Nanotechnology may potentially revolutionize the foundation of disease treatment and prevention at cellular and molecular levels. Unlike conventional therapies, which often suffer from lack of specificity and dose-related side effects, nanomedicine will bring nano-sized particulate systems to enhance bioavailability of therapeutics as well as their delivery in a site-specific manner, thus, resulting in increased therapeutic index while limiting toxicity. Nanoparticles, constructed from a wide range of biomaterials, can be exploited to efficiently deliver biotherapeutics into the skin in order to improve dermatological treatments. This review provides a perspective on nanoscale delivery systems designed for topical delivery of small drugs, peptides/proteins, and nucleic acids.
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The research in this paper was supported by grants from the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council of Canada, the Canada Foundation for Innovation, and the Ontario Research Fund. The generous support of the Canada Research Chairs Program is also gratefully acknowledged (M. Foldvari).
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Conflict of Interest
M Foldvari has received consulting fees from Helix BioPharma Corporation and has a patent lipid vesicle compositions pending, and a patent Multicompartmental lipid vesicle compositions pending.
A Rafiee declares no conflicts of interest.
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This article does not contain any studies with human or animal subjects performed by any of the authors.
This article is part of the Topical Collection on Immunology
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Foldvari, M., Rafiee, A. Perspectives on Using Nanoscale Delivery Systems in Dermatological Treatment. Curr Derm Rep 4, 1–7 (2015). https://doi.org/10.1007/s13671-014-0092-z
- Topical delivery
- Protein delivery
- Nucleic acid delivery