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How Wounding via Lasers Has Potential Photocarcinogenic Preventative Effects via Dermal Remodeling

  • Laser Therapy (J Jagdeo, Section Editor)
  • Published:
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Abstract

As the incidence of non-melanoma skin cancer (NMSC) is increasing, there is a growing need to identify effective preventive strategies. A recently proposed hypothesis states that NMSC photocarcinogenesis is tightly linked to insufficient insulin growth factor-1 expression by agglomerated senescent fibroblasts in geriatric dermis. This paucity of IGF-1 expression in senile skin allows basal keratinocytes to mitotically propagate their UVB-altered genome and potentially initiate an actinic neoplasm. Here, we review the role of the dermal microenvironment in NMSC pathogenesis, describe the impact of fibroblast senescence on this process, and discuss how laser-induced dermal wounding can be effectively used to prevent NMSC development in geriatric patients.

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References

  1. American Cancer Society, I. (2016) The key statistics about basal and squamous cell skin cancers? http://www.cancer.org/cancer/skincancer-basalandsquamouscell/detailedguide/skin-cancer-basal-and-squamous-cell-key-statistics

  2. Karia PS, Han J, Schmults CD. Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. J Am Acad Dermatol. 2013;68:957–66.

    Article  PubMed  Google Scholar 

  3. Jagdeo JR, Brody NI, Spandau DF, Travers JB. Important implications and new uses of ablative lasers in dermatology: fractional carbon dioxide laser prevention of skin cancer. Dermatol Surg. 2015;41:387–9.

    Article  CAS  PubMed  Google Scholar 

  4. Ikehata H, Ono T. The mechanisms of UV mutagenesis. J Radiat Res. 2011;52:115–25.

    Article  CAS  PubMed  Google Scholar 

  5. Wikonkal, N. M., and Brash, D. E. (1999) Ultraviolet radiation induced signature mutations in photocarcinogenesis. The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 4, 6–10

  6. Lewis DA, Travers JB, Spandau DF. A new paradigm for the role of aging in the development of skin cancer. J Invest Dermatol. 2009;129:787–91.

    Article  CAS  PubMed  Google Scholar 

  7. Lewis DA, Travers JB, Spandau DF. Aging-associated nonmelanoma skin cancer: a role for the dermis. In: Farage MA, Miller KW, Maibach HI, editors. Textbook of Aging Skin. 2009. p. 588–99.

    Google Scholar 

  8. Lewis DA, Travers JB, Somani A-K, Spandau DF. The IGF-1/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer. Oncogene. 2010;29:1475–85.

    Article  CAS  PubMed  Google Scholar 

  9. Kuhn C, Hurwitz SA, Kumar MG, Cotton J, Spandau DF. Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation. Int J Cancer. 1999;80(3):431–8.

    Article  CAS  PubMed  Google Scholar 

  10. Lewis DA, Yi Q, Travers JB, Spandau DF. UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53. Mol Biol Cell. 2008;19:1346–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Lewis DA, Travers JB, Machado C, Somani AK, Spandau DF. Reversing the aging stromal phenotype prevents carcinoma initiation. Aging. 2011;3:407–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Spandau DF, Lewis DA, Somani AK, Travers JB. Fractionated laser resurfacing corrects the inappropriate UVB response in geriatric skin. J Invest Dermatol. 2012;132:1591–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Tufaro AP, Chuang JC, Prasad N, Chuang A, Chuang TC, Fischer AC. Molecular markers in cutaneous squamous cell carcinoma. Int J Surg Oncol. 2011;2011:231475. doi:10.1155/2011/231475.

  14. Nikolaou V, Stratigos AJ, Tsao H. Hereditary nonmelanoma skin cancer. Semin Cutan Med Surg. 2012;31:204–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Brash DE, H. T., Nghiem P. Carcinogenesis: ultraviolet radiation. In: Wolff, editor. Fitzpatrick’s Dermatology in General Medicine 2003.

  16. Kraemer KH. Sunlight and skin cancer: another link revealed. Proc Natl Acad Sci U S A. 1997;94:11–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Barysch MJ, Hofbauer GF, Dummer R. Vitamin D, ultraviolet exposure, and skin cancer in the elderly. Gerontology. 2010;56:410–3.

    Article  PubMed  Google Scholar 

  18. Godar DE, Urbach F, Gasparro FP, van der Leun JC. UV doses of young adults. Photochem Photobiol. 2003;77:453–7.

    Article  CAS  PubMed  Google Scholar 

  19. Whiteman DC, Whiteman CA, Green AC. Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies. Cancer Causes Control. 2001;12:69–82.

    Article  CAS  PubMed  Google Scholar 

  20. Travers JB, Spandau DF, Lewis DA, Machado C, Kingsley M, Mousdicas N, et al. Fibroblast senescence and squamous cell carcinoma: how wounding therapies could be protective. Dermatol Surg. 2013;39:967–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Westerdahl J, Olsson H, Ingvar C. At what age do sunburn episodes play a crucial role for the development of malignant melanoma. Euro J Cancer (Oxford, England: 1990). 1994;30a:1647–54.

    Article  CAS  Google Scholar 

  22. Zouboulis CC, Makrantonaki E. Clinical aspects and molecular diagnostics of skin aging. Clin Dermatol. 2011;29:3–14.

    Article  PubMed  Google Scholar 

  23. Nakanishi M, Niida H, Murakami H, Shimada M. DNA damage responses in skin biology—implications in tumor prevention and aging acceleration. J Dermatol Sci. 2009;56:76–81.

    Article  CAS  PubMed  Google Scholar 

  24. Moriwaki S, Takahashi Y. Photoaging and DNA repair. J Dermatol Sci. 2008;50:169–76.

    Article  CAS  PubMed  Google Scholar 

  25. Thompson SC, Jolley D, Marks R. Reduction of solar keratoses by regular sunscreen use. N Engl J Med. 1993;329:1147–51.

    Article  CAS  PubMed  Google Scholar 

  26. Naylor MF, Boyd A, Smith DW, Cameron GS, Hubbard D, Neldner KH. High sun protection factor sunscreens in the suppression of actinic neoplasia. Arch Dermatol. 1995;131:170–5.

    Article  CAS  PubMed  Google Scholar 

  27. Ulrich C, Jurgensen JS, Degen A, Hackethal M, Ulrich M, Patel MJ, et al. Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study. Br J Dermatol. 2009;161 Suppl 3:78–84.

    Article  PubMed  Google Scholar 

  28. Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF, Kripke ML, et al. Carcinogenesis: ultraviolet radiation. New York: McGraw-Hill; 1993.

    Google Scholar 

  29. D’Errico M, Teson M, Calcagnile A, De Santis LP, Nikaido O, Botta E, et al. Apoptosis and efficient repair of DNA damage protect human keratinocytes against UVB. Cell Death Differ. 2003;10:754–6.

    Article  PubMed  Google Scholar 

  30. Tavakkol A, Elder JT, Griffiths CE, Cooper KD, Talwar H, Fisher GJ, et al. Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin. J Invest Dermatol. 1992;99:343–9.

    Article  CAS  PubMed  Google Scholar 

  31. Malvehy J. A new vision of actinic keratosis beyond visible clinical lesions. J Eur Acad Dermatol Venereol. 2015;29 Suppl 1:3–8.

    Article  PubMed  Google Scholar 

  32. Schmitt AR, Bordeaux JS. Solar keratoses: photodynamic therapy, cryotherapy, 5-fluorouracil, imiquimod, diclofenac, or what? Facts and controversies. Clin Dermatol. 2013;31:712–7.

    Article  PubMed  Google Scholar 

  33. Gupta AK, Paquet M, Villanueva E, Brintnell W. Interventions for actinic keratoses. Cochrane Database Syst Rev. 2012;12:Cd004415.

    PubMed  Google Scholar 

  34. de Berker D, McGregor JM, Hughes BR. Guidelines for the management of actinic keratoses. Br J Dermatol. 2007;156:222–30.

    Article  PubMed  Google Scholar 

  35. Coleman 3rd WP, Yarborough JM, Mandy SH. Dermabrasion for prophylaxis and treatment of actinic keratoses. Dermatol Surg. 1996;22:17–21.

    PubMed  Google Scholar 

  36. El-Domyati MM, Attia SK, Esmat AM, Ahmad HM, Abdel Wahab HM, Badr BM. Effect of laser resurfacing on p53 expression in photoaged facial skin. Dermatol Surg. 2007;33:668–75.

    CAS  PubMed  Google Scholar 

  37. Kessels JP, Nelemans PJ, Mosterd K, Kelleners-Smeets NW, Krekels GA, Ostertag JU. Laser-mediated photodynamic therapy: an alternative treatment for actinic keratosis? Acta Derm Venereol. 2016;96:351–4.

  38. Song HS, Jung SE, Jang YH, Kang HY, Lee ES, Kim YC. Fractional carbon dioxide laser-assisted photodynamic therapy for patients with actinic keratosis. Photodermatol Photoimmunol Photomed. 2015;31:296–301.

    Article  CAS  PubMed  Google Scholar 

  39. Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, et al. The hallmarks of fibroblast ageing. Mech Ageing Dev. 2014;138:26–44.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This research is supported by grants from the National Institutes of Environmental Health Sciences (ES020866, DFS, JBT), the National Institute on Aging (AG048946, DFS, JBT), and the Veterans Administration (1101CX000809, JBT). AK was supported by a fellowship from the National Institute of Arthritis Musculoskeletal and Skin Diseases (T32AR062495).

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Authors and Affiliations

  1. Department of Dermatology, Indiana University School of Medicine, 975 West Walnut Street, Rm 349, Indianapolis, IN, 46202, USA

    Aleksandar Krbanjevic, Jeffrey B. Travers & Dan F Spandau

  2. Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, Health Sciences Bldg 207, Dayton, OH, 45435-0001, USA

    Jeffrey B. Travers

  3. Dayton Veteran Affairs Medical Center, 3640 Colonel Glenn Highway, Health Sciences Bldg 207, Dayton, OH, 45435-0001, USA

    Jeffrey B. Travers

  4. Biochemistry & Molecular Biology, Indiana University School of Medicine, 975 West Walnut Street, Rm 349, Indianapolis, IN, 46202, USA

    Dan F Spandau

Authors
  1. Aleksandar Krbanjevic
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  2. Jeffrey B. Travers
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  3. Dan F Spandau
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Corresponding author

Correspondence to Dan F Spandau.

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Conflict of Interest

Dr. Aleksandar Krbanjevic, Dr. Jeffrey B. Travers, and Dr. Dan F Spandau declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Laser Therapy

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Krbanjevic, A., Travers, J.B. & Spandau, D.F. How Wounding via Lasers Has Potential Photocarcinogenic Preventative Effects via Dermal Remodeling. Curr Derm Rep 5, 222–227 (2016). https://doi.org/10.1007/s13671-016-0143-8

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  • DOI: https://doi.org/10.1007/s13671-016-0143-8

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