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Ketogenic Diet: an Endocrinologist Perspective

Current Nutrition Reports volume 8, pages 402–410 (2019)Cite this article

Abstract

Purpose of Review

Obesity and its related comorbidities make up a large part of healthcare expenditures. Despite a wide array of options for treatment of obesity, rates of sustained weight loss continue to be low, leading patients to seek alternative treatment options. Although the first medically utilized ketogenic diet was described nearly 100 years ago, it has made a resurgence as a treatment option for obesity. Despite increased popularity in the lay public and increased use of ketogenic dietary strategies for metabolic therapy, we are still beginning to unravel the metabolic impact of long-term dietary ketosis.

Recent Findings

There are a number of recent trials that have highlighted the short- and long-term benefits of ketogenic diet on weight, glycemic control, and other endocrine functions including reproductive hormones.

Summary

This review is a summary of available data on the effectiveness and durability of the ketogenic diet when compared to conventional interventions. Ketogenic dietary strategies may play a role in short-term improvement of important metabolic parameters with potential for long-term benefit. However, response may vary due to inter-individual ability to maintain long-term carbohydrate restriction.

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Authors and Affiliations

  1. Department of Family Medicine, Mayo Clinic, Rochester, MN, USA

    Aravind Reddy Kuchkuntla & Tamim Rajjo

  2. Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA

    Meera Shah, Saketh Velapati, Ryan T. Hurt & Manpreet S. Mundi

  3. Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

    Victoria M. Gershuni

  4. Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA

    Sanjeev Nanda & Ryan T. Hurt

  5. Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA

    Ryan T. Hurt

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  1. Aravind Reddy Kuchkuntla
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  2. Meera Shah
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Contributions

Manpreet Mundi and Ryan Hurt formulated an outline of the manuscript. Aravind Kuchkuntla created the first draft. Manpreet Mundi, Meera Shah, Aravind Kuchkuntla, Saketh Velapati, Victoria Gershuni, Tamim Rajjo, Sanjeev Nanda, and Ryan Hurt critically revised the manuscript. All authors agree to be responsible for its content.

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Correspondence to Manpreet S. Mundi.

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Conflict of Interest

Aravind Reddy Kuchkuntla declares that he has no conflict of interest.

Meera Shah declares that she has no conflict of interest.

Saketh Velapati declares that he has no conflict of interest.

Victoria M. Gershuni declares that she has no conflict of interest.

Tamim Rajjo declares that he has no conflict of interest.

Sanjeev Nanda declares that he has no conflict of interest.

Ryan T. Hurt has served as a consultant for Nestlé.

Manpreet S. Mundi has received research funding from Fresenius Kabi, Nestlé, and Real Food Blends.

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Kuchkuntla, A.R., Shah, M., Velapati, S. et al. Ketogenic Diet: an Endocrinologist Perspective. Curr Nutr Rep 8, 402–410 (2019). https://doi.org/10.1007/s13668-019-00297-x

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Keywords

  • Obesity
  • Diabetes
  • Ketogenic diet
  • Weight loss