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Current Dermatology Reports

, Volume 4, Issue 4, pp 168–178 | Cite as

Staging and Management of High-Risk Cutaneous Squamous Cell Carcinoma

  • Pritesh S. Karia
  • Emily Stamell Ruiz
  • Chrysalyne D. SchmultsEmail author
Skin Cancer (JA Carucci, Section Editor)
  • 113 Downloads
Part of the following topical collections:
  1. Topical Collection on Skin Cancer

Abstract

Cutaneous squamous cell carcinoma (CSCC) is among the most common malignancies in the USA and among Caucasians. Most patients with CSCC have an excellent prognosis. However, there is a high-risk subset that carries an elevated risk of local recurrence, nodal metastasis, and death. Treatment modalities for local disease are highly effective and even early nodal disease is highly curable; however, once uncontrollable loco-regional disease or distant metastasis develops, survival is significantly diminished. Current tumor staging systems for CSCC have limitations and clinicians have little evidence to guide decisions regarding nodal staging and adjuvant therapy. The aim of this review is to highlight the identification and management of high-risk CSCCs, discuss the pitfalls of current staging systems, and introduce novel alternative staging systems for CSCC that have been proposed in recent years.

Keywords

High-risk cutaneous squamous cell carcinoma Nodal metastasis AJCC staging Radiation Chemotherapy Skin cancer 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Pritesh S. Karia, Emily Stamell Ruiz, and Chrysalyne D. Schmults declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Pritesh S. Karia
    • 1
  • Emily Stamell Ruiz
    • 1
  • Chrysalyne D. Schmults
    • 1
    Email author
  1. 1.Department of Dermatology, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA

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