-assess-sensitivity). Accessed on 1 Mar 2021.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Human and Animal Rights
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article is part of the Topical Collection on Contact Dermatitis
Rights and permissions
About this article
Cite this article
Buonomo, M., Warshaw, E. Contact Dermatitis to Essential Oils. Curr Derm Rep 10, 148–172 (2021). https://doi.org/10.1007/s13671-021-00337-2
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13671-021-00337-2