Japan Pharmacogenomics Data Science Consortium Database and Its Application for Drug Safety Analyses
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Severe adverse drug reactions (ADRs) are significantly influenced by the genetic background of an individual, and pharmacogenomics (PGx) is strongly expected to reveal the cause of severe ADRs. Genome-wide association studies (GWASs) for severe ADRs have been conducted worldwide, and a genomic database of representative samples of the ethnic population can be used as controls for GWAS for severe ADRs. Six Japanese pharmaceutical companies, Astellas, Daiichi Sankyo, Mitsubishi Tanabe, Otsuka, Taisho, and Takeda, therefore established the Japan Pharmacogenomics Data Science Consortium (JPDSC) and built a Japanese genomic database in 2009. This database promotes the application of PGx in drug development by each member company and PGx researches for expanding Japanese drug safety information at the genomic level.
KeywordPharmacogenomics GWAS Drug safety
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Conflict of Interest
Koji Suematsu declares that they have no conflict of interest.
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This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
- 6.•Kamitsuji S, Matsuda T, Nishimura K, et al. Japan PGx Data Science Consortium Database: SNPs and HLA genotype data from 2994 Japanese healthy individuals for pharmacogenomics studies. J Hum Genet. 2015;60:319–26. The study evaluates the database in the various aspects of genetics and shows it will be useful as control data for conducting PGx studies.CrossRefPubMedGoogle Scholar
- 7.••Tohkin M, Kaniwa N, Saito Y, et al. A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Pharmacogenomics J. 2013;13:60–9. The study revealed that the SNPs on chromosome 6 including rs9263726 in PSORS1C1 in absolute linkage disequilibrium with HLA-B*5801 are in strong association with allopurinol-induced SJS/TEN in Japanese.Google Scholar
- 8.••Kaniwa N, Sugiyama E, Saito Y, et al. Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects. Pharmacogenomics. 2013;14:1821–31. The study suggests that HLA-A*02:07 and HLA-B*51:01 are potential biomarkers respectively for zonisamide- and phenobarbital-induced SJS/TEN in Japanese.Google Scholar
- 9.••Chung WH, Chang WC, Lee YS, et al. Genetic variants associated with phenytoin-related severe cutaneous adverse reactions. JAMA. 2014;312:525–34. The study identified CYP2C9*3 known to reduce drug clearance as an important genetic factor associated with phenytoin-induced severe cutaneous adverse reactions.Google Scholar
- 10.••Maekawa K, Nakamura R, Kaniwa N, et al. Development of a simple genotyping method for the HLA-A*31:01-tagging SNP in Japanese. Pharmacogenomics. 2015;16:1689–99. The study revealed that the three SNPs, rs1150738, rs3869066 and rs259945, are the useful biomarkers in absolute linkage disequilibrium with HLA-A*31:01 , a risk factor for carbamazepine related SJS/TEN in Japanese.Google Scholar