Abstract
In older adults with aortic stenosis, we evaluated whether accelerometer-measured physical activity provides distinct clinical information apart from self-reported surveys or performance-based function tests. We employed wrist-mounted accelerometry in 52 subjects with severe aortic stenosis prior to transcatheter aortic valve replacement (TAVR). Daily daytime activity was estimated using the maximum 10 h of daily accelerometer-measured activity (M10) reported in activity counts. Subjects completed baseline surveys (New York Heart Association (NYHA), Short Form 12 (SF12), Kansas City Cardiomyopathy Questionnaire (KCCQ), EuroQol-5D (EQ-5D), Revised Life Orientation Test (LOT-R), Life Space, Detailed Activity Form) and performance-based function tests (Short Physical Performance Battery, 6-min walk test distance, grip strength) to estimate functional status. Simple and multiple linear regression models were used to evaluate the relationship between accelerometer-measured activity and survey data and performance-based function tests. Among all baseline surveys and performance-based function tests, the only statistically significant univariable relationships identified were weak, negative associations between M10 and SF-12 Mental Composite Score (R 2 = 0.1970, P = 0.04) and between M10 and grip strength (R 2 = 0.1568, P = 0.004). Neither multiple linear regression of overall survey data (R 2 = 0.6159, P = 0.23) nor performance-based function tests (R 2 = 0.1743, P = 0.10) correlated with M10. Self-reported surveys and performance-based function tests are not meaningfully correlated with daytime accelerometer-measured activity. The results of our study suggest that accelerometer-measured physical activity provides distinct clinical information apart from self-reported surveys or performance-based function tests.
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Acknowledgments
Dr. Green is supported by Career Development Grant Awards K23 HL12114 from the National Heart, Lung, and Blood Institute. Dr. Maurer is supported by a Mid-Career Mentoring Award from the NIA K24AG036778. Ms. Lazarte is supported by a grant from the NIA.
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Yufei Tang declares that he has no conflict of interest.
Philip Green declares that he has no conflict of interest.
Mathew Maurer declares that he has no conflict of interest.
Rosa Lazarte declares that she has no conflict of interest.
Jonathan Rubin Kuzniecky declares that he has no conflict of interest.
Ming Yang Hung declares that he has no conflict of interest.
Melissa Garcia declares that she has no conflict of interest.
Susheel Kodali is the national P.I. for the Sapien 3 trial utilizing the Edwards Sapien 3 valve. This trial was funded by Edwards Lifesciences, and Columbia University received funding for the research. Dr. Kodali has also received compensation from Edwards Lifesciences for service as a consultant, but has not received any financial compensation in the past 12 months as of the submission of this article, and has also served as an unpaid consultant for Medtronic.
Tamara Harris declares that she has no conflict of interest.
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This article is part of the Topical Collection on Cardiovascular Disease in the Elderly
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Tang, Y., Green, P., Maurer, M. et al. Relationship Between Accelerometer-Measured Activity and Self-Reported or Performance-Based Function in Older Adults with Severe Aortic Stenosis. Curr Geri Rep 4, 377–384 (2015). https://doi.org/10.1007/s13670-015-0152-7
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DOI: https://doi.org/10.1007/s13670-015-0152-7