Abstract
Gestational diabetes mellitus (GDM) is a pancreatic function insufficiency to overcome the insulin resistance associated with the pregnant state. The prevalence of GDM is about 2–5 % of normal pregnancies. To prevent the adverse outcome for the mother, the fetus, and neonatal period, detection of GDM is important. Screening methods vary by clinics. Screening can either be selective, based upon risk stratification or universal. Timely testing enables the obstetrician to assess glucose tolerance in the presence of the insulin-resistant state of pregnancy and permits treatment to begin before excessive fetal growth has occurred. After the diagnosis of GDM, close perinatal surveillance is necessary. The goal of treatment in GDM is to reduce fetal and maternal morbidity and mortality. The exact glucose values needed are still unknown. The decision whether and when to induce delivery depends on gestational age, fetal growth, maternal glucose levels, and Bishop score. Screening, follow-up, and treatment of GDM still have controversies.
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Dodd JM, Crowther CA, Antoniou G, et al. Screening for gestational diabetes: the effect of varying blood glucose definitions in the prediction of adverse maternal and infant health outcomes. Aust N Z J Obstet Gynaecol. 2007;47:307.
Hillier TA, Pedula KL, Schmidt MM, et al. Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia. Diabetes Care. 2007;30:2287.
Committee on Practice Bulletins—Obstetrics. Practice Bulletin No. 137. Gestational diabetes mellitus. Obstet Gynecol. 2013;122:406.
International Association of Diabetes and Pregnancy Study Groups Consensus Panel, Metzger BE, Gabbe SG, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33:676. This article defines main characteristics of gestational diabetes.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37 Suppl 1:S81. This article defines main characteristics of gestational diabetes.
Thompson D, Berger H, Feig D, et al. Diabetes and pregnancy. Can J Diabetes. 2013;37:S1.
Cosson E, Benbara A, Pharisien I, et al. Diagnostic and prognostic preformances over 9 years of a selective screening strategy for gestational diabetes mellitus in a cohort of 18,775 subjects. Diab Care. 2013;36:598–603.
Danilenko-Dixon DR, Van Winter JT, Nelson RL, Ogburn Jr PL. Universal versus selective gestational diabetes screening: application of 1997 American Diabetes Association recommendations. Am J Obstet Gynecol. 1999;181:798.
HAPO Study Cooperative Research Group, Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358:1991–2002. This article defines main characteristics of gestational diabetes.
International Association of Diabetes and Pregnancy Study Groups Consensus, Metzger BE, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33:676–82. This article defines main characteristics of gestational diabetes.
National Institutes of Health Consensus Development Conference: Diagnosing Gestational Diabetes Mellitus Conference, March 4–6, Obstet Gynecol. 2013;122(2 Pt 1):358-69.
Farrar D, Duley L, Medley N, Lawlor DA. Different strategies for diagnosing gestational diabetes to improve maternal and infant health. Cochrane Database Syst Rev. 2015;21(1):CD007122.
Hay WW. Placental-fetal glucose exchange and fetal glucose metabolism. Trans Am Clin Climatol Assoc. 2006;117:321–40.
Galan HL, Battaglia FC. The biology of abnormal fetal growth anddevelopment. In: Reece EA, Coustan DR, Gabbe SG, editors. Diabetes in women. Philadelphia: Lippincott Williams & Wilkins; 2004. p. 159–67.
Kwik M, Seeho SK, Smith C, McElduff A, Morris JM. Outcomes of pregnancies affected by impaired glucose tolerance. Diabetes Res Clin Pract. 2007;77(2):263.
Crowther CA, Hiller JE, Moss JR, McPhee AJ, Jeffries WS, Robinson JS. Australian Carbohydrate Intolerance Study in Pregnant Women (ACHOIS) trial group. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med. 2005;352(24):2477.
American College of Obstetricians and Gynecologists: fetal macrosomia. Practice Bulletin No. 22, November 2000.
Black MH, Sacks DA, Xiang AH, Lawrence JM. The relative contribution of prepregnancy overweight and obesity, gestational weight gain, and IADPSG-defined gestational diabetes mellitus to fetal overgrowth. Diabetes Care. 2013;36(1):56.
Coustan DR. Gestational diabetes mellitus. Clin Chem. 2013;59(9):1310–21.
Stotland NE, Caughey AB, Breed EM, Escobar GJ. Risk factors and obstetric complications associated with macrosomia. Int J Gynaecol Obstet. 2004;87(3):220.
Lai FY, Johnson JA, Dover D, Kaul P. Outcomes of singleton and twin pregnancies complicated by preexisting diabetes and gestational diabetes: a population-based study in Alberta, Canada, 2005-2011. J Diabetes. 2014;15:357–68.
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cooperative Research Group. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: preeclampsia. Am J Obstet Gynecol. 2010;202(3):255. e1.
Carpenter MW. Gestational diabetes, pregnancy hypertension, and late vascular disease. Diabetes Care. 2007;30 Suppl 2:S246.
Yogev Y, Xenakis EM, Langer O. The association between preeclampsia and the severity of gestational diabetes: the impact of glycemic control. Am J Obstet Gynecol. 2004;191(5):1655.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Maternal insulin resistance and preeclampsia. Am J Obstet Gynecol. 2011;204(4):327–e1.
Sierra-Laguado J, García RG, Celedón J, Arenas-Mantilla M, Pradilla LP, Camacho PA, et al. Determination of insulin resistance using the homeostatic model assessment (HOMA) and its relation with the risk of developing pregnancy-induced hypertension. Am J Hypertens. 2007;20(4):437.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med. 2009;361(14):1339–48.
Hamza A, Herr D, Solomayer EF, Meyberg-Solomayer G. Polyhydramnios: causes diagnosis and therapy. Geburtshilfe Frauenheilkd. 2013;73(12):1241–6.
Vink JY, Poggi SH, Ghidini A, et al. Amniotic fluid index and birth weight: is there a relationship in diabetics with poor glycemic control? Am J Obstet Gynecol. 2006;195:848.
Dudley DJ. Diabetic-associated stillbirth: incidence, pathophysiology, and prevention. Obstet Gynecol Clin North Am. 2007;34(2):293.
Starikov R, Dudley D, Reddy UM. Stillbirth in the pregnancy complicated by diabetes. Curr Diab Rep. 2015;15(3):580.
Hawdon JM. Babies born after diabetes in pregnancy: what are the short- and long-term risks and how can we minimise them? Best Pract Res Clin Obstet Gynaecol. 2011;25(1):91–104.
Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005;115(3):e290.
Malcolm JC, Lawson ML, Gaboury I, Lough G, Keely E. Glucose tolerance of offspring of mother with gestational diabetes mellitus in a low-risk population. Diabet Med. 2006;23(5):565.
Hawdon JM. The infant of a diabetic mother. In: Rennie J, editor. Textbook of neonatology. 4th ed. Edinburgh: Churchill Livingstone; 2005.
Hawdon JM. Hypoglycaemia and brain injury—when neonatal metabolic adaptation fails. In Levene M & Chervenak A (eds.) Fetal and neonatal neurology and neurosurgery. Elsevier, 2009.
Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Donovan L. Benefits and harms of treating gestational diabetes mellitus: a systematic review and meta-analysis for the U.S. Preventive Services Task Force and the National Institutes of Health Office of Medical Applications of Research. Ann Intern Med. 2013;159(2):123.
American Diabetes Association: nutritional management during pregnancy in preexisting diabetes. In Medical Management of Pregnancy Complicated by Diabetes, 3rd ed. Alexandria, VA, American Diabetes Association, 2000, p 70. This article defines main characteristics of gestational diabetes.
Horie I, Kawasaki E, Sakanaka A, Takashima M, Maeyama M, Ando T, et al. Efficacy of nutrition therapy for glucose intolerance in Japanese women diagnosed with gestational diabetes based on IADPSG criteria during early gestation. Diabetes Res Clin Pract. 2015;21:S0168–8227.
Viana LV, Gross JL, Azevedo MJ. Dietary intervention in patients with gestational diabetes mellitus: a systematic review and meta-analysis of randomized clinical trials on maternal and newborn outcomes. Diabetes Care. 2014;37(12):3345.
Cheng YW, Chung JH, Kurbisch-Block I, Inturrisi M, Shafer S, Caughey AB. Gestational weight gain and gestational diabetes mellitus: perinatal outcomes. Obstet Gynecol. 2008;112(5):1015.
Downs DS, Chasan-Taber L, Evenson KR, Leiferman J, Yeo S. Physical activity and pregnancy: past and present evidence and future recommendations. Res Q Exerc Sport. 2012;83(4):485–502.
Cordero Y, Mottola MF, Vargas J, Blanco M, Barakat R. Exercise is associated with a reduction in gestational diabetes mellitus. Med Sci Sports Exerc. 2014 Oct 20. [Epub ahead of print]
Mottola MF, Ruchat SM. Exercise guidelines for women with gestational diabetes. In: Radenkovic M, (Ed.). Gestational Diabetes. Croatia: InTech; 2011. P. 339-362.
Barakat R, Pelaez M, Lopez C, Lucia A, Ruiz JR. Exercise during pregnancy and gestational diabetes-related adverse effects: a randomised controlled trial. Br J Sports Med. 2013;47(10):630.
Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. American College of Sports Medicine, American Diabetes Association. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care. 2010;33(12):e147–67.
American Diabetes Association. Position statement on gestational diabetes. Diabetes Care. 2004;27:S88–90.
Buchanan TA, Kjos SL. Counterpoint: glucose monitoring in gestational diabetes: lots of heat, not much light. Diabetes Care. 2003;26:948–9.
Hawkins JS, Casey BM, Lo JY, Moss K, McIntire DD, Leveno KJ. Weekly compared with daily blood glucose monitoring in women with diet-treated gestational diabetes. Obstet Gynecol. 2009;113(6):1307.
Metzger BE, Buchanan TA, Coustan DR, de Leiva A, Dunger DB, Hadden DR, et al. Summary and recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes Care. 2007;30 Suppl 2:S251.
Committee on Practice Bulletins—Obstetrics. Practice Bulletin No. 137. Gestational diabetes mellitus. Obstet Gynecol. 2013;122(2 Pt 1):406.
American Diabetes Association. Standards of medical care in diabetes—2014. Diabetes Care. 2014;37 Suppl 1:S14. This article defines main characteristics of gestational diabetes.
Kjos SL, Schaefer-Graf UM. Modified therapy for gestational diabetes using high-risk and low-risk fetal abdominal circumference growth to select strict versus relaxed maternal glycemic targets. Diabetes Care. 2007;30 Suppl 2:S200–5.
Ashwal E, Hod M. Gestational diabetes mellitus: where are we now? Clin Chim Acta. 2015 Feb 2. pii: S0009-8981(15)00043-1. This article defines main characteristics of gestational diabetes.
Buschur E, Brown F, Wyckoff J. Using oral agents to manage gestational diabetes: what have we learned? Curr Diab Rep. 2015;15(2):570.
de Valk HW, Visser GH. Insulin during pregnancy, labour and delivery. Best Pract Res Clin Obstet Gynaecol. 2011;25(1):65–76.
Nachum Z, Ben-Shlomo I, Weiner E, Shalev E. Twice daily versus four times daily insulin dose regimens for diabetes in pregnancy: randomised controlled trial. BMJ. 1999;319:1223–7.
Mukhopadhyay A, Farrell T, Fraser RB, Ola B. Continuous subcutaneous insulin infusion vs intensive conventional insulin therapy in pregnant diabetic women: a systematic review and metaanalysis of randomized, controlled trials. Am J Obstet Gynecol. 2007;197:447–56.
Nicholson WK, Wilson LM, Witkop CT, Baptiste-Roberts K, Bennett WL, Bolen S, et al. Therapeutic management, delivery, and postpartum risk assessment and screening in gestational diabetes. Evid Rep Technol Assess (Full Rep). 2008;162:1–96.
Price N, Bartlett C, Gillmer M. Use of insulin glargine during pregnancy: a case–control pilot study. BJOG. 2007;114:453–7.
Lain KY, Garabedian MJ, Daftary A, Jeyabalan A. Neonatal adiposity following maternal treatment of gestational diabetes with glyburide compared with insulin. Am J Obstet Gynecol. 2009;200(501):e501–6.
Rowan JA, Hague WM, Gao W, Battin MR, Moore MP. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med. 2008;358:2003–15.
Silva JC, Fachin DR, Coral ML, Bertini AM. Perinatal impact of the use of metformin and glyburide for the treatment of gestational diabetes mellitus. J Perinat Med. 2012;40:225–8.
Camelo Castillo W, Boggess K, Sturmer T, Brookhart MA, Benjamin Jr DK, Jonsson Funk M. Trends in glyburide compared with insulin use for gestational diabetes treatment in the United States, 2000–2011. Obstet Gynecol. 2014;123:1177–84. This article defines main characteristics of gestational diabetes.
Cassina M, Donà M, Di Gianantonio E, Litta P, Clementi M. First-trimester exposure to metformin and risk of birth defects: a systematic review and meta-analysis. Hum Reprod Update. 2014;20(5):656–69.
Gardosi J, Madurasinghe V, Williams M, Malik A, Francis A. Maternal and fetal risk factors for stillbirth: population based study. BMJ. 2013;346:f108.
Mitanchez D. Foetal and neonatal complications in gestational diabetes: perinatal mortality, congenital malformations, macrosomia, shoulder dystocia, birth injuries, neonatal complications. Diabetes Metab. 2010;36(6 Pt 2):617–27.
Rouse DJ, Owen J, Goldenberg RL, Cliver SP. The effectiveness and costs of elective cesarean delivery for fetal macrosomia diagnosed by ultrasound. JAMA. 1996;276(18):1480–6.
Gabbe SG, Mestman JG, Freeman RK, Anderson GV, Lowensohn RI. Management and outcome of class A diabetes mellitus. Am J Obstet Gynecol. 1977;127(5):465.
Niu B, Lee VR, Cheng YW, Frias AE, Nicholson JM, Caughey AB. What is the optimal gestational age for women with gestational diabetes type A1 to deliver? Am J Obstet Gynecol. 2014;211(4):418. e1-6.
Kjos SL, Henry OA, Montoro M, Buchanan TA, Mestman JH. Insulin-requiring diabetes in pregnancy: a randomized trial of active induction of labor and expectant management. Am J Obstet Gynecol. 1993;169(3):611.
Lurie S, Insler V, Hagay ZJ. Induction of labor at 38 to 39 weeks of gestation reduces the incidence of shoulder dystocia in gestational diabetic patients class A2. Am J Perinatol. 1996;13(5):293.
Rosenstein MG, Cheng YW, Snowden JM, Nicholson JM, Doss AE, Caughey AB. The risk of stillbirth and infant death stratified by gestational age in women with gestational diabetes. Am J Obstet Gynecol. 2012;206(4):309.
Yogev Y, Ben-Haroush A, Chen R, Glickman H, Kaplan B, Hod M. Active induction management of labor for diabetic pregnancies at term; mode of delivery and fetal outcome—a single center experience. Eur J Obstet Gynecol Reprod Biol. 2004;114(2):166–70.
Blumer I, Hadar E, Hadden DR, Jovanovič L, Mestman JH, Murad MH, et al. Diabetes and pregnancy: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2013;98(11):4227–49.
Tigas S, Sunehag A, Haymond MW. Metabolic adaptation to feeding and fasting during lactation in humans. J Clin Endocrinol Metab. 2002;87(1):302–7.
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Engin Korkmazer, Neşe Solak, and Vehbi Yavuz Tokgöz declare that they have no conflict of interest.
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This article is part of the Topical Collection on High-Risk Gestation and Prenatal Medicine
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Korkmazer, E., Solak, N. & Tokgöz, V.Y. Gestational Diabetes: Screening, Management, Timing of Delivery. Curr Obstet Gynecol Rep 4, 132–138 (2015). https://doi.org/10.1007/s13669-015-0113-3
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DOI: https://doi.org/10.1007/s13669-015-0113-3