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Ketogenic Diet for Malignant Gliomas: a Review

Current Nutrition Reports volume 9, pages 258–263 (2020)Cite this article

Abstract

Purpose of Review

In this review, we examine the postulated mechanisms of therapeutic effect of ketogenic diets in the treatment of gliomas, review the completed clinical trials, and discuss further directions in this field.

Recent Findings

Cancers including gliomas are characterized by derangements in cellular metabolism. In vitro and animal studies have revealed that dietary interventions to reduce glucose and glycolytic pathways in gliomas may have a therapeutic effect. Early trials in patients with malignant gliomas have shown feasibility, but are not robust enough yet to demonstrate clinical applicability.

Summary

Therapies for malignant gliomas of the brain are increasingly using a multi-targeted approach. The use of ketogenic diets and its variants may offer a unique and promising anti-glioma treatment by exploiting metabolic alterations seen in cancers including gliomas seen at the cellular level, which may work in concert with other therapies.

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Authors and Affiliations

  1. Department of Neurosurgery, Global Neurosciences Institute, 3100 Princeton Pike Ste D, Lawrenceville, NJ, 08648, USA

    Jonathan G. Thomas & Erol Veznedaroglu

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  1. Jonathan G. Thomas
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  2. Erol Veznedaroglu
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Correspondence to Jonathan G. Thomas.

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Thomas, J.G., Veznedaroglu, E. Ketogenic Diet for Malignant Gliomas: a Review. Curr Nutr Rep 9, 258–263 (2020). https://doi.org/10.1007/s13668-020-00332-2

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  • DOI: https://doi.org/10.1007/s13668-020-00332-2

Keywords

  • Glioma
  • Glioblastoma
  • Gbm
  • Astrocytoma
  • Ketogenic diet
  • Dietary intervention