Japan Pharmacogenomics Data Science Consortium Database and Its Application for Drug Safety Analyses
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Severe adverse drug reactions (ADRs) are significantly influenced by the genetic background of an individual, and pharmacogenomics (PGx) is strongly expected to reveal the cause of severe ADRs. Genome-wide association studies (GWASs) for severe ADRs have been conducted worldwide, and a genomic database of representative samples of the ethnic population can be used as controls for GWAS for severe ADRs. Six Japanese pharmaceutical companies, Astellas, Daiichi Sankyo, Mitsubishi Tanabe, Otsuka, Taisho, and Takeda, therefore established the Japan Pharmacogenomics Data Science Consortium (JPDSC) and built a Japanese genomic database in 2009. This database promotes the application of PGx in drug development by each member company and PGx researches for expanding Japanese drug safety information at the genomic level.
KeywordPharmacogenomics GWAS Drug safety
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Conflict of Interest
Koji Suematsu declares that they have no conflict of interest.
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This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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